5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE
- Product Name
- 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE
- CAS No.
- 18672-03-2
- Chemical Name
- 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE
- Synonyms
- 5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-AMINE;2-Amino-5,6-dichlorobenzimidazole;5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE;2-Amino-5,6-dichloro-1H-benzimidazole;1H-Benzimidazol-2-amine, 5,6-dichloro-;5,6-dichloro-1H-1,3-benzodiazol-2-amine
- CBNumber
- CB1206007
- Molecular Formula
- C7H5Cl2N3
- Formula Weight
- 202.04
- MOL File
- 18672-03-2.mol
5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE Property
- Melting point:
- 244-246℃
- Boiling point:
- 435.4±48.0 °C(Predicted)
- Density
- 1.665±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 8.47±0.10(Predicted)
- Appearance
- Light yellow to light brown Solid
- CAS DataBase Reference
- 18672-03-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- HCH0142863
- Product name
- 5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-AMINE
- Purity
- 98.00%
- Packaging
- 1G
- Price
- $1068.38
- Updated
- 2021/12/16
- Product number
- HCH0142863
- Product name
- 5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-AMINE
- Purity
- 98.00%
- Packaging
- 5G
- Price
- $2512.13
- Updated
- 2021/12/16
- Product number
- SC-51871
- Product name
- 5,6-dichloro-1H-benzo[d]imidazol-2-amine
- Purity
- 95
- Packaging
- 2g
- Price
- $1633
- Updated
- 2021/12/16
- Product number
- SC-51871
- Product name
- 5,6-dichloro-1H-benzo[d]imidazol-2-amine
- Purity
- 95
- Packaging
- 5g
- Price
- $2100
- Updated
- 2021/12/16
- Product number
- CM250713
- Product name
- 5,6-Dichloro-1H-benzo[d]imidazol-2-amine
- Purity
- 96%
- Packaging
- 1g
- Price
- $276
- Updated
- 2021/12/16
5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE Chemical Properties,Usage,Production
Uses
2-Amino-5,6-dichlorobenzimidazole is used as pharmaceutical intermediate.
Synthesis
5348-42-5
506-68-3
18672-03-2
Example 138: General procedure for the synthesis of 5,6-dichloro-1H-benzo[d]imidazol-2-amine from 4,5-dichloro-1,2-benzenediamine and cyanogen bromide: Cyanogen bromide (0.063 g, 0.6 mmol) was added to a mixture of acetonitrile (10 mL) and water (0.81 g, 0.562 mmol) of 4,5-dichlorobenzene-1,2-diamine (0.81 g, 0.562 mmol) at 0 °C. (2 mL) in a mixed solution of acetonitrile (10 mL) and water (2 mL). The reaction mixture was gradually warmed to room temperature with continuous stirring for 14 hours. Subsequently, saturated aqueous sodium bicarbonate solution (50 mL) was added to the reaction mixture and shaken thoroughly. The resulting solid was collected by filtration, washed with water and dried under reduced pressure to afford 5,6-dichloro-1H-benzo[d]imidazol-2-amine 0.43 g in 50% yield. Mass spectrometry (EI) analysis showed a molecular ion peak (MH+) of 203.
References
[1] Journal of Medicinal Chemistry, 1995, vol. 38, # 20, p. 4098 - 4105
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 8, p. 1252 - 1262
[3] Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 16, p. 2221 - 2224
[4] Patent: WO2008/42282, 2008, A2. Location in patent: Page/Page column 208
[5] Angewandte Chemie - International Edition, 2012, vol. 51, # 41, p. 10364 - 10367
5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE manufacturers
- Product
- 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE 18672-03-2
- Price
- US $90.00-900.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-13