DEATH RECEPTOR 4
- Product Name
- DEATH RECEPTOR 4
- Chemical Name
- DEATH RECEPTOR 4
- Synonyms
- DR4;Apo2;DRB4;HLA-DR4B;HUMAN DR4;TNFRSF10A;DR beta 4;HUMAN APO2;HUMAN TNFRSF10A;DEATH RECEPTOR 4
- CBNumber
- CB1208379
- Formula Weight
- 0
- MOL File
- Mol file
DEATH RECEPTOR 4 Property
- storage temp.
- -20°C
- form
- lyophilized
- color
- white
- biological source
- human
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
N-Bromosuccinimide Price
- Product number
- SRP3164
- Product name
- sTRAIL Receptor-1 (DR4) human
- Purity
- recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
- Packaging
- 50μG
- Price
- $369
- Updated
- 2025/07/31
- Product number
- orb528440
- Product name
- TNFRSF10A
- Packaging
- 10μg
- Price
- $290.7
- Updated
- 2021/12/16
DEATH RECEPTOR 4 Chemical Properties,Usage,Production
Uses
Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1) also known as DR4, is encoded by the gene mapped to human chromosome 8p21-22. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7kDa protein (216 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain. TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins. TRAIL-R1 contains a cytoplasmic "death domain," which can activate the cell′s apoptotic machinery. TRAIL Receptor-1/DR4 is activated by binding to either membrane anchored or soluble TRAIL/Apo2L.
Biological Activity
Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1) interacts with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and stimulate cell-death signaling pathway. Mutation of the sTRAIL-R1 gene is associated with the pathogenesis of non-Hodgkinμs lymphoma (NHL). In addition, variation of TRAIL-R1 also increases the risk of susceptibility to prostate cancer (PCa) in North Indian population.
DEATH RECEPTOR 4 Preparation Products And Raw materials
Raw materials
Preparation Products
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