3-Chloro-2-fluorobenzaldehyde
- Product Name
- 3-Chloro-2-fluorobenzaldehyde
- CAS No.
- 85070-48-0
- Chemical Name
- 3-Chloro-2-fluorobenzaldehyde
- Synonyms
- TIMTEC-BB SBB003987;3-Chloro-2-fluorobenzaldehvd;3-CHLORO-2-FLUOROBENZALDEHYDE;3-Chloro-2-Flourobenzaldehyde;2-fluoro-3-chloro-benzaldehyde;Benzaldehyde,3-chloro-2-fluoro-;3-Chloro-2-fluorobenzaldehyde97%;3-Chloro-2-fluorobenzaldehyde >3-Chloro-2-fluorobenzaldehyde 97%;13C6]-3-Chloro-2-fluorobenzaldehyde
- CBNumber
- CB1209194
- Molecular Formula
- C7H4ClFO
- Formula Weight
- 158.56
- MOL File
- 85070-48-0.mol
3-Chloro-2-fluorobenzaldehyde Property
- Boiling point:
- 214 °C (lit.)
- Density
- 1.35 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.545(lit.)
- Flash point:
- 186 °F
- storage temp.
- Inert atmosphere,2-8°C
- form
- clear liquid
- color
- Light orange to Yellow to Green
- Sensitive
- Air Sensitive
- BRN
- 5861249
- InChI
- InChI=1S/C7H4ClFO/c8-6-3-1-2-5(4-10)7(6)9/h1-4H
- InChIKey
- YAOZCMANASAVFN-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=CC(Cl)=C1F
- CAS DataBase Reference
- 85070-48-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29130000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 526606
- Product name
- 3-Chloro-2-fluorobenzaldehyde
- Purity
- 96%
- Packaging
- 1g
- Price
- $26.9
- Updated
- 2023/06/20
- Product number
- 526606
- Product name
- 3-Chloro-2-fluorobenzaldehyde
- Purity
- 96%
- Packaging
- 5g
- Price
- $102
- Updated
- 2023/06/20
- Product number
- C2127
- Product name
- 3-Chloro-2-fluorobenzaldehyde
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $96
- Updated
- 2025/07/31
- Product number
- C2127
- Product name
- 3-Chloro-2-fluorobenzaldehyde
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $286
- Updated
- 2025/07/31
- Product number
- C364205
- Product name
- 3-Chloro-2-fluorobenzaldehyde
- Packaging
- 5g
- Price
- $140
- Updated
- 2021/12/16
3-Chloro-2-fluorobenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
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Uses
3-Chloro-2-fluorobenzaldehyde is an intermediate used to synthesize small-molecule inhibitors of MDM2-p53 interaction as antitumor agents. It is also used to prepare flavonoid derivatives as selective neuromedin U 2 receptor agonists for obesity treatment.
General Description
3-Chloro-2-fluorobenzaldehyde is a fluorinated benzaldehyde derivative.
Synthesis
261723-30-2
85070-48-0
36.3 g of sodium bicarbonate and 500 g of dichloromethane were added to a 1 L four-necked flask, followed by 0.5 g of TOMO as a catalyst. The reaction mixture was cooled to 0 to 5°C with stirring. To this cooled mixture was slowly added a mixed solution of 50 g of (3-chloro-2-fluorophenyl)methanol and 100 g of dichloromethane. Next, 230 g of sodium hypochlorite solution was added slowly and dropwise. The reaction mixture was held at 0 to 5°C for 1 hour. The progress of the reaction was monitored by sampling and the reaction was stopped when the content of raw (3-chloro-2-fluorophenyl)methanol was ≤ 1%. After completion of the reaction, the mixture was left to stratify. The organic layer (dichloromethane layer) was separated and the dichloromethane was recovered by simple distillation. Finally, vacuum distillation of the remaining oil layer gave 46.1 g of 3-chloro-2-fluorobenzaldehyde with 97.5% product purity and 91% yield.
References
[1] Patent: CN104529729, 2016, B. Location in patent: Paragraph 0087; 0088
3-Chloro-2-fluorobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloro-2-fluorobenzaldehyde Suppliers
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- Belgium
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View Lastest Price from 3-Chloro-2-fluorobenzaldehyde manufacturers
- Product
- 3-Chloro-2-fluorobenzaldehyde 85070-48-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-06
- Product
- 3-Chloro-2-fluorobenzaldehyde 85070-48-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-09
- Product
- 3-Chloro-2-fluorobenzaldehyde 85070-48-0
- Price
- US $600.00-550.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100Tons
- Release date
- 2023-09-21