ChemicalBook > CAS DataBase List > 3-Chloro-2-fluorobenzaldehyde

3-Chloro-2-fluorobenzaldehyde

Product Name: 3-Chloro-2-fluorobenzaldehyde
CAS No.: 85070-48-0
Chemical Name: 3-Chloro-2-fluorobenzaldehyde
Synonyms: TIMTEC-BB SBB003987;3-Chloro-2-fluorobenzaldehvd;3-CHLORO-2-FLUOROBENZALDEHYDE;3-Chloro-2-Flourobenzaldehyde;2-fluoro-3-chloro-benzaldehyde;Benzaldehyde,3-chloro-2-fluoro-;3-Chloro-2-fluorobenzaldehyde97%;3-Chloro-2-fluorobenzaldehyde >3-Chloro-2-fluorobenzaldehyde 97%;13C6]-3-Chloro-2-fluorobenzaldehyde
CBNumber: CB1209194
Molecular Formula: C7H4ClFO
Formula Weight: 158.56
MOL File: 85070-48-0.mol

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3-Chloro-2-fluorobenzaldehyde Property

Boiling point:: 214 °C (lit.)
Density: 1.35 g/mL at 25 °C (lit.)
refractive index: n20/D 1.545(lit.)
Flash point:: 186 °F
storage temp.: Inert atmosphere,2-8°C
form: clear liquid
color: Light orange to Yellow to Green
Sensitive: Air Sensitive
BRN: 5861249
InChI: InChI=1S/C7H4ClFO/c8-6-3-1-2-5(4-10)7(6)9/h1-4H
InChIKey: YAOZCMANASAVFN-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=CC(Cl)=C1F
CAS DataBase Reference: 85070-48-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 526606
Product name: 3-Chloro-2-fluorobenzaldehyde
Purity: 96%
Packaging: 1g
Price: $26.9
Updated: 2023/06/20

Sigma-Aldrich

Product number: 526606
Product name: 3-Chloro-2-fluorobenzaldehyde
Purity: 96%
Packaging: 5g
Price: $102
Updated: 2023/06/20

TCI Chemical

Product number: C2127
Product name: 3-Chloro-2-fluorobenzaldehyde
Purity: >95.0%(GC)
Packaging: 5g
Price: $96
Updated: 2025/07/31

TCI Chemical

Product number: C2127
Product name: 3-Chloro-2-fluorobenzaldehyde
Purity: >95.0%(GC)
Packaging: 25g
Price: $286
Updated: 2025/07/31

TRC

Product number: C364205
Product name: 3-Chloro-2-fluorobenzaldehyde
Packaging: 5g
Price: $140
Updated: 2021/12/16

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3-Chloro-2-fluorobenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

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Uses

3-Chloro-2-fluorobenzaldehyde is an intermediate used to synthesize small-molecule inhibitors of MDM2-p53 interaction as antitumor agents. It is also used to prepare flavonoid derivatives as selective neuromedin U 2 receptor agonists for obesity treatment.

General Description

3-Chloro-2-fluorobenzaldehyde is a fluorinated benzaldehyde derivative.

Synthesis

261723-30-2

85070-48-0

36.3 g of sodium bicarbonate and 500 g of dichloromethane were added to a 1 L four-necked flask, followed by 0.5 g of TOMO as a catalyst. The reaction mixture was cooled to 0 to 5°C with stirring. To this cooled mixture was slowly added a mixed solution of 50 g of (3-chloro-2-fluorophenyl)methanol and 100 g of dichloromethane. Next, 230 g of sodium hypochlorite solution was added slowly and dropwise. The reaction mixture was held at 0 to 5°C for 1 hour. The progress of the reaction was monitored by sampling and the reaction was stopped when the content of raw (3-chloro-2-fluorophenyl)methanol was ≤ 1%. After completion of the reaction, the mixture was left to stratify. The organic layer (dichloromethane layer) was separated and the dichloromethane was recovered by simple distillation. Finally, vacuum distillation of the remaining oil layer gave 46.1 g of 3-chloro-2-fluorobenzaldehyde with 97.5% product purity and 91% yield.

References

[1] Patent: CN104529729, 2016, B. Location in patent: Paragraph 0087; 0088

3-Chloro-2-fluorobenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Chloro-2-fluorobenzaldehyde manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Chloro-2-fluorobenzaldehyde 85070-48-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-06

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Chloro-2-fluorobenzaldehyde 85070-48-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-09

Hebei Dangtong Import and export Co LTD

Product: 3-Chloro-2-fluorobenzaldehyde 85070-48-0
Price: US $600.00-550.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100Tons
Release date: 2023-09-21

85070-48-0, 3-Chloro-2-fluorobenzaldehydeRelated Search:

3-Hydroxybenzaldehyde Transfluthrin Florfenicol 4-Fluorobenzaldehyde Difluorochloromethane 3-CHLORO-2,4-DIFLUOROBENZOYL CHLORIDE 3-Chloro-2,4-difluorobenzoic acid 3-CHLORO-2-FLUORO-6-(TRIFLUOROMETHYL)BENZOYL CHLORIDE 3-Chloro-2-fluorobenzoic acid 3'-CHLORO-2',6'-DIFLUOROACETOPHENONE 3'-CHLORO-2'-FLUOROACETOPHENONE 3-CHLORO-2,6-DIFLUOROBENZOIC ACID 3-Chloro-2,4,5-trifluorobenzoic acid 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID 3-CHLORO-2,6-DIFLUOROBENZOYL CHLORIDE 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE 3-CHLORO-2-FLUOROBENZAMIDE 3-CHLORO-2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE

3-CHLORO-2-FLUOROBENZALDEHYDE

TIMTEC-BB SBB003987

3-Chloro-2-fluorobenzaldehyde 97%

3-Chloro-2-fluorobenzaldehyde97%

2-fluoro-3-chloro-benzaldehyde

3-Chloro-2-Flourobenzaldehyde

Benzaldehyde,3-chloro-2-fluoro-

3-Chloro-2-fluorobenzaldehyde &gt

3-Chloro-2-fluorobenzaldehyde ISO 9001：2015 REACH

3-chloro-2-fluoro-benzaldehyde,2-fluoro-3-chlorobenzaldehyde

13C6]-3-Chloro-2-fluorobenzaldehyde

3-Chloro-2-fluorobenzaldehvd

85070-48-0

850707-48-0

85-70-48-0

ClC6H3FCHO

ALDEHYDE

Organic Building Blocks

Building Blocks

Aldehydes

Carbonyl Compounds

Aromatic Aldehydes & Derivatives (substituted)

Benzaldehyde

Aryl

Building Blocks

Fluorinated

Aldehydes

Carbonyl Compounds