ChemicalBook > CAS DataBase List > EHT1864

EHT1864

Product Name
EHT1864
CAS No.
754240-09-0
Chemical Name
EHT1864
Synonyms
CS-1343;CS-1239;EHT 1864;EHT-1864 2HCl;EHT 1864, >=98%;EHT1864 USP/EP/BP;EHT-1864;EHT-1864;EHT-1864Dihydrochloride;5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride;2-(morpholin-4-ylmethyl)-5-[5-[7-(trifluoromethyl)quinolin-4-yl]sulfanylpentoxy]pyran-4-one,dihydrochloride
CBNumber
CB12095478
Molecular Formula
C25H27F3N2O4S2HCl
Formula Weight
0
MOL File
754240-09-0.mol
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EHT1864 Property

Melting point:
>195°C (dec.)
storage temp. 
2-8°C
solubility 
H2O: soluble10mg/mL, clear
form 
powder
color 
white to beige
CAS DataBase Reference
754240-09-0
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E1657
Product name
EHT 1864
Purity
≥98% (HPLC)
Packaging
10mg
Price
$689
Updated
2024/03/01
Cayman Chemical
Product number
17258
Product name
EHT 1864
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17258
Product name
EHT 1864
Purity
≥98%
Packaging
5mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
17258
Product name
EHT 1864
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
17258
Product name
EHT 1864
Purity
≥98%
Packaging
50mg
Price
$911
Updated
2024/03/01
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EHT1864 Chemical Properties,Usage,Production

Uses

EHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively. It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras. EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation. It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 μM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.

Uses

EHT 1864 is a potent Rac family GTPase inhibitor.

Uses

EHT 1864 has been used to study the regulation of the adapter protein dishevelled-1 ubiquitylation by Rac1 activity.

Biological Activity

Inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (K D values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β -amyloid peptide production in vivo .

Biochem/physiol Actions

EHT 1864 inhibits Rac function. It prevents Aβ40 and Aβ42 production in vitro without direct inhibition of g-secretase.

storage

Store at +4°C

References

[1] shutes a, onesto c, picard v, et al. specificity and mechanism of action of eht 1864, a novel small molecule inhibitor of rac family small gtpases. journal of biological chemistry, 2007, 282(49): 35666-35678.

EHT1864 Preparation Products And Raw materials

Raw materials

Preparation Products

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EHT1864 Suppliers

China 69 India 2 Switzerland 2 United Kingdom 3 United States 15 Global 91
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View Lastest Price from EHT1864 manufacturers

Career Henan Chemical Co
Product
EHT 1864 754240-09-0
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-30

754240-09-0, EHT1864Related Search:

N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine ML 141 MG-132 NSC 23766 (hydrochloride) ABT 263 Fulvestrant

  • 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride
  • EHT 1864
  • CS-1239
  • CS-1343
  • EHT-1864;EHT-1864
  • EHT-1864 2HCl
  • 2-(4-morpholinylmethyl)-5-[[5-[[7-(trifluoromethyl)-4-quinolinyl]thio]pentyl]oxy]-4H-pyran-4-one,hydrochloride (1:2)
  • EHT 1864, >=98%
  • 2-(morpholin-4-ylmethyl)-5-[5-[7-(trifluoromethyl)quinolin-4-yl]sulfanylpentoxy]pyran-4-one,dihydrochloride
  • EHT1864 USP/EP/BP
  • 4H-Pyran-4-one,2-(4-morpholinylmethyl)-5-[[5-[[7-(trifluoromethyl)-4-quinolinyl]thio]pentyl]oxy]-,hydrochloride (1:2)
  • 2-(Morpholinomethyl)-5-((5-((7-(trifluoromethyl)quinolin-4-yl)thio)pentyl)oxy)-4H-pyran-4-one dihydrochloride
  • EHT-1864Dihydrochloride
  • 754240-09-0
  • C25H29Cl2F3N2O4S
  • C25H27F3N2O4S2HCl
  • Inhibitors