(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate

ChemicalBook > CAS DataBase List > (OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate

(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate

Product Name: (OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
CAS No.: 476310-60-8
Chemical Name: (OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
Synonyms: VO-Ohpic;VO Ohpic;VO-OHpic (hydrate);VO-OHpic trihydrate;VO-OHpic (PTEN Inhibitor);VO-OHpic trihydrate >=98% (HPLC), solid;(OC-6-45)-aqua(3-Hydroxy-2-pyridinecarboxylato-kappaN1,kappaO2)[3-(hydroxy-kappaO)-2-pyridinecarboxylato(2-)-kappaO2]oxovanadate(1-) hydrogen trihydrate;(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
CBNumber: CB12096521
Molecular Formula: C12H8N2O7V.3H2O
Formula Weight: 397.189
MOL File: 476310-60-8.mol

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(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Property

storage temp.: -20°C
solubility: DMSO: >10mg/mL
form: solid
color: gray

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V8639
Product name: VO-OHpic trihydrate
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $252
Updated: 2024/03/01

Cayman Chemical

Product number: 10009965
Product name: VO-OHpic (hydrate)
Purity: ≥95%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 10009965
Product name: VO-OHpic (hydrate)
Purity: ≥95%
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 10009965
Product name: VO-OHpic (hydrate)
Purity: ≥95%
Packaging: 10mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 10009965
Product name: VO-OHpic (hydrate)
Purity: ≥95%
Packaging: 25mg
Price: $317
Updated: 2024/03/01

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(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Chemical Properties,Usage,Production

Uses

VO-?OHPIC Trihydrate is used to inactivate tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (Pten) which induces a respons that opposes tumorigeneis.

Uses

VO-OHpic trihydrate has been used in studying the role of phosphatase and tensin homolog (PTEN) in polycomb repressive complex 2 (PRC2)-mediated apoptosis. It also has been used as a PTEN inhibitor to study the neuroprotective effect of melatonin in amyloid beta (Aβ)-induced neurotoxicity via PTEN pathway.

General Description

VO-OHpic is a vanadium complex. VO-OHpic might act as a possible pro-senescence anti-cancer drug for treating cancers with reduced phosphatase and tensin homolog (PTEN) expression. It blocks cell viability, cell proliferation, colony formation and induced senescence-associated β-galactosidase activity in Hep3B cells.

Biochem/physiol Actions

VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor.

(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Suppliers

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476310-60-8, (OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrateRelated Search:

Dipotassium hydrogen phosphate trihydrate Lead acetate trihydrate

(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate

VO-OHpic trihydrate

VO Ohpic

VO-Ohpic

VO-OHpic (PTEN Inhibitor)

VO-OHpic (hydrate)

(OC-6-45)-aqua(3-Hydroxy-2-pyridinecarboxylato-kappaN1,kappaO2)[3-(hydroxy-kappaO)-2-pyridinecarboxylato(2-)-kappaO2]oxovanadate(1-) hydrogen trihydrate

VO-OHpic trihydrate >=98% (HPLC), solid

476310-60-8

C12H9N2O8V3H2OH

C12H9N2O8VH3H2O

C12H16N2O11V