ChemicalBook > CAS DataBase List > (OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate

(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate

Product Name: (OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
CAS No.: 476310-60-8
Chemical Name: (OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
Synonyms: VO-Ohpic;VO Ohpic;VO-OHpic (hydrate);VO-OHpic trihydrate;Hydrido(oxo)vanadium;VO-OHpic (PTEN Inhibitor);VO-Ohpic trihydrate (VO-Ohpic;VO-Ohpic trihydrate, 10 mM in DMSO;VO-OHpic trihydrate, PTEN inhibitor;VO-OHpic trihydrate >=98% (HPLC), solid
CBNumber: CB12096521
Molecular Formula: C12H8N2O7V.3H2O
Formula Weight: 397.189
MOL File: 476310-60-8.mol

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(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Property

storage temp.: -20°C
solubility: DMSO: >10mg/mL
form: solid
color: gray
InChI: InChI=1S/2C6H5NO3.3H2O.O.V.H/c2*8-4-2-1-3-7-5(4)6(9)10;;;;;;/h2*1-3,8H,(H,9,10);3*1H2;;;/q;;;;;;+3;/p-3
InChIKey: XSVSRTSHXJGGKW-UHFFFAOYSA-K
SMILES: O.O.C1=CN=C2C(=O)O[V]([H])(=O)(OC(=O)C3C(O)=CC=CN=3)OC2=C1.O

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V8639
Product name: VO-OHpic trihydrate
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $190.4
Updated: 2025/07/31

Cayman Chemical

Product number: 10009965
Product name: VO-OHpic (hydrate)
Purity: ≥95%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 10009965
Product name: VO-OHpic (hydrate)
Purity: ≥95%
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 10009965
Product name: VO-OHpic (hydrate)
Purity: ≥95%
Packaging: 10mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 10009965
Product name: VO-OHpic (hydrate)
Purity: ≥95%
Packaging: 25mg
Price: $317
Updated: 2024/03/01

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(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Chemical Properties,Usage,Production

Uses

VO-?OHPIC Trihydrate is used to inactivate tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (Pten) which induces a respons that opposes tumorigeneis.

Uses

VO-OHpic trihydrate has been used in studying the role of phosphatase and tensin homolog (PTEN) in polycomb repressive complex 2 (PRC2)-mediated apoptosis. It also has been used as a PTEN inhibitor to study the neuroprotective effect of melatonin in amyloid beta (Aβ)-induced neurotoxicity via PTEN pathway.

General Description

VO-OHpic is a vanadium complex. VO-OHpic might act as a possible pro-senescence anti-cancer drug for treating cancers with reduced phosphatase and tensin homolog (PTEN) expression. It blocks cell viability, cell proliferation, colony formation and induced senescence-associated β-galactosidase activity in Hep3B cells.

Biochem/physiol Actions

VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor.

in vivo

PTEN is inhibited in mice by intra-peritoneal injection of VO-OHpic (10 μg/kg) 30 min before ischemia and then exposed them to 30 min of ischemia and 120 min of reperfusion. At the end of the experiment, myocardial infarct size is measured by triphenyltetrazolium chloride (TTC). Myocardial infarct size is significantly decreased in VO-treated mice (25±6 vs. 56±5 %, n=7, P<0.01). There is no difference in the area at risk between these two groups (46±3 vs. 57±3 %, n=7, P>0.05)^[3].

(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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476310-60-8, (OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrateRelated Search:

Dipotassium hydrogen phosphate trihydrate Lead acetate trihydrate

(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate

VO-OHpic trihydrate

VO Ohpic

VO-Ohpic

VO-OHpic (PTEN Inhibitor)

VO-OHpic (hydrate)

(OC-6-45)-aqua(3-Hydroxy-2-pyridinecarboxylato-kappaN1,kappaO2)[3-(hydroxy-kappaO)-2-pyridinecarboxylato(2-)-kappaO2]oxovanadate(1-) hydrogen trihydrate

VO-OHpic trihydrate >=98% (HPLC), solid

Hydrido(oxo)vanadium

VO-OHpic trihydrate, PTEN inhibitor

VO-Ohpic trihydrate, 10 mM in DMSO

VO-Ohpic trihydrate (VO-Ohpic

476310-60-8

C12H9N2O8V3H2OH

C12H9N2O8VH3H2O

C12H16N2O11V