(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
- Product Name
- (OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
- CAS No.
- 476310-60-8
- Chemical Name
- (OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
- Synonyms
- VO-Ohpic;VO Ohpic;VO-OHpic (hydrate);VO-OHpic trihydrate;VO-OHpic (PTEN Inhibitor);VO-OHpic trihydrate >=98% (HPLC), solid;(OC-6-45)-aqua(3-Hydroxy-2-pyridinecarboxylato-kappaN1,kappaO2)[3-(hydroxy-kappaO)-2-pyridinecarboxylato(2-)-kappaO2]oxovanadate(1-) hydrogen trihydrate;(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
- CBNumber
- CB12096521
- Molecular Formula
- C12H8N2O7V.3H2O
- Formula Weight
- 397.189
- MOL File
- 476310-60-8.mol
(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Property
- storage temp.
- -20°C
- solubility
- DMSO: >10mg/mL
- form
- solid
- color
- gray
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- V8639
- Product name
- VO-OHpic trihydrate
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $252
- Updated
- 2024/03/01
- Product number
- 10009965
- Product name
- VO-OHpic (hydrate)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 10009965
- Product name
- VO-OHpic (hydrate)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 10009965
- Product name
- VO-OHpic (hydrate)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- 10009965
- Product name
- VO-OHpic (hydrate)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $317
- Updated
- 2024/03/01
(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Chemical Properties,Usage,Production
Uses
VO-?OHPIC Trihydrate is used to inactivate tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (Pten) which induces a respons that opposes tumorigeneis.
Uses
VO-OHpic trihydrate has been used in studying the role of phosphatase and tensin homolog (PTEN) in polycomb repressive complex 2 (PRC2)-mediated apoptosis. It also has been used as a PTEN inhibitor to study the neuroprotective effect of melatonin in amyloid beta (Aβ)-induced neurotoxicity via PTEN pathway.
General Description
VO-OHpic is a vanadium complex. VO-OHpic might act as a possible pro-senescence anti-cancer drug for treating cancers with reduced phosphatase and tensin homolog (PTEN) expression. It blocks cell viability, cell proliferation, colony formation and induced senescence-associated β-galactosidase activity in Hep3B cells.
Biochem/physiol Actions
VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor.