ChemicalBook > CAS DataBase List > Methyl 2-aminopyridine-4-carboxylate
Methyl 2-aminopyridine-4-carboxylate
- Product Name
- Methyl 2-aminopyridine-4-carboxylate
- CAS No.
- 6937-03-7
- Chemical Name
- Methyl 2-aminopyridine-4-carboxylate
- Synonyms
- METHYL 2-AMINOISONICOTINATE;2-Aminopyridine-4-carboxylic acid methyl ester;NSC 40138;Methyl 2-aMinopy;CHEMBRDG-BB 4015127;2-aminopyridine-4-carboxyL;2- aMinoMethyl isonicotinate;Methyl2-Aminoisonicotinate>Methyl 2-aminoisonicotinate 98%;Methyl 2-aminoisonicotinate, 98%
- CBNumber
- CB1212183
- Molecular Formula
- C7H8N2O2
- Formula Weight
- 152.15
- MOL File
- 6937-03-7.mol
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Methyl 2-aminopyridine-4-carboxylate Property
- Melting point:
- 144-148 °C
- Boiling point:
- 296.1±20.0 °C(Predicted)
- Density
- 1.238±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform
- pka
- 4.89±0.11(Predicted)
- form
- Crystalline Powder
- color
- White to brown
- Water Solubility
- Insoluble in water.
- BRN
- 128642
- InChI
- InChI=1S/C7H8N2O2/c1-11-7(10)5-2-3-9-6(8)4-5/h2-4H,1H3,(H2,8,9)
- InChIKey
- SVWWNEYBEFASMP-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=CC(C(OC)=O)=C1
- CAS DataBase Reference
- 6937-03-7(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-41-20/22
- Safety Statements
- 26-36-26/36-39-36/37/39-22
- HazardClass
- IRRITANT
- HS Code
- 29333990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 704482
- Product name
- Methyl 2-aminopyridine-4-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $76.3
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 704482
- Product name
- Methyl 2-aminopyridine-4-carboxylate
- Purity
- 97%
- Packaging
- 5G
- Price
- $137
- Updated
- 2023/06/20
TCI Chemical
- Product number
- M2172
- Product name
- Methyl 2-Aminoisonicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $30
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M2172
- Product name
- Methyl 2-Aminoisonicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $88
- Updated
- 2025/07/31
TRC
- Product number
- M286840
- Product name
- Methyl 2-Aminoisonicotinate
- Packaging
- 2g
- Price
- $60
- Updated
- 2021/12/16
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Methyl 2-aminopyridine-4-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Tan Solid
Uses
Methyl 2-aminopyridine-4-carboxylate is an inhibitor of nitrogen monoxide synthetase.
Uses
A nitrogen monoxide synthetase inhibitor.
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y
Synthesis
67-56-1
13362-28-2
6937-03-7
The general procedure for the synthesis of methyl 2-aminoisonicotinate from methanol and 2-aminoisonicotinic acid was as follows: 2-aminoisonicotinic acid (207 g, 1.5 mol) was dissolved in methanol (1.8 L) to prepare a solution. The solution was slowly added dropwise to thionyl chloride (238 g, 2 mol) at 50 °C. After the dropwise addition was completed, the reaction temperature was maintained at 50 °C and the reaction mixture continued to be stirred for 5 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue, saturated aqueous sodium carbonate solution was added and the pH was adjusted to 9-10 to make the reaction mixture basic. Subsequently, the mixed solution was extracted with dichloromethane (300 ml each time for 3 times). The organic layers were combined and dried with anhydrous sodium sulfate. Finally, the solvent was removed by concentration to give methyl 2-aminoisonicotinate (189 g, 83% yield) as a yellow solid. The structure of the product was confirmed by 1H-NMR (d6-DMSO, 300 MHz): δ 3.96 (s, 3H); 7.14 (d, 1H); 7.49 (br, 1H); 8.07 (d, 1H); 8.18 (br, 2H, NH).
References
[1] European Journal of Medicinal Chemistry, 2013, vol. 61, p. 26 - 40
[2] Journal of the American Chemical Society, 2018, vol. 140, # 9, p. 3322 - 3330
[3] Chemistry - A European Journal, 2012, vol. 18, # 27, p. 8498 - 8507
[4] Patent: EP3018125, 2016, A1. Location in patent: Paragraph 0515-0518
[5] Russian Journal of Organic Chemistry, 2015, vol. 51, # 5, p. 744 - 745
Methyl 2-aminopyridine-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-aminopyridine-4-carboxylate manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- Methyl 2-aminopyridine-4-carboxylate 6937-03-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-10
Shaanxi Dideu New Materials Co. Ltd
- Product
- Methyl 2-aminopyridine-4-carboxylate 6937-03-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-01
Hebei Zhanyao Biotechnology Co. Ltd
- Product
- Methyl 2-aminopyridine-4-carboxylate 6937-03-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-13
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