BCTC

ChemicalBook > CAS DataBase List > BCTC

Product Name: BCTC
CAS No.: 393514-24-4
Chemical Name: BCTC
Synonyms: BCTC;N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide;4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide;1-Piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-;4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-diMethylethyl)phenyl]-1-piperazinecarboxaMide (BCTC)
CBNumber: CB12122071
Molecular Formula: C20H25ClN4O
Formula Weight: 372.89
MOL File: 393514-24-4.mol

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BCTC Property

Melting point:: 150-152℃
Boiling point:: 561.6±50.0 °C(Predicted)
Density: 1.229±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: >10mg/mL
pka: 13.95±0.70(Predicted)
form: powder
color: white to beige
Sensitive: Light Sensitive
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stord at -20°C for up to 2 months.
InChIKey: ROGUAPYLUCHQGK-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0355
Product name: BCTC
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $96.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0355
Product name: BCTC
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $314
Updated: 2024/03/01

Alfa Aesar

Product number: J67361
Product name: BCTC, 98%
Packaging: 50mg
Price: $507
Updated: 2021/12/16

Alfa Aesar

Product number: J67361
Product name: BCTC, 98%
Packaging: 10mg
Price: $172
Updated: 2021/12/16

Cayman Chemical

Product number: 10006309
Product name: BCTC
Purity: ≥98%
Packaging: 5mg
Price: $41
Updated: 2024/03/01

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BCTC Chemical Properties,Usage,Production

Description

BCTC (393514-24-4) is a vanilloid receptor I (TRPV1) blocker, IC50 = 35 nM for capsaicin-induced and 6 nM for acid-induced TRPV1 activation. Displays analgesic activity in rat models of neuropathic pain. BCTC is orally active and cell permeable.

Uses

BCTC is a antagonists of TRPA1 and TRPV1, a non-selective cation channel gated by noxious heat, vanilloids and extracellular protons. BCTC inhibits both capsaicin and proton activation.

Definition

ChEBI: 1-piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-n-[4-(1,1-dimethylethyl)phenyl]- is a member of piperazines and a member of pyridines.

storage

Room temperature

References

1) Valenzano et al. (2003), N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties; J. Pharmacol. Exp. Ther., 306 377 2) Pomonis et al. (2003), N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain; J. Pharmacol. Exp. Ther., 306 387

BCTC Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BCTC manufacturers

Career Henan Chemical Co

Product: BCTC 393514-24-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10t
Release date: 2019-12-20

393514-24-4, BCTCRelated Search:

Oleoyl Ethanolamide AMG 9810 4'-CHLORO-3-METHOXYCINNAMANILIDE Evodiamine Eugenol Capsaicin 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Dofetilide A 967079 VERATRIDINE 1,3,5-Tri-tert-butylbenzene PSY-279 OLDA AA-5-HT IBTU PPAHV ISOVELLERAL JYL-273

BCTC

4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide

4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-diMethylethyl)phenyl]-1-piperazinecarboxaMide (BCTC)

N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide

1-Piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-

393514-24-4

Vanilloid/TRPV channel