4,4-Difluorocyclohexanol
- Product Name
- 4,4-Difluorocyclohexanol
- CAS No.
- 22419-35-8
- Chemical Name
- 4,4-Difluorocyclohexanol
- Synonyms
- 4,4-difluorocyclohexanol;Cyclohexanol, 4,4-difluoro-;4,4-
Difluorocyclohexanol;1,1-Difluoro-4-hydroxycyclohexane - CBNumber
- CB12123210
- Molecular Formula
- C6H10F2O
- Formula Weight
- 136.14
- MOL File
- 22419-35-8.mol
4,4-Difluorocyclohexanol Property
- Melting point:
- 60-65°C
- Boiling point:
- 160.6±40.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.14±0.40(Predicted)
- form
- powder to lump
- color
- White to Orange to Green
- InChI
- InChI=1S/C6H10F2O/c7-6(8)3-1-5(9)2-4-6/h5,9H,1-4H2
- InChIKey
- XTJZBCBHCPQASK-UHFFFAOYSA-N
- SMILES
- C1(O)CCC(F)(F)CC1
- CAS DataBase Reference
- 22419-35-8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 740748
- Product name
- 4,4-Difluorocyclohexanol
- Purity
- 95%
- Packaging
- 500mg
- Price
- $125
- Updated
- 2023/06/20
- Product number
- D5540
- Product name
- 4,4-Difluorocyclohexanol
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $43
- Updated
- 2026/03/19
- Product number
- D5540
- Product name
- 4,4-Difluorocyclohexanol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $144
- Updated
- 2026/03/19
- Product number
- D442370
- Product name
- 4,4-Difluorocyclohexanol
- Packaging
- 2.5g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 2202-3-44
- Product name
- 4,4-Difluorocyclohexanol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
4,4-Difluorocyclohexanol Chemical Properties,Usage,Production
Chemical Properties
viscous liquid
Uses
4,4-Difluorocyclohexanol is a reagent used in the clearance of adenosine inhibitors of bacterial NAD+-dependent DNA ligase.
Synthesis
22515-18-0
22419-35-8
General procedure for the synthesis of 4,4-difluorocyclohexanol from 4,4-difluorocyclohexanone: Sodium borohydride (460 mg, 12.17 mmol) was added to a cold solution of 4,4-difluorocyclohexanone (907 mg, 6.76 mmol) in methanol (22 mL) under the conditions of an ice water bath. The reaction mixture was stirred for 5 minutes and then allowed to warm slowly to room temperature and continued stirring for 1 hour. Upon completion of the reaction, the reaction was quenched with water (11 mL) and stirred for 30 minutes. Subsequently, the solvent was removed by concentration on a rotary evaporator and the residue was partitioned between water (11 mL) and dichloromethane (10 mL). The aqueous layer was separated and extracted with dichloromethane (3 x 10 mL). All organic layers were combined, dried with anhydrous magnesium sulfate, filtered and the solvent was concentrated to give the target product 4,4-difluorocyclohexanol (839 mg, 91% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 4.03-3.82 (m, 1H), 2.26-1.98 (m, 2H), 1.98-1.64 (m, 6H), 1.43 (d, J = 3.6 Hz, 1H).
References
[1] Patent: WO2015/164520, 2015, A1. Location in patent: Page/Page column 63
[2] Patent: WO2016/196776, 2016, A2. Location in patent: Paragraph 001239
[3] Patent: EP2213675, 2010, A1. Location in patent: Page/Page column 41
[4] Patent: US2015/94328, 2015, A1. Location in patent: Paragraph 0427-0429
[5] Patent: WO2015/49574, 2015, A1. Location in patent: Page/Page column 49; 50
4,4-Difluorocyclohexanol Preparation Products And Raw materials
Raw materials
Preparation Products
4,4-Difluorocyclohexanol Suppliers
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View Lastest Price from 4,4-Difluorocyclohexanol manufacturers
- Product
- 4,4-Difluorocyclohexanol 22419-35-8
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2025-09-29
- Product
- 4,4-Difluorocyclohexanol 22419-35-8
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-17
- Product
- 4,4-Difluorocyclohexanol 22419-35-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09