4,4-DIFLUOROCYCLOHEXANONE
- Product Name
- 4,4-DIFLUOROCYCLOHEXANONE
- CAS No.
- 22515-18-0
- Chemical Name
- 4,4-DIFLUOROCYCLOHEXANONE
- Synonyms
- 4,4-Difluorocyclohexan-1-one;uorocycL;4,4-DIFLUOROCYCLOHEXANONE;4,4-difluro-cyclohexanone;Cyclohexanone, 4,4-difluoro-;1,1,-Difluoro-4-oxocyclohexane;4,4-
Difluorocyclohexanone;4,4-Difluorocyclohexanone(WX900093);TIANFU CHEM --4,4-DIFLUOROCYCLOHEXANONE - CBNumber
- CB5149175
- Molecular Formula
- C6H8F2O
- Formula Weight
- 134.12
- MOL File
- 22515-18-0.mol
4,4-DIFLUOROCYCLOHEXANONE Property
- Melting point:
- 35-36°C
- Boiling point:
- 157.4±40.0 °C(Predicted)
- Density
- 1.14g/ml
- Flash point:
- 65°C
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- form
- low melting solid
- Appearance
- white solid
- Water Solubility
- Insoluble in water.
- InChI
- InChI=1S/C6H8F2O/c7-6(8)3-1-5(9)2-4-6/h1-4H2
- InChIKey
- NYYSPVRERVXMLJ-UHFFFAOYSA-N
- SMILES
- C1(=O)CCC(F)(F)CC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 711403
- Product name
- 4,4-Difluorocyclohexanone
- Purity
- 97%
- Packaging
- 250mg
- Price
- $190.95
- Updated
- 2025/07/31
- Product number
- D4516
- Product name
- 4,4-Difluorocyclohexanone
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $52
- Updated
- 2025/07/31
- Product number
- D4516
- Product name
- 4,4-Difluorocyclohexanone
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $156
- Updated
- 2025/07/31
- Product number
- D447535
- Product name
- 4,4-Difluorocyclohexanone
- Packaging
- 10g
- Price
- $970
- Updated
- 2021/12/16
- Product number
- HCH0036812
- Product name
- 4,4-DIFLUOROCYCLOHEXANONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1129.13
- Updated
- 2021/12/16
4,4-DIFLUOROCYCLOHEXANONE Chemical Properties,Usage,Production
Chemical Properties
White to brown solid
Uses
4,4-Difluorocyclohexanone is used as a pharmaceutical intermediate.
Synthesis
176251-49-3
22515-18-0
4.3. Synthesis of 4,4-difluorocyclohexanone (8): the acetonide 7 (20.0 g, 112.2 mmol) was suspended in 20% HCl aqueous solution (16 mL) and stirred vigorously for 3 hours at 100 °C. After the reaction was completed, it was cooled to room temperature and NaCl (~3 g) was added to the aqueous phase to dissolve it. Subsequently, the aqueous phase was extracted with CH2Cl2 (3 x 50 mL). The organic phases were combined, washed with 50 mL of water, dried over Na2SO4, and the solvent was slowly evaporated under reduced pressure at 20 °C. Due to the extreme instability of the product, the material initially obtained was a 1:1 mixture of product 8 and raw material 5. After repeating the above operation, the ratio of 8 to 5 in the mixture was increased to 7:3. After a number of repetitions, the final product 8 was obtained with 95% purity as white crystals (11.0 g, 71% yield) with a melting point of 31-32°C. The product was then dried over 50 mL of water and evaporated slowly at 20°C under reduced pressure.
References
[1] Organic Letters, 2013, vol. 15, # 5, p. 1088 - 1091
[2] Tetrahedron, 2013, vol. 69, # 20, p. 4066 - 4075
[3] Patent: US2006/293392, 2006, A1. Location in patent: Page/Page column 51
[4] Patent: WO2008/7930, 2008, A1. Location in patent: Page/Page column 28
[5] Patent: WO2009/48547, 2009, A1. Location in patent: Page/Page column 40
4,4-DIFLUOROCYCLOHEXANONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,4-DIFLUOROCYCLOHEXANONE manufacturers
- Product
- 4,4-DIFLUOROCYCLOHEXANONE 22515-18-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09
- Product
- 4,4-DIFLUOROCYCLOHEXANONE 22515-18-0
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-08