3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE

Product Name: 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE
CAS No.: 163457-23-6
Chemical Name: 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE
Synonyms: 3,3-DIFLUOROPYRROLIDINE HCL;GOSO-005;3,3-DifL;uoropyrroL;idine hydrochL;3,3-Difluoropyrrolidine h...;1-Aza-3,3-difluorocyclopentane;3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE;3,3-DifluoropyrrolidineHydrochloride>3,3-Difl uoropyrrol [dine hydrochloride
CBNumber: CB3429107
Molecular Formula: C4H7F2N.ClH
Formula Weight: 143.56
MOL File: 163457-23-6.mol

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3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Property

Melting point:: 128-130°C
storage temp.: Inert atmosphere,Room Temperature
form: solid
color: White to off white
Sensitive: Hygroscopic
InChI: InChI=1S/C4H7F2N.ClH/c5-4(6)1-2-7-3-4;/h7H,1-3H2;1H
InChIKey: YYVPZQADFREIFR-UHFFFAOYSA-N
SMILES: N1CCC(F)(F)C1.[H]Cl
CAS DataBase Reference: 163457-23-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT, HYGROSCOPIC
HS Code: 29339900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 694509
Product name: 3,3-Difluoropyrrolidine hydrochloride
Purity: 97%
Packaging: 1g
Price: $114
Updated: 2025/07/31

Sigma-Aldrich

Product number: 694509
Product name: 3,3-Difluoropyrrolidine hydrochloride
Purity: 97%
Packaging: 250mg
Price: $49.1
Updated: 2023/06/20

TCI Chemical

Product number: D4315
Product name: 3,3-Difluoropyrrolidine Hydrochloride
Purity: >98.0%(T)
Packaging: 200mg
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: D4315
Product name: 3,3-Difluoropyrrolidine Hydrochloride
Purity: >98.0%(T)
Packaging: 1g
Price: $140
Updated: 2025/07/31

TRC

Product number: D445810
Product name: 3,3-Difluoropyrrolidine hydrochloride
Packaging: 2.5g
Price: $420
Updated: 2021/12/16

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3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Beige solid

Uses

3,3-Difluoropyrrolidine hydrochloride can be used as a building block in the synthesis of:

Triazole substituted prolyl difluoropyrrolidines as potential inhibitors of dipeptidyl peptidase-4.
Dual leucine zipper kinase (DLK) inhibitors.

It can be also used as a reactant in the preparation of cyclic and acyclic β-aminofluoroalkenes via allylic amination using the Pd catalyst.

Synthesis

195447-25-7

163457-23-6

Part C: 1,1-dimethylethyl 3,3-difluoropyrrolidine-1-carboxylate (0.868 g, 4.19 mmol) was dissolved in 1.5 mL of 1,4-dioxane and cooled to 0°C. A 1,4-dioxane solution (11 mL, 44 mmol) of 4 M hydrogen chloride was slowly added with stirring. The reaction mixture was continued to be stirred at 0°C for 40 minutes, then brought to room temperature and stirred for 1 hour. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to afford 0.65 g of 3,3-difluoropyrrolidine hydrochloride (100% yield). The product was characterized by 1H-NMR (CD3OD): δ 3.54 (2H, t, J = 11.9 Hz), 3.43 (2H, t, J = 7.8 Hz), 2.40 (2H, m).

References

[1] Patent: US2004/186134, 2004, A1. Location in patent: Page 241
[2] Patent: US2018/237472, 2018, A1. Location in patent: Paragraph 0170; 0171
[3] Patent: WO2017/17630, 2017, A1. Location in patent: Page/Page column 57

3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Suppliers

Americas 1 Canada 2 China 227 Europe 2 Germany 4 India 9 Italy 1 Japan 2 Switzerland 1 United Kingdom 12 United States 36 Global 297

BTC Pharmaceutical CO. Ltd

Tel: 0513-68015397;15716293042 18862997610;18862996710
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J & K SCIENTIFIC LTD.

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ITIC MEDCHEM(SUZHOU) CO.,LTD.

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Beijing Ouhe Technology Co., Ltd

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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View Lastest Price from 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3,3-Difluoropyrrolidine HCl 163457-23-6
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-24

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3,3-Difluoropyrrolidine Hydrochloride 163457-23-6
Price: US $0.00/G
Min. Order: 5G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-03

Henan Aochuang Chemical Co.,Ltd.

Product: 3,3-Difluoropyrrolidine hydrochloride 163457-23-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

163457-23-6, 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDERelated Search:

(3r,4r)-n-cbz-3,4-difluoropyrrolidine hydrochloride BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE 1-BOC-3,3-DIFLUOROPYRROLIDINE N-BOC-4,4-difluoro-L-proline 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE FMOC-D-PRO(4,4-DIFLUORO) 4,4-DIFLUORO-D-PROLINAMIDE HYDROCHLORIDE 3,3,4,4-TETRAFLUOROPYRROLIDINE HYDROCHLORIDE 1-CBZ-3,3-DIFLUOROPYRROLIDINE BOC-4,4-DIFLUORO-L-PROLINAMIDE 1-BENZYL-3,3-DIFLUORO-PYRROLIDINE-2,5-DIONE (2S)-Fmoc-4,4-difluoro-pyrrolidine-2-carboxylic acid TETRAFLUOROSUCCINIMIDE 1-BENZYL-3,3-DIFLUORO-PYRROLIDINE BOC-D-PRO(4,4-DIFLUORO) (8aS)-7,7-difluorooctahydropyrrolo[1,2-a]pyrazine tert-butyl (2S)-2-cyano-4,4-difluoropyrrolidine-1-carboxylate

3,3-<WBR>Difluoropyrrolidine hydrochloride

3,3-Difluoropyrrolidine hydrochloride 97%

GOSO-005

cis-1-Methyl-2-oxo-1,2-dihydro-quinoline-5-carboxylic acid

3,3-DIFLUOROPYRROLIDINE HCL

3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE

Pyrrolidine, 3,3-difluoro-, hydrochloride (1:1)

1-Aza-3,3-difluorocyclopentane

3,3-Difluoropyrrolidine h...

3,3-DifluoropyrrolidineHydrochloride&gt

3,3-DifL

idine hydrochL

uoropyrroL

3,3-difluoro-Pyrrolidine hydrochloride (1:1)

3,3-Difl uoropyrrol [dine hydrochloride

163457-23-6

C4H7F2NClH

C4H8ClF2N

C4H7F2N.HCl

C5H7F2NHCl

Fluorinated Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Heterocyclic Fluorinated Building Blocks

Other Fluorinated Heterocycles

Building Blocks

C4 to C10

Chemical Synthesis

Heterocycles

Miscellaneous Reagents

pharmacetical

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrrolidines

PyrrolidinesHeterocyclic Building Blocks

1