ChemicalBook > CAS DataBase List > 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE

3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE

Product Name: 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE
CAS No.: 163457-23-6
Chemical Name: 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE
Synonyms: 3,3-DIFLUOROPYRROLIDINE HCL;GOSO-005;3,3-DifL;uoropyrroL;idine hydrochL;3,3-Difluoropyrrolidine h...;1-Aza-3,3-difluorocyclopentane;3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE;3,3-DifluoropyrrolidineHydrochloride>3,3-Difl uoropyrrol [dine hydrochloride
CBNumber: CB3429107
Molecular Formula: C4H7F2N.ClH
Formula Weight: 143.56
MOL File: 163457-23-6.mol

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3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Property

Melting point:: 128-130°C
storage temp.: Inert atmosphere,Room Temperature
form: solid
color: White to off white
Sensitive: Hygroscopic
InChI: InChI=1S/C4H7F2N.ClH/c5-4(6)1-2-7-3-4;/h7H,1-3H2;1H
InChIKey: YYVPZQADFREIFR-UHFFFAOYSA-N
SMILES: N1CCC(F)(F)C1.[H]Cl
CAS DataBase Reference: 163457-23-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT, HYGROSCOPIC
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 694509
Product name: 3,3-Difluoropyrrolidine hydrochloride
Purity: 97%
Packaging: 1g
Price: $114
Updated: 2025/07/31

Sigma-Aldrich

Product number: 694509
Product name: 3,3-Difluoropyrrolidine hydrochloride
Purity: 97%
Packaging: 250mg
Price: $49.1
Updated: 2023/06/20

TCI Chemical

Product number: D4315
Product name: 3,3-Difluoropyrrolidine Hydrochloride
Purity: >98.0%(T)
Packaging: 200mg
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: D4315
Product name: 3,3-Difluoropyrrolidine Hydrochloride
Purity: >98.0%(T)
Packaging: 1g
Price: $140
Updated: 2025/07/31

TRC

Product number: D445810
Product name: 3,3-Difluoropyrrolidine hydrochloride
Packaging: 2.5g
Price: $420
Updated: 2021/12/16

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3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Beige solid

Uses

3,3-Difluoropyrrolidine hydrochloride can be used as a building block in the synthesis of:

Triazole substituted prolyl difluoropyrrolidines as potential inhibitors of dipeptidyl peptidase-4.
Dual leucine zipper kinase (DLK) inhibitors.

It can be also used as a reactant in the preparation of cyclic and acyclic β-aminofluoroalkenes via allylic amination using the Pd catalyst.

Synthesis

195447-25-7

163457-23-6

Part C: 1,1-dimethylethyl 3,3-difluoropyrrolidine-1-carboxylate (0.868 g, 4.19 mmol) was dissolved in 1.5 mL of 1,4-dioxane and cooled to 0°C. A 1,4-dioxane solution (11 mL, 44 mmol) of 4 M hydrogen chloride was slowly added with stirring. The reaction mixture was continued to be stirred at 0°C for 40 minutes, then brought to room temperature and stirred for 1 hour. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to afford 0.65 g of 3,3-difluoropyrrolidine hydrochloride (100% yield). The product was characterized by 1H-NMR (CD3OD): δ 3.54 (2H, t, J = 11.9 Hz), 3.43 (2H, t, J = 7.8 Hz), 2.40 (2H, m).

References

[1] Patent: US2004/186134, 2004, A1. Location in patent: Page 241
[2] Patent: US2018/237472, 2018, A1. Location in patent: Paragraph 0170; 0171
[3] Patent: WO2017/17630, 2017, A1. Location in patent: Page/Page column 57

3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Suppliers

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View Lastest Price from 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3,3-Difluoropyrrolidine HCl 163457-23-6
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-24

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3,3-Difluoropyrrolidine Hydrochloride 163457-23-6
Price: US $0.00/G
Min. Order: 5G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-03

Henan Aochuang Chemical Co.,Ltd.

Product: 3,3-Difluoropyrrolidine hydrochloride 163457-23-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

163457-23-6, 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDERelated Search:

(3r,4r)-n-cbz-3,4-difluoropyrrolidine hydrochloride BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE 1-BOC-3,3-DIFLUOROPYRROLIDINE N-BOC-4,4-difluoro-L-proline 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE FMOC-D-PRO(4,4-DIFLUORO) 4,4-DIFLUORO-D-PROLINAMIDE HYDROCHLORIDE 3,3,4,4-TETRAFLUOROPYRROLIDINE HYDROCHLORIDE 1-CBZ-3,3-DIFLUOROPYRROLIDINE BOC-4,4-DIFLUORO-L-PROLINAMIDE 1-BENZYL-3,3-DIFLUORO-PYRROLIDINE-2,5-DIONE (2S)-Fmoc-4,4-difluoro-pyrrolidine-2-carboxylic acid TETRAFLUOROSUCCINIMIDE 1-BENZYL-3,3-DIFLUORO-PYRROLIDINE BOC-D-PRO(4,4-DIFLUORO) (8aS)-7,7-difluorooctahydropyrrolo[1,2-a]pyrazine tert-butyl (2S)-2-cyano-4,4-difluoropyrrolidine-1-carboxylate

3,3-<WBR>Difluoropyrrolidine hydrochloride

3,3-Difluoropyrrolidine hydrochloride 97%

GOSO-005

cis-1-Methyl-2-oxo-1,2-dihydro-quinoline-5-carboxylic acid

3,3-DIFLUOROPYRROLIDINE HCL

3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE

Pyrrolidine, 3,3-difluoro-, hydrochloride (1:1)

1-Aza-3,3-difluorocyclopentane

3,3-Difluoropyrrolidine h...

3,3-DifluoropyrrolidineHydrochloride&gt

3,3-DifL

idine hydrochL

uoropyrroL

3,3-difluoro-Pyrrolidine hydrochloride (1:1)

3,3-Difl uoropyrrol [dine hydrochloride

163457-23-6

C4H7F2NClH

C4H8ClF2N

C4H7F2N.HCl

C5H7F2NHCl

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