N-BOC-4,4-difluoro-L-proline

Product Name: N-BOC-4,4-difluoro-L-proline
CAS No.: 203866-15-3
Chemical Name: N-BOC-4,4-difluoro-L-proline
Synonyms: EOS-60318;)-4,4-difL;BOC-L-PRO(4,4-DIFLUORO);Boc-4,4-difluoro-L-Pro-OH;BOC-4,4-DIFLUORO-L-PROLINE;(S)-1-(tert-ButoxycarbonyL;(S)-1-Boc-4,4-difluoropyr...;N-BOC-4,4-DIFLUORO-L-PROLINE;4,4-Difluoro-1-Boc-L-proline;N-T-BOC-4,4-DIFLUORO-L-PROLINE
CBNumber: CB1767047
Molecular Formula: C10H15F2NO4
Formula Weight: 251.23
MOL File: 203866-15-3.mol

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N-BOC-4,4-difluoro-L-proline Property

Melting point:: 120-124 °C
Boiling point:: 340.4±42.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 3.06±0.40(Predicted)
form: powder to crystal
color: White to Light yellow to Light orange
optical activity: [α]22/D -69.0° in chloroform
InChI: InChI=1S/C10H15F2NO4/c1-9(2,3)17-8(16)13-5-10(11,12)4-6(13)7(14)15/h6H,4-5H2,1-3H3,(H,14,15)/t6-/m0/s1
InChIKey: WTMZYKCXBXPVPT-LURJTMIESA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(F)(F)C[C@H]1C(O)=O
CAS DataBase Reference: 203866-15-3

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 687340
Product name: N-Boc-4,4-difluoro-L-proline
Purity: 97%
Packaging: 500mg
Price: $78.5
Updated: 2025/07/31

TCI Chemical

Product number: B4202
Product name: (S)-1-(tert-Butoxycarbonyl)-4,4-difluoro-2-pyrrolidinecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $322
Updated: 2024/03/01

TCI Chemical

Product number: B4202
Product name: (S)-1-(tert-Butoxycarbonyl)-4,4-difluoro-2-pyrrolidinecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 200mg
Price: $81
Updated: 2024/03/01

TRC

Product number: B648000
Product name: N-Boc-4,4-Difluoro-L-proline
Packaging: 50mg
Price: $120
Updated: 2021/12/16

TRC

Product number: B648000
Product name: N-Boc-4,4-Difluoro-L-proline
Packaging: 250mg
Price: $265
Updated: 2021/12/16

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N-BOC-4,4-difluoro-L-proline Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

N-Boc-4,4-difluoro-L-proline is a reagent used in the preparation of structure-activity relationship and pharmacokinetics of pyrrolotriazines as pan-Aurora kinase inhibitors and anti tumor agents.

Synthesis

203866-17-5

203866-15-3

The general procedure for the synthesis of N-Boc-4,4-difluoro-L-proline from N-Boc-4,4-difluoro-L-proline methyl ester was as follows: 1. 1.08 g (4.08 mmol) of tert-butyl (S)-2-methyl-4-pyrrolidine-1,4-difluoropyrrolidine-2-carboxylate (purchased from Aldrich, Catalog No. 702463) was dissolved in a mixed solvent of 10 mL of methanol and 10 mL of tetrahydrofuran. 2. 6.12 mL of 2 M aqueous sodium hydroxide was added to the above solution. 3. The reaction mixture was stirred at room temperature for 1 hour. 4. Upon completion of the reaction, the organic solvent was removed under reduced pressure. 5. The remaining aqueous phase was diluted with an appropriate amount of water and then acidified by adding 6.12 mL of 2 M hydrochloric acid. 6. After acidification, the product was extracted with dichloromethane (3 times) and the organic layers were combined. 7. The organic layer was washed with brine, dried with anhydrous magnesium sulfate, filtered and the solvent was removed under reduced pressure. 8. 1.01 g (99% yield) of N-Boc-4,4-difluoro-L-proline was finally obtained as a white solid.LRMS (m/z): 250 (M-1)+.

References

[1] Patent: WO2012/146666, 2012, A1. Location in patent: Page/Page column 138-139
[2] Tetrahedron Letters, 1998, vol. 39, # 10, p. 1169 - 1172
[3] Patent: WO2014/19344, 2014, A1. Location in patent: Paragraph 00451
[4] Patent: WO2014/82380, 2014, A1. Location in patent: Paragraph 00427; 00430
[5] Patent: WO2014/82379, 2014, A1. Location in patent: Page/Page column 158; 159; 161

N-BOC-4,4-difluoro-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-4,4-difluoro-L-proline Suppliers

Americas 1 Canada 1 China 149 Europe 1 Germany 3 India 5 Japan 1 Switzerland 1 United Kingdom 2 United States 16 Global 180

BTC Pharmaceutical CO. Ltd

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View Lastest Price from N-BOC-4,4-difluoro-L-proline manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-t-BOC-4,4-Difluoro-L-Proline 203866-15-3
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

Career Henan Chemical Co

Product: N-BOC-4,4-difluoro-L-proline 203866-15-3
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

203866-15-3, N-BOC-4,4-difluoro-L-prolineRelated Search:

L-Proline Polyvinylpyrrolidone cis-4-Hydroxy-L-proline BOC-L-Proline tert-Butyl carbazate L-PROLINE-(4-3H(N)) N-Vinyl-2-pyrrolidone D-Proline Povidone iodine N-Methyl-2-pyrrolidone 1-BOC-3,3-DIFLUOROPYRROLIDINE 2-(2,2-DIFLUORO-PROPYLAMINO)-ETHANOL 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate (2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid N-BOC-cis-4-fluoro-L-proline 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE N-trans-BOC-(3S)-Fluoropyrrolidine L-Proline, 4,4-difluoro- (9CI)

BOC-4,4-DIFLUORO-L-PROLINE

BOC-L-PRO(4,4-DIFLUORO)

(2S)-Boc-4,4-difluoro-pyrrolidine-2-carboxylic acid

(S)-1-(tert-Butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid

N-BOC-4,4-DIFLUORO-L-PROLINE

N-T-BOC-4,4-DIFLUORO-L-PROLINE

N-Boc-4,4-difluoro-L-proline, 97+%

(S)-1-Boc-4,4-difluoropyrrolidine-2-carboxylic acid

Boc-4,4-difluoro-L-Pro-OH

(S)-1-Boc-4,4-difluoropyr...

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(S)-1-(tert-Butoxycarbonyl)-4,4-difluoro-2-pyrrolidinecarboxylic Acid

(2S)-4,4-difluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

4,4-Difluoro-1-Boc-L-proline

<I>N</I>-Boc-4,4-difluoro-<SC>L</SC>-proline

N-Boc-4,4-difluoro-L-proline 97%

EOS-60318

(2S)-N-Boc-4,4-difluoro-L-proline

1-(tert-butoxycarbonyl)-4,4-difluoro-L-proline

(S)-1-(tert-Butoxycarbonyl)-4,4-difluoro-2-pyrrolidinecarboxylic Acid &gt

(S)-1-(tert-ButoxycarbonyL

)-4,4-difL

(2S)-4,4-difluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylicaci

(S)-1-Boc-4,4-difluoro-2-pyrrolidinecarboxylic Acid

N-(tert-Butoxycarbonyl)-4,4-difluoro-L-proline

N-BOC-4,4-difluoro-L-proline USP/EP/BP

1-(1,1-Dimethylethyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate

1-(tert-Butyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate

203866-15-3

C10H15F2NO4

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