N-trans-BOC-(3S)-Fluoropyrrolidine

Product Name: N-trans-BOC-(3S)-Fluoropyrrolidine
CAS No.: 479253-00-4
Chemical Name: N-trans-BOC-(3S)-Fluoropyrrolidine
Synonyms: 1-BOC-3-FLUORO PYRROLIDINE;(S)-N-BOC-3-FLUOROPYRROLIDINE;(S)-1-BOC-3-FLUORO PYRROLIDINE;N-T-BOC-(3S)-FLUOROPYRROLIDINE;TRANS-BOC-(3S)-FLUOROPYRROLIDINE;N-trans-BOC-(3S)-Fluoropyrrolidine;(S)-1-Boc-3-fluoropyrrolidine;(S)-(+)-1-Boc-3-fluoropyrrolidine,96%;(3S)-3-Fluoropyrrolidine, N-BOC protected;tert-butyl (S)-3-fluoropyrrolidine-1-carboxylate
CBNumber: CB3199398
Molecular Formula: C9H16FNO2
Formula Weight: 189.23
MOL File: 479253-00-4.mol

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N-trans-BOC-(3S)-Fluoropyrrolidine Property

Boiling point:: 74-80℃/2mm
Density: 1.069 g/mL at 25 °C
Flash point:: 103°(217°F)
refractive index: 1.4410
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Liquid
pka: -3.60±0.40(Predicted)
color: Colorless to pale yellow
Sensitive: Moisture Sensitive

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Safety

Hazard Codes: T,N
Risk Statements: 25-36-50
Safety Statements: 26-45-61
RIDADR: UN 2810 6.1 / PGIII
WGK Germany: 3
HazardClass: 6.1
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC1252
Product name: (3S)-3-Fluoropyrrolidine,N-BOCprotected
Purity: 97%
Packaging: 250mg
Price: $52
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-3-X2
Product name: N-Boc-(3S)-Fluoropyrrolidine
Purity: 97%
Packaging: 250mg
Price: $84
Updated: 2021/12/16

Activate Scientific

Product number: AS3734
Product name: (S)-N-Boc-3-fluoropyrrolidine
Purity: 95+% ee
Packaging: 1g
Price: $262
Updated: 2021/12/16

AK Scientific

Product number: 6572AB
Product name: (S)-1-Boc-3-Fluoropyrrolidine
Packaging: 1g
Price: $266
Updated: 2021/12/16

Matrix Scientific

Product number: 092516
Product name: (S)-1-Boc-3-Fluoropyrrolidine
Purity: 95+%
Packaging: 250mg
Price: $416
Updated: 2021/12/16

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N-trans-BOC-(3S)-Fluoropyrrolidine Chemical Properties,Usage,Production

Synthesis

83220-73-9

479253-00-4

1. Fluorination: To a solution of tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate (2.62 g) in dichloromethane (50 mL) was slowly added diethylaminosulfur trifluoride (2.22 mL) at -78°C. The mixture was gradually brought to room temperature and stirred for 75 minutes. The reaction mixture was gradually brought to room temperature and stirred for 75 minutes. 2. Post-treatment: The reaction mixture was poured into ice water and the organic layer was separated. The organic layer was dried with anhydrous magnesium sulfate and filtered to remove the desiccant. 3. Purification: The solvent was removed by evaporation under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate gradient) to afford tert-butyl (3S)-3-fluoropyrrolidine-1-carboxylate (676 mg, 26% yield) as an oily product. 4. 4. Product characterization: 1H-NMR (400 MHz, CDCl3) δ: 1.45 (9H, s), 2.17-2.26 (1H, m), 3.52-3.68 (5H, m), 5.20 (1H, dt, J = 52.7, 3.4 Hz).

References

[1] Patent: EP1785418, 2007, A1. Location in patent: Page/Page column 44
[2] Patent: WO2006/19833, 2006, A1. Location in patent: Page/Page column 62-63
[3] Patent: WO2006/40625, 2006, A1. Location in patent: Page/Page column 47-48
[4] Patent: WO2004/69256, 2004, A1. Location in patent: Page/Page column 48

N-trans-BOC-(3S)-Fluoropyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-trans-BOC-(3S)-Fluoropyrrolidine Suppliers

Canada 2 China 42 Germany 2 India 1 United Kingdom 1 United States 17 Global 65

Pure Chemistry Scientific Inc.

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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
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Sigma-Aldrich

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479253-00-4, N-trans-BOC-(3S)-FluoropyrrolidineRelated Search:

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N-trans-BOC-(3S)-Fluoropyrrolidine

N-T-BOC-(3S)-FLUOROPYRROLIDINE

TRANS-BOC-(3S)-FLUOROPYRROLIDINE

(S)-N-BOC-3-FLUOROPYRROLIDINE

(S)-1-BOC-3-FLUORO PYRROLIDINE

1-BOC-3-FLUORO PYRROLIDINE

tert-butyl (S)-3-fluoropyrrolidine-1-carboxylate

(3S)-3-fluoro-1-Pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

1-Pyrrolidinecarboxylicacid, 3-fluoro-, 1,1-dimethylethyl ester, (3S)-

(3S)-3-Fluoropyrrolidine, N-BOC protected

tert-Butyl (3S)-3-fluoropyrrolidine-1-carboxylate

(S)-(+)-1-Boc-3-fluoropyrrolidine,96%

(<i>S</i>)-1-Boc-3-fluoropyrrolidine

479253-00-4

C9H16FNO2

Pyrrole&Pyrrolidine&Pyrroline