1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine

Product Name: 1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine
CAS No.: 426844-76-0
Chemical Name: 1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine
Synonyms: (2S,4S)-tert-Butyl 2-cyano-4-fluoropyrrolidine-1-carboxylate;1-BOC-2-CYANO-4-FLUOROPYRROLIDINE;N-Boc-cis-4-fluoro-L-prolinonitrile;N-t-Boc-cis-4-Fluoro-L-prolinonitrile;(2S,4S)-1-Boc-2-cyano-4-fluoropyrrolidine;1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine;(2S,4S)-N-Boc-4-Fluoropyrrolidine-2-carbonitrile;-tert-Butyl 2-cyano-4-fluoropyrrolidine-1-carboxylate;(2S,4S)-1-tert-Butoxycarbonyl-2-cyano-4-fluoropyrrolidine;(2S,4S)-2-cyano-4-fluoropyrrolidine-1- tert-butyl carboxylate
CBNumber: CB51569622
Molecular Formula: C10H15FN2O2
Formula Weight: 214.24
MOL File: 426844-76-0.mol

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1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine Property

Melting point:: 88-91°C
Boiling point:: 316.7±42.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -7.30±0.60(Predicted)
Appearance: White to off-white Solid

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Safety

Risk Statements: 43
Safety Statements: 36/37
RIDADR: UN3439
HazardClass: 6.1
PackingGroup: III
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: T206008
Product name: (2S,4S)-tert-Butyl2-Cyano-4-fluoropyrrolidine-1-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: T206008
Product name: (2S,4S)-tert-Butyl2-Cyano-4-fluoropyrrolidine-1-carboxylate
Packaging: 100mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-0039844
Product name: (2S,4S)-Tert-Butyl2-cyano-4-fluoropyrrolidine-1-carboxylate
Purity: >97.0%
Packaging: 1g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC409010
Product name: N-t-BOC-cis-4-Fluoro-L-Prolinonitrile
Packaging: 250mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-3-0N
Product name: N-Boc-cis-4-fluoro-L-prolinonitrile
Packaging: 250mg
Price: $120
Updated: 2021/12/16

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1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine Chemical Properties,Usage,Production

Synthesis

426844-22-6

426844-76-0

Step 2: Synthesis of (2S,4S)-1-Boc-2-cyano-4-fluoropyrrolidine To a stirred and cooled to 0 °C solution of (2S,4S)-N-Boc-4-fluoropyrrolidine-2-carboxamide (10 g, 43.10 mmol) in anhydrous THF (50 ml) was sequentially added triethylamine (13.93 g, 138 mmol) and trifluoroacetic anhydride (14.5 g, 69.05 mmol). The reaction mixture was continued to be stirred at 0°C for 1 hour. After completion of the reaction, the reaction was quenched with 100 ml of water and extracted with chloroform (2 x 100 ml). The organic phases were combined, washed sequentially with water (2 x 100 ml) and brine (50 ml) and dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure to give 9.0 g of off-white solid product in 97.6% yield. IR (KBr, cm-1): 2979, 2243, 1387, 1240, 1168, 1123, 1072, 960. 1H NMR (CDCl3, 300MHz) δ: 1.49-1.53(d, rotary isomer, 9H), 2.25-2.47(m, 1H), 2.64(t, J=14.7Hz, 1H), 3.52(dd, J=9.6,3.6Hz, 0.5H, rotary isomer), 3.64(dd, J=9.3,3.3Hz , 0.5H, rotary isomer), 3.73-3.94 (m, 1H), 4.64 (dd, J=8.7 Hz, 0.6H, rotary isomer), 4.76 (dd, J=8.7 Hz, 0.4H, rotary isomer), 5.31 (brd, J=51.3 Hz, 1H).

References

[1] Chemical and Pharmaceutical Bulletin, 2008, vol. 56, # 8, p. 1110 - 1117
[2] Patent: WO2005/75426, 2005, A1. Location in patent: Page/Page column 35-36
[3] Patent: WO2006/90244, 2006, A1. Location in patent: Page/Page column 29
[4] Patent: WO2006/40625, 2006, A1. Location in patent: Page/Page column 44
[5] Patent: WO2007/99385, 2007, A1. Location in patent: Page/Page column 26

1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine Suppliers

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View Lastest Price from 1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine 426844-76-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Career Henan Chemical Co

Product: 1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine 426844-76-0
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-17

426844-76-0, 1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidineRelated Search:

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1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine

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(2S,4S)-2-cyano-4-fluoropyrrolidine-1- tert-butyl carboxylate

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(2S,4S)-tert-Butyl 2-cyano-4-fluoropyrrolidine-1-carboxylate

-tert-Butyl 2-cyano-4-fluoropyrrolidine-1-carboxylate

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(2S,4S)-N-Boc-4-Fluoropyrrolidine-2-carbonitrile

426844-76-0

C10H15FN2O2