N-Boc-4,4-difluoro-L-proline methyl ester

Product Name: N-Boc-4,4-difluoro-L-proline methyl ester
CAS No.: 203866-17-5
Chemical Name: N-Boc-4,4-difluoro-L-proline methyl ester
Synonyms: N-Boc-4,4-Difluoro-L<;BOC-L-PRO(4,4-DIFLUORO)-OME;Methyl (S)-1-Boc-4,4-difl...;BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER;N-Boc-4,4-difluoro-L-proline methyl ester;N-T-BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER;N-Boc-4,4-Difluoro-L-proline Methyl ester 97%;(2S)-N-Boc-4,4-difluoro-L-proline methyl ester;N-Boc-4,4-difluoro-L-proline Methyl Ester,99%e.e.;BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER USP/EP/BP
CBNumber: CB2324050
Molecular Formula: C11H17F2NO4
Formula Weight: 265.25
MOL File: 203866-17-5.mol

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N-Boc-4,4-difluoro-L-proline methyl ester Property

Melting point:: 41-46 °C
Boiling point:: 293℃
Density: 1.22
Flash point:: 110 °C
storage temp.: 2-8°C
pka: -8.00±0.60(Predicted)
form: White to off-white crystalline powder
Appearance: White to light yellow Solid
InChI: InChI=1S/C11H17F2NO4/c1-10(2,3)18-9(16)14-6-11(12,13)5-7(14)8(15)17-4/h7H,5-6H2,1-4H3/t7-/m0/s1
InChIKey: RQDZKOOUQIDZOG-ZETCQYMHSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(F)(F)C[C@H]1C(OC)=O

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Safety

WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 702463
Product name: N-Boc-4,4-Difluoro-L-proline methyl ester
Purity: 97%
Packaging: 1g
Price: $324.8
Updated: 2025/07/31

TRC

Product number: T135533
Product name: (S)-1-Tert-Butyl2-Methyl4,4-Difluoropyrrolidine-1,2-dicarboxylate
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Chem-Impex

Product number: 16539
Product name: Boc-4,4-Difluoro-L-prolinemethylester,≥99%(NMR)
Purity: ≥99%(NMR)
Packaging: 250MG
Price: $108.56
Updated: 2021/12/16

Apolloscientific

Product number: PC409002
Product name: N-t-BOC-4,4-Difluoro-L-ProlineMethylEster
Packaging: 250mg
Price: $116
Updated: 2021/12/16

AK Scientific

Product number: W4297
Product name: (S)-1-tert-Butyl2-methyl4,4-difluoropyrrolidine-1,2-dicarboxylate
Packaging: 1g
Price: $117
Updated: 2021/12/16

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N-Boc-4,4-difluoro-L-proline methyl ester Chemical Properties,Usage,Production

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

102195-80-2

203866-17-5

General procedure for the synthesis of N-BOC-4,4-difluoro-L-proline methyl ester from BOC-4-oxo-L-proline methyl ester: Intermediate 5a (300 g, 1.23 mmol, 1.00 eq.) was dissolved in dichloromethane (30 mL) at 0 °C, and DAST (1.80 g, 11.2 mmol, 9.00 eq.) was slowly added dropwise to the dichloromethane (10 mL) solution. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the reaction mixture was washed sequentially with saturated aqueous sodium bicarbonate solution (1 x 30 mL) and brine (3 x 30 mL). The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give Intermediate 5b (300 mg, 92% yield) as a yellow oil.

References

[1] Patent: WO2006/123257, 2006, A2. Location in patent: Page/Page column 70
[2] Patent: WO2013/96771, 2013, A1. Location in patent: Page/Page column 95
[3] Journal of the American Chemical Society, 2016, vol. 138, # 7, p. 2443 - 2453
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 17, p. 7589 - 7613
[5] Patent: WO2005/23762, 2005, A1. Location in patent: Page/Page column 72

N-Boc-4,4-difluoro-L-proline methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-4,4-difluoro-L-proline methyl ester Suppliers

Canada 1 China 122 Germany 1 India 3 Switzerland 1 United Kingdom 1 United States 13 Global 142

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203866-17-5, N-Boc-4,4-difluoro-L-proline methyl esterRelated Search:

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N-Boc-4,4-Difluoro-L-proline Methyl ester 97%

Methyl (S)-1-Boc-4,4-difl...

1,2-Pyrrolidinedicarboxylicacid, 4,4-difluoro-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)-

Methyl 1-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-(2S)-carboxylate

1-tert-Butyl 2-methyl (S)-4,4-difluoropyrrolidine-1,2-dicarboxylate

Methyl (S)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate

1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate

N-Boc-4,4-Difluoro-<SC>L</SC>-proline methyl ester

N-Boc-4,4-difluoro-L-proline Methyl Ester,99%e.e.

BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER

BOC-L-PRO(4,4-DIFLUORO)-OME

N-T-BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER

N-Boc-4,4-difluoro-L-proline methyl ester

1-tert-Butyl 2-methyl (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate, tert-Butyl (2S)-2-(methoxycarbonyl)-4,4-difluoropyrrolidine-1-carboxylate

1-tert-Butyl 2-methyl (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate

tert-Butyl (2S)-2-(methoxycarbonyl)-4,4-difluoropyrrolidine-1-carboxylate

(S)-4,4-Difluoro-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester

O1-tert-butyl O2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate

1-tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate

1-O-tert-butyl 2-O-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate

1-(tert-butyl) 2-methyl (S)-4,4-difluoropyrrolidine-1,2-dica

BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER USP/EP/BP

(2S)-N-Boc-4,4-difluoro-L-proline methyl ester

N-Boc-4,4-Difluoro-<SC>L<

<i>N</i>-Boc-4,4-Difluoro-<sc>L</sc>-proline methyl ester

203866-17-5

C11H17F2NO4