BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER

Product Name: BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER
CAS No.: 203866-18-6
Chemical Name: BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER
Synonyms: BOC-trans-4-Fluoroproline methyl ester;BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER;(4R)-1-BOC-4-FLUORO-L-PROLINE METHYL ESTER;N-Boc-tran-4-Fluoro-L-proline Methyl ester;1-Boc-Trans-4-fluoro-L-proline Methyl ester;N-Boc-trans-4-fluoro-L-proline methyl ester;N-T-BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER;N-Boc-trans-4-fluoro-L-proline methyl ester 97%;(2S,4R)-N-Boc-trans-4-fluoro-L-proline methyl ester;BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER USP/EP/BP
CBNumber: CB9314591
Molecular Formula: C11H18FNO4
Formula Weight: 247.26
MOL File: 203866-18-6.mol

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BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER Property

Melting point:: 34-39 °C
Density: 1.16
Flash point:: 110 °C
storage temp.: 2-8°C
form: powder
Appearance: Colorless to off-white <36°C Solid,>39°C Liquid
optical activity: [α]22/D -80.0°, c = 1 in methanol
Water Solubility: Insoluble in water.
InChI: InChI=1S/C11H18FNO4/c1-11(2,3)17-10(15)13-6-7(12)5-8(13)9(14)16-4/h7-8H,5-6H2,1-4H3/t7-,8+/m1/s1
InChIKey: METPQQHVRNLTRX-SFYZADRCSA-N
SMILES: N1(C(OC(C)(C)C)=O)C[C@H](F)C[C@H]1C(OC)=O

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Safety

WGK Germany: 3
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 702412
Product name: N-Boc-trans-4-fluoro-L-proline methyl ester
Purity: 97%
Packaging: 1g
Price: $436
Updated: 2025/07/31

Sigma-Aldrich

Product number: 702412
Product name: N-Boc-trans-4-fluoro-L-proline methyl ester
Purity: 97%
Packaging: 250mg
Price: $200
Updated: 2023/06/20

TRC

Product number: B663438
Product name: N-Boc-trans-4-fluoro-L-proline methyl ester
Packaging: 250mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50550
Product name: Boc-trans-4-fluoro-L-proline methyl ester
Packaging: 5G
Price: $62.5
Updated: 2021/12/16

Chem-Impex

Product number: 16540
Product name: Boc-trans-4-fluoro-L-prolinemethylester,98.5%(HPLC)
Purity: 98.5%(HPLC)
Packaging: 1G
Price: $26.6
Updated: 2021/12/16

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BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER Chemical Properties,Usage,Production

Uses

N-Boc-trans-4-fluoro-L-proline methyl ester is used to prepare (S)-2-[N-(N'-benzyl-(S)-4-fluoro-L-prolyl)amino]benzophenone by reacting with of 2-aminobenzophenone in the presence of potassium tert -butoxide.

Synthesis

203866-14-2

74-88-4

203866-18-6

GENERAL STEPS: (2S,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid (2 g, 8.57 mmol), potassium carbonate (5.9 g, 42.69 mmol), and THF (80 mL) were mixed, and methyl iodide (6.1 g, 42.98 mmol) was added, and the reaction was stirred for 12 hours at room temperature. After completion of the reaction, the solid was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by rapid chromatography on silica gel with EtOAc/petroleum ether (1:5) as eluent to afford N-BOC-trans-4-fluoro-L-proline methyl ester (800 mg, 38% yield) as a colorless oil.

References

[1] Patent: WO2015/52264, 2015, A1. Location in patent: Paragraph 0521; 0522; 01714; 01715

BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER Suppliers

Canada 1 China 111 India 1 Switzerland 2 United Kingdom 4 United States 17 Global 136

Shanghai Xinxin Pharmaceutical Technology Co., Ltd.

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Shanghai Jian Chao Chemical Technology Co., Ltd.

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View Lastest Price from BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER manufacturers

Career Henan Chemical Co

Product: BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER 203866-18-6
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

203866-18-6, BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTERRelated Search:

(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypiperidine-2-carboxylic acid BOC-TRANS-4-FLUORO-5-OXO-L-PROLINE METHYL ESTER (2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate METHYL (2S,4R)-4-FLUOROPROLINATE BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER N-Boc-cis-4-Hydroxy-L-proline methyl ester (S)-Methyl-2-Boc-AMino-4-pentenoic acid (2R,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid N-BOC-SERINOL, 97 N-Boc-trans-4-amino-L-proline methyl ester hydrochloride N-Boc-Trans-4-Hydroxy-D-proline methyl ester N-BOC-CYCLOHEXAMIDE N-Boc-N-methyl-(S)-2-allylglycine N-BOC-AMino-(4-N-BOC-piperidinyl)carboxylic acid N-Boc-trans-4-amino-L-proline methyl ester (S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER

METHYL N-(TERT-BUTOXYCARBONYL)-(2S, 4R)-4-FLUOROPROLINATE

N-T-BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER

(4R)-1-BOC-4-FLUORO-L-PROLINE METHYL ESTER

(2S,4R)-4-fluoropyrrolidine-1,2-dicarboxylic acid O1-tert-butyl ester O2-methyl ester

(2S,4R)-N-Boc-trans-4-fluoro-L-proline methyl ester

N-Boc-trans-4-fluoro-L-proline methyl ester

1-tert-Butyl 2-methyl (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

(2S,4R)-4-Fluoro-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester

(2S,4R)-1-tert-Butyl 2-Methyl 4-fluoropyrrolidine-1,2-dicarboxylate

1-Boc-Trans-4-fluoro-L-proline Methyl ester

N-Boc-tran-4-Fluoro-L-proline Methyl ester

1-tert-butyl 2-methyl (2S,4R)-4-fluoropyrrolidine-1,2-dicarboxylate

Methyl (2S,4R)-1-Boc-4-fluoropyrrolidine-2-carboxylate

N-Boc-trans-4-fluoro-L-proline methyl ester 97%

1-O-tert-butyl 2-O-methyl (2S,4R)-4-fluoropyrrolidine-1,2-dicarboxylate

-1-tert-Butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate

(2S,4R)-4-Fluoro-tert-butyl-1,2-pyrrolidinedicarboxylic A cid 2-Methyl Ester,99%e.e.

(2S,4R)-4-Fluoro-tert-butyl-1,2-pyrrolidinedicarboxylic Acid 2-Methyl Ester

1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-

BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER USP/EP/BP

BOC-trans-4-Fluoroproline methyl ester

1-(1,1-Dimethylethyl) 2-methyl (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

<i>N</i>-Boc-<i>trans</i>-4-fluoro-<sc>L</sc>-proline methyl ester

Methyl (2S,4R)-1-Boc-4-fluoropyrrolidine-2-carboxylate - [E13524]

203866-18-6

C11H18FNO4

Asymmetric Synthesis

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Chemical Synthesis

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