1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

Product Name: 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
CAS No.: 203866-14-2
Chemical Name: 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
Synonyms: N-BOC-TRANS-4-FLUORO-L-PROLINE;N-BOC-(4S,2R)-4-FLUORO-2-PYRROLIDINECARBOXYLIC ACID;Boc-trans-4-F-Pro-OH;Boc-trans-4-fluoro-Pro-OH;BOC-TRANS-4-FLUORO-L-PROLINE;N-Boc-Tran-4-Fluoro-L-proline;1-BOC-Trans-4-fluoro-L-proline;(2R,4S)-N-BOC-4-FLUORO-D-PROLINE;N-T-BOC-TRANS-4-FLUORO-L-PROLINE;(2S,4R)-N-Boc-trans-4-Fluoro-L-Proline
CBNumber: CB2312240
Molecular Formula: C10H16FNO4
Formula Weight: 233.24
MOL File: 203866-14-2.mol

More

Less

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Property

Melting point:: 115-119°C
Boiling point:: 346.0±42.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
refractive index: -69 ° (C=1, MeOH)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 3.53±0.40(Predicted)
color: White to Almost white
optical activity: [α]22/D -65.0±5°, c = 1 in chloroform
InChI: InChI=1S/C10H16FNO4/c1-10(2,3)16-9(15)12-5-6(11)4-7(12)8(13)14/h6-7H,4-5H2,1-3H3,(H,13,14)/t6-,7+/m1/s1
InChIKey: YGWZXQOYEBWUTH-RQJHMYQMSA-N
SMILES: N1(C(OC(C)(C)C)=O)C[C@H](F)C[C@H]1C(O)=O
CAS DataBase Reference: 203866-14-2(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 687332
Product name: N-Boc-trans-4-fluoro-L-proline
Purity: 97%
Packaging: 500mg
Price: $151.2
Updated: 2025/07/31

TCI Chemical

Product number: B3177
Product name: (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid
Purity: >96.0%(GC)(T)
Packaging: 1g
Price: $193
Updated: 2025/07/31

TCI Chemical

Product number: B3177
Product name: (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid
Purity: >96.0%(GC)(T)
Packaging: 200mg
Price: $58
Updated: 2025/07/31

Usbiological

Product number: 458406
Product name: N-Boc-trans-4-fluoro-L-proline
Packaging: 500mg
Price: $347
Updated: 2021/12/16

Chem-Impex

Product number: 16537
Product name: Boc-trans-4-fluoro-L-proline,≥97%(HPLC)
Purity: ≥97%(HPLC)
Packaging: 1G
Price: $23.3
Updated: 2021/12/16

More

Less

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-trans-4-fluoro-L-proline is a useful synthetic intermediate. It is used to prepare potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors. It is also used to synthesize pyrrolotriazines derivatives as pan-Aurora kinase inhibitors and anti-tumor agents.

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Suppliers

Americas 1 Canada 2 China 176 Europe 1 France 1 Germany 4 India 3 Japan 1 Switzerland 1 United Kingdom 5 United States 28 Global 223

Shanghai Xinxin Pharmaceutical Technology Co., Ltd.

Tel: 13671725141
Email: hickle@yeah.net
Country: China
ProdList: 769
Advantage: 58

Shanghai joygo pharmacetical tech., Co., Ltd.

Tel: 13621615409
Fax: QQ:3065286126, 1796903118
Email: sale1@joygooo.com
Country: China
ProdList: 108
Advantage: 50

Shanghai GaoLang Chemical Technology Co., Ltd.

Tel: 021-57340939 18017297327
Fax: 021-37210791
Email: sales@gaolangchemical.com
Country: China
ProdList: 892
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

More

Less

View Lastest Price from 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate manufacturers

R&D Scientific Inc.

Product: N-BOC-trans-4-fluoro-L-proline 203866-14-2
Price: US $1400.00/Kg
Min. Order: 0.100Kg
Purity: 98 %
Supply Ability: 500 Kg
Release date: 2026-01-03

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-t-BOC-trans-4-Fluoro-L-Proline 203866-14-2
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: BOC-TRANS-4-FLUORO-L-PROLINE 203866-14-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

203866-14-2, 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylateRelated Search:

Nr (2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid (2R,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid N-BOC-cis-4-fluoro-L-proline Cbz-D-Valine L-Proline D-Proline N-Boc-cis-4-Fluoro-D-Proline BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER,N-T-BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER,N-Boc-trans-4-fluoro-L-proline methyl ester N-BOC-4,4-difluoro-L-proline BOC-TRANS-4-FLUORO-5-OXO-L-PROLINE METHYL ESTER 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

N-BOC-(4S,2R)-4-FLUORO-2-PYRROLIDINECARBOXYLIC ACID

N-BOC-TRANS-4-FLUORO-L-PROLINE

N-T-BOC-TRANS-4-FLUORO-L-PROLINE

N-(TERT-BUTOXYCARBONYL)-(2S,4R)-4-FLUOROPROLINE

BOC-TRANS-4-FLUORO-L-PROLINE

(2S,4R)-N-Boc-trans-4-Fluoro-L-Proline

(2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid, N4-BOC protected

trans-4-Fluoro-L-proline, N-BOC protected

(2S,4R)-Boc-4-fluoro-pyrrolidine-2-carboxylic acid

(2R,4S)-N-BOC-4-FLUORO-D-PROLINE

(2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid, N-BOC protected

(2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid

(2S,4R)-1-Boc-4-fluoro-2-pyrrolidinecarboxylic Acid

N-(tert-Butoxycarbonyl)-trans-4-fluoro-L-proline

(2S,4R)-4-FLUORO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

(2R,4S)-N-Boc-trans-4-Fluoro-D-proline methyl ester

(2R,4S)-N-Boc-trans-4-Fluoro-D-proline

trans-1-(tert-Butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylicacid

N-Boc-Tran-4-Fluoro-L-proline

Boc-trans-4-fluoro-Pro-OH

(2S,4R)-1-Boc-4-fluoro-2-pyrrolidinecarboxylic Acid N-(tert-Butoxycarbonyl)-trans-4-fluoro-L-proline N-Boc-trans-4-fluoro-L-proline

1-BOC-Trans-4-fluoro-L-proline

(2S,4R)-1-Boc-4-fluoropyrrolidine-2-carboxylic acid

(2S,4R)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboyxlic acid

(2S,4R)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

(2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid

(2S,4R)-4-Fluoro-1,2-pyrrolidinedicarboxylic Acid tert-B utyl Ester

1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) ester, (2S,4R)-

(2S,4R)-N-Boc-4-fluoropyrrolidine-2-carboxy lic acid

(2S,4R)-1-(tert-Dutoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid

(2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid &gt

(2S,4R)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylicaci

BOC-TRANS-4-FLUORO-L-PROLINE USP/EP/BP

TIANFU CHEM --BOC-TRANS-4-FLUORO-L-PROLINE

Boc-trans-4-F-Pro-OH

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

1-(tert-Butyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

N-Boc-trans-4-fluoro-<sc>L</sc>-proline

N-BOC-(2S,4R)-4-fluoro-2-pyrrolidinecarboxylic acid

203866-14-2

Carboxylic Acids (Chiral)

Chiral Building Blocks

Synthetic Organic Chemistry

Chiral Building Blocks

Heterocyclic Building Blocks

Pyrrolidines