ChemicalBook > CAS DataBase List > 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

Product Name
1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
CAS No.
203866-14-2
Chemical Name
1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
Synonyms
N-BOC-TRANS-4-FLUORO-L-PROLINE;N-BOC-(4S,2R)-4-FLUORO-2-PYRROLIDINECARBOXYLIC ACID;Boc-trans-4-F-Pro-OH;Boc-trans-4-fluoro-Pro-OH;BOC-TRANS-4-FLUORO-L-PROLINE;N-Boc-Tran-4-Fluoro-L-proline;1-BOC-Trans-4-fluoro-L-proline;(2R,4S)-N-BOC-4-FLUORO-D-PROLINE;N-T-BOC-TRANS-4-FLUORO-L-PROLINE;(2S,4R)-N-Boc-trans-4-Fluoro-L-Proline
CBNumber
CB2312240
Molecular Formula
C10H16FNO4
Formula Weight
233.24
MOL File
203866-14-2.mol
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1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Property

Melting point:
115-119°C
Boiling point:
346.0±42.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
refractive index 
-69 ° (C=1, MeOH)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
3.53±0.40(Predicted)
color 
White to Almost white
optical activity
[α]22/D -65.0±5°, c = 1 in chloroform
InChIKey
YGWZXQOYEBWUTH-RQJHMYQMSA-N
CAS DataBase Reference
203866-14-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
687332
Product name
N-Boc-trans-4-fluoro-L-proline
Purity
97%
Packaging
500mg
Price
$84
Updated
2024/03/01
TCI Chemical
Product number
B3177
Product name
(2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid
Purity
>96.0%(GC)(T)
Packaging
1g
Price
$198
Updated
2024/03/01
TCI Chemical
Product number
B3177
Product name
(2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid
Purity
>96.0%(GC)(T)
Packaging
200mg
Price
$59
Updated
2024/03/01
Alfa Aesar
Product number
H27721
Product name
N-Boc-trans-4-fluoro-L-proline, 98%
Packaging
250mg
Price
$71.8
Updated
2021/12/16
Alfa Aesar
Product number
H27721
Product name
N-Boc-trans-4-fluoro-L-proline, 98%
Packaging
1g
Price
$180
Updated
2021/12/16
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1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-trans-4-fluoro-L-proline is a useful synthetic intermediate. It is used to prepare potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors. It is also used to synthesize pyrrolotriazines derivatives as pan-Aurora kinase inhibitors and anti-tumor agents.

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Suppliers

Americas 1 Canada 1 China 165 Europe 1 France 1 Germany 4 India 2 Japan 1 Switzerland 1 United Kingdom 5 United States 28 Global 210
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
BOC-TRANS-4-FLUORO-L-PROLINE 203866-14-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
BOC-TRANS-4-FLUORO-L-PROLINE 203866-14-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
BOC-TRANS-4-FLUORO-L-PROLINE 203866-14-2
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2018-12-17

203866-14-2, 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylateRelated Search:

Nr (2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid (2R,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid N-BOC-cis-4-fluoro-L-proline Cbz-D-Valine L-Proline D-Proline N-Boc-cis-4-Fluoro-D-Proline BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER,N-T-BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER,N-Boc-trans-4-fluoro-L-proline methyl ester N-BOC-4,4-difluoro-L-proline BOC-TRANS-4-FLUORO-5-OXO-L-PROLINE METHYL ESTER 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

  • N-BOC-(4S,2R)-4-FLUORO-2-PYRROLIDINECARBOXYLIC ACID
  • N-BOC-TRANS-4-FLUORO-L-PROLINE
  • N-T-BOC-TRANS-4-FLUORO-L-PROLINE
  • N-(TERT-BUTOXYCARBONYL)-(2S,4R)-4-FLUOROPROLINE
  • BOC-TRANS-4-FLUORO-L-PROLINE
  • (2S,4R)-N-Boc-trans-4-Fluoro-L-Proline
  • (2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid, N4-BOC protected
  • trans-4-Fluoro-L-proline, N-BOC protected
  • (2S,4R)-Boc-4-fluoro-pyrrolidine-2-carboxylic acid
  • (2R,4S)-N-BOC-4-FLUORO-D-PROLINE
  • (2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid, N-BOC protected
  • (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid
  • (2S,4R)-1-Boc-4-fluoro-2-pyrrolidinecarboxylic Acid
  • N-(tert-Butoxycarbonyl)-trans-4-fluoro-L-proline
  • (2S,4R)-4-FLUORO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
  • (2R,4S)-N-Boc-trans-4-Fluoro-D-proline methyl ester
  • (2R,4S)-N-Boc-trans-4-Fluoro-D-proline
  • trans-1-(tert-Butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylicacid
  • N-Boc-Tran-4-Fluoro-L-proline
  • Boc-trans-4-fluoro-Pro-OH
  • (2S,4R)-1-Boc-4-fluoro-2-pyrrolidinecarboxylic Acid N-(tert-Butoxycarbonyl)-trans-4-fluoro-L-proline N-Boc-trans-4-fluoro-L-proline
  • 1-BOC-Trans-4-fluoro-L-proline
  • (2S,4R)-1-Boc-4-fluoropyrrolidine-2-carboxylic acid
  • (2S,4R)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboyxlic acid
  • (2S,4R)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
  • (2<i>S</i>,4<i>R</i>)-1-(<i>tert</i>-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid
  • (2S,4R)-4-Fluoro-1,2-pyrrolidinedicarboxylic Acid tert-B utyl Ester
  • 1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) ester, (2S,4R)-
  • (2S,4R)-N-Boc-4-fluoropyrrolidine-2-carboxy lic acid
  • (2S,4R)-1-(tert-Dutoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid
  • (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid &gt
  • (2S,4R)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylicaci
  • BOC-TRANS-4-FLUORO-L-PROLINE USP/EP/BP
  • TIANFU CHEM --BOC-TRANS-4-FLUORO-L-PROLINE
  • Boc-trans-4-F-Pro-OH
  • 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
  • 1-(tert-Butyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
  • 203866-14-2
  • Carboxylic Acids (Chiral)
  • Chiral Building Blocks
  • Synthetic Organic Chemistry
  • Chiral Building Blocks
  • Heterocyclic Building Blocks
  • Pyrrolidines