L-Proline, 4,4-difluoro- (9CI)
- Product Name
- L-Proline, 4,4-difluoro- (9CI)
- CAS No.
- 52683-81-5
- Chemical Name
- L-Proline, 4,4-difluoro- (9CI)
- Synonyms
- (S)-4,4-Difluoropyrrolidine-2-carboxylic acid;4,4-difluoroproline;4,4-difluoro-L-Proline;L-Proline, 4,4-difluoro-;L-Proline, 4,4-difluoro- (9CI);(2S)-4,4-Difluoropyrrolidine-2-carboxylic acid
- CBNumber
- CB41068562
- Molecular Formula
- C5H7F2NO2
- Formula Weight
- 151.11
- MOL File
- 52683-81-5.mol
L-Proline, 4,4-difluoro- (9CI) Property
- Boiling point:
- 254.0±40.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.40±0.40(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D456200
- Product name
- (2S)-4,4-Difluoropyrrolidine-2-carboxylicacid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- D456200
- Product name
- (2S)-4,4-Difluoropyrrolidine-2-carboxylicacid
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- D456200
- Product name
- (2S)-4,4-Difluoropyrrolidine-2-carboxylicacid
- Packaging
- 1g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 233568
- Product name
- 4,4-Difluoro-L-Proline
- Packaging
- 100mg
- Price
- $496
- Updated
- 2021/12/16
- Product number
- FD98524
- Product name
- (2S)-4,4-Difluoropyrrolidine-2-carboxylic acid
- Packaging
- 1g
- Price
- $500
- Updated
- 2021/12/16
L-Proline, 4,4-difluoro- (9CI) Chemical Properties,Usage,Production
Synthesis
203866-15-3
52683-81-5
General procedure for the synthesis of (S)-4,4-difluoropyrrolidine-2-carboxylic acid from N-Boc-4,4-difluoro-L-proline: 1. (S)-1-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid (500 mg, 1.99 mmol) was dissolved in methanol (30 mL). 2. To the above solution was added a dioxane solution (3 mL) of 4N HCl. 3. The reaction mixture was stirred at room temperature for 6 hours. 4. Upon completion of the reaction, the reaction solution was concentrated to give an oily product (480 mg, 100% yield), which could be used in the next step without further purification. 5. The structure of the product was determined by 1H NCl and the reaction was carried out in aqueous solution. 5. The structure of the product was confirmed by 1H NMR (CD3OD, 400 MHz): δ 4.76 (1H, t, J = 8.5 Hz), 3.79-3.87 (2H, m), 2.91-3.03 (1H, m), 2.73-2.82 (1H, m).
References
[1] Patent: US2008/9497, 2008, A1. Location in patent: Page/Page column 109
[2] Patent: WO2014/82379, 2014, A1. Location in patent: Page/Page column 158; 159; 163
[3] Tetrahedron Letters, 1998, vol. 39, # 10, p. 1169 - 1172
L-Proline, 4,4-difluoro- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
L-Proline, 4,4-difluoro- (9CI) Suppliers
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