3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE
- Product Name
- 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE
- CAS No.
- 163457-23-6
- Chemical Name
- 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE
- Synonyms
- 3,3-DIFLUOROPYRROLIDINE HCL;GOSO-005;3,3-DifL;uoropyrroL;idine hydrochL;3,3-Difluoropyrrolidine h...;1-Aza-3,3-difluorocyclopentane;3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE;3,3-DifluoropyrrolidineHydrochloride>3,3-Difl uoropyrrol [dine hydrochloride
- CBNumber
- CB3429107
- Molecular Formula
- C4H7F2N.ClH
- Formula Weight
- 143.56
- MOL File
- 163457-23-6.mol
3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Property
- Melting point:
- 128-130°C
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- color
- White to off white
- Sensitive
- Hygroscopic
- InChI
- InChI=1S/C4H7F2N.ClH/c5-4(6)1-2-7-3-4;/h7H,1-3H2;1H
- InChIKey
- YYVPZQADFREIFR-UHFFFAOYSA-N
- SMILES
- N1CCC(F)(F)C1.[H]Cl
- CAS DataBase Reference
- 163457-23-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, HYGROSCOPIC
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 694509
- Product name
- 3,3-Difluoropyrrolidine hydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $114
- Updated
- 2025/07/31
- Product number
- 694509
- Product name
- 3,3-Difluoropyrrolidine hydrochloride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $49.1
- Updated
- 2023/06/20
- Product number
- D4315
- Product name
- 3,3-Difluoropyrrolidine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 200mg
- Price
- $47
- Updated
- 2025/07/31
- Product number
- D4315
- Product name
- 3,3-Difluoropyrrolidine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $140
- Updated
- 2025/07/31
- Product number
- D445810
- Product name
- 3,3-Difluoropyrrolidine hydrochloride
- Packaging
- 2.5g
- Price
- $420
- Updated
- 2021/12/16
3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
Beige solid
Uses
3,3-Difluoropyrrolidine hydrochloride can be used as a building block in the synthesis of:
- Triazole substituted prolyl difluoropyrrolidines as potential inhibitors of dipeptidyl peptidase-4.
- Dual leucine zipper kinase (DLK) inhibitors.
It can be also used as a reactant in the preparation of cyclic and acyclic β-aminofluoroalkenes via allylic amination using the Pd catalyst.
Synthesis
195447-25-7
163457-23-6
Part C: 1,1-dimethylethyl 3,3-difluoropyrrolidine-1-carboxylate (0.868 g, 4.19 mmol) was dissolved in 1.5 mL of 1,4-dioxane and cooled to 0°C. A 1,4-dioxane solution (11 mL, 44 mmol) of 4 M hydrogen chloride was slowly added with stirring. The reaction mixture was continued to be stirred at 0°C for 40 minutes, then brought to room temperature and stirred for 1 hour. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to afford 0.65 g of 3,3-difluoropyrrolidine hydrochloride (100% yield). The product was characterized by 1H-NMR (CD3OD): δ 3.54 (2H, t, J = 11.9 Hz), 3.43 (2H, t, J = 7.8 Hz), 2.40 (2H, m).
References
[1] Patent: US2004/186134, 2004, A1. Location in patent: Page 241
[2] Patent: US2018/237472, 2018, A1. Location in patent: Paragraph 0170; 0171
[3] Patent: WO2017/17630, 2017, A1. Location in patent: Page/Page column 57
3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Suppliers
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View Lastest Price from 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE manufacturers
- Product
- 3,3-Difluoropyrrolidine HCl 163457-23-6
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-24
- Product
- 3,3-Difluoropyrrolidine Hydrochloride 163457-23-6
- Price
- US $0.00/G
- Min. Order
- 5G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-03
- Product
- 3,3-Difluoropyrrolidine hydrochloride 163457-23-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09