ChemicalBook > CAS DataBase List > 4,4-DIFLUOROCYCLOHEXANONE

4,4-DIFLUOROCYCLOHEXANONE

Product Name
4,4-DIFLUOROCYCLOHEXANONE
CAS No.
22515-18-0
Chemical Name
4,4-DIFLUOROCYCLOHEXANONE
Synonyms
4,4-Difluorocyclohexan-1-one;uorocycL;4,4-DIFLUOROCYCLOHEXANONE;4,4-difluro-cyclohexanone;Cyclohexanone, 4,4-difluoro-;1,1,-Difluoro-4-oxocyclohexane;4,4-Difluorocyclohexanone;4,4-Difluorocyclohexanone(WX900093);TIANFU CHEM --4,4-DIFLUOROCYCLOHEXANONE
CBNumber
CB5149175
Molecular Formula
C6H8F2O
Formula Weight
134.12
MOL File
22515-18-0.mol
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4,4-DIFLUOROCYCLOHEXANONE Property

Melting point:
35-36°C
Boiling point:
157.4±40.0 °C(Predicted)
Density 
1.14g/ml
Flash point:
65°C
storage temp. 
Sealed in dry,Store in freezer, under -20°C
form 
low melting solid
Appearance
white solid
Water Solubility 
Insoluble in water.
InChI
InChI=1S/C6H8F2O/c7-6(8)3-1-5(9)2-4-6/h1-4H2
InChIKey
NYYSPVRERVXMLJ-UHFFFAOYSA-N
SMILES
C1(=O)CCC(F)(F)CC1
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
711403
Product name
4,4-Difluorocyclohexanone
Purity
97%
Packaging
250mg
Price
$190.95
Updated
2025/07/31
TCI Chemical
Product number
D4516
Product name
4,4-Difluorocyclohexanone
Purity
min. 98.0 %
Packaging
1G
Price
$52
Updated
2025/07/31
TCI Chemical
Product number
D4516
Product name
4,4-Difluorocyclohexanone
Purity
min. 98.0 %
Packaging
5G
Price
$156
Updated
2025/07/31
TRC
Product number
D447535
Product name
4,4-Difluorocyclohexanone
Packaging
10g
Price
$970
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0036812
Product name
4,4-DIFLUOROCYCLOHEXANONE
Purity
95.00%
Packaging
5G
Price
$1129.13
Updated
2021/12/16
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4,4-DIFLUOROCYCLOHEXANONE Chemical Properties,Usage,Production

Chemical Properties

White to brown solid

Uses

4,4-Difluorocyclohexanone is used as a pharmaceutical intermediate.

Synthesis

176251-49-3

22515-18-0

4.3. Synthesis of 4,4-difluorocyclohexanone (8): the acetonide 7 (20.0 g, 112.2 mmol) was suspended in 20% HCl aqueous solution (16 mL) and stirred vigorously for 3 hours at 100 °C. After the reaction was completed, it was cooled to room temperature and NaCl (~3 g) was added to the aqueous phase to dissolve it. Subsequently, the aqueous phase was extracted with CH2Cl2 (3 x 50 mL). The organic phases were combined, washed with 50 mL of water, dried over Na2SO4, and the solvent was slowly evaporated under reduced pressure at 20 °C. Due to the extreme instability of the product, the material initially obtained was a 1:1 mixture of product 8 and raw material 5. After repeating the above operation, the ratio of 8 to 5 in the mixture was increased to 7:3. After a number of repetitions, the final product 8 was obtained with 95% purity as white crystals (11.0 g, 71% yield) with a melting point of 31-32°C. The product was then dried over 50 mL of water and evaporated slowly at 20°C under reduced pressure.

References

[1] Organic Letters, 2013, vol. 15, # 5, p. 1088 - 1091
[2] Tetrahedron, 2013, vol. 69, # 20, p. 4066 - 4075
[3] Patent: US2006/293392, 2006, A1. Location in patent: Page/Page column 51
[4] Patent: WO2008/7930, 2008, A1. Location in patent: Page/Page column 28
[5] Patent: WO2009/48547, 2009, A1. Location in patent: Page/Page column 40

4,4-DIFLUOROCYCLOHEXANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4-DIFLUOROCYCLOHEXANONE Suppliers

Belgium 1 Canada 2 China 204 Germany 3 India 5 Japan 3 United Kingdom 8 United States 23 Global 249
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View Lastest Price from 4,4-DIFLUOROCYCLOHEXANONE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4,4-DIFLUOROCYCLOHEXANONE 22515-18-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-09
Career Henan Chemical Co
Product
4,4-DIFLUOROCYCLOHEXANONE 22515-18-0
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-08-08

22515-18-0, 4,4-DIFLUOROCYCLOHEXANONERelated Search:

4,4-Difluorocyclohexanol 4,4-DIFLUOROPIPERIDINE 4,4-DIFLUOROCYCLOHEXYLAMINE HYDROCHLORIDE 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE 2,2-Difluoropropionic acid Ethyl 2,2-Difluoropropionate 4,4-Difluoropiperidine hydrochloride 4,4-DIFLUOROCYCLOHEXANONE

  • 4,4-DIFLUOROCYCLOHEXANONE
  • 4,4-Difluorocyclohexan-1-one
  • 1,1,-Difluoro-4-oxocyclohexane
  • 4,4-difluro-cyclohexanone
  • 4,4-<WBR>Difluorocyclohexanone
  • Cyclohexanone, 4,4-difluoro-
  • 4,4-Difluorocyclohexanone(WX900093)
  • uorocycL
  • TIANFU CHEM --4,4-DIFLUOROCYCLOHEXANONE
  • 22515-18-0
  • 22525-18-0
  • C6H8F2O
  • Alkyl Fluorinated Building Blocks
  • Building Blocks
  • C3 to C6
  • Carbonyl Compounds
  • Chemical Synthesis
  • Fluorinated Building Blocks
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