2,2-Difluoropropionic acid
Uses Uses- Product Name
- 2,2-Difluoropropionic acid
- CAS No.
- 373-96-6
- Chemical Name
- 2,2-Difluoropropionic acid
- Synonyms
- 2,2-Difluoropropanoic acid;2,2-DIFLUOROPROPIONIC ACID;Propanoic acid, 2,2-difluoro-;2,2-Difluoropropionic acid 97%
- CBNumber
- CB1301258
- Molecular Formula
- C3H4F2O2
- Formula Weight
- 110.06
- MOL File
- 373-96-6.mol
2,2-Difluoropropionic acid Property
- Melting point:
- 38-45 °C
- Boiling point:
- 25-30 °C/5 mmHg
- Density
- 1.316±0.06 g/cm3(Predicted)
- Flash point:
- 25-30°C/5mm
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 1.34±0.10(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C3H4F2O2/c1-3(4,5)2(6)7/h1H3,(H,6,7)
- InChIKey
- PMWGIVRHUIAIII-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C(F)(F)C
- CAS DataBase Reference
- 373-96-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 34-36
- Safety Statements
- 26-36/37/39
- RIDADR
- 3261
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29159000
N-Bromosuccinimide Price
- Product number
- 684686
- Product name
- 2,2-Difluoropropionic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $578.55
- Updated
- 2025/07/31
- Product number
- D5531
- Product name
- 2,2-Difluoropropionic Acid
- Packaging
- 1G
- Price
- $50
- Updated
- 2025/07/31
- Product number
- D455898
- Product name
- 2,2-Difluoropropionic Acid
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- D455898
- Product name
- 2,2-Difluoropropionic Acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- D455898
- Product name
- 2,2-Difluoropropionic Acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
2,2-Difluoropropionic acid Chemical Properties,Usage,Production
Uses
2,2-Difluoropropionic acid is a useful research chemical.
Uses
2,2-Difluoropropionic acid is mainly used in biochemical research.
Chemical Properties
White powder
Synthesis
28781-85-3
373-96-6
The general procedure for synthesizing 2,2-difluoropropionic acid from ethyl 2,2-difluoropropionate was as follows: referring to Example G38, ethyl 2,2-difluoropropionate (1.2 g, 8.8 mmol) was dissolved in ethanol (26 mL), followed by the slow addition of 2N aqueous sodium hydroxide solution (26 mL). The reaction mixture was stirred at 0 °C, then gradually warmed to room temperature and continued stirring for 14 hours. Upon completion of the reaction, the reaction mixture was acidified to pH < 7 with 2N hydrochloric acid and then extracted with ether. The organic phases were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 2,2-difluoropropionic acid (0.90 g, 92% yield). The product was an oil with the following 1H-NMR (CDCl3) data: δ 1.85 (3H, t, J = 19.0 Hz), 6.21 (1H, br s).
References
[1] Patent: EP1402900, 2004, A1
[2] Patent: US2004/53973, 2004, A1
[3] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, p. 1260 - 1263
[4] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 7, p. 1417 - 1420
[5] Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 1597 - 1601
2,2-Difluoropropionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,2-Difluoropropionic acid manufacturers
- Product
- 2,2-Difluoropropionic acid 373-96-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-22
- Product
- 2,2-Difluoropropionic acid 373-96-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2025-04-01
- Product
- 2,2-Difluoropropionic acid 373-96-6
- Price
- US $0.00/kg
- Min. Order
- 100g
- Purity
- 97%
- Supply Ability
- 100kg
- Release date
- 2019-02-13