Uses Application
ChemicalBook > CAS DataBase List > 2,2-Difluoropropionic acid

2,2-Difluoropropionic acid

Uses Application
Product Name
2,2-Difluoropropionic acid
CAS No.
373-96-6
Chemical Name
2,2-Difluoropropionic acid
Synonyms
2,2-Difluoropropanoic acid;2,2-DIFLUOROPROPIONIC ACID;Propanoic acid, 2,2-difluoro-;2,2-Difluoropropionic acid 97%
CBNumber
CB1301258
Molecular Formula
C3H4F2O2
Formula Weight
110.06
MOL File
373-96-6.mol
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2,2-Difluoropropionic acid Property

Melting point:
38-45 °C
Boiling point:
25-30 °C/5 mmHg
Density 
1.316±0.06 g/cm3(Predicted)
Flash point:
25-30°C/5mm
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to crystal
pka
1.34±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C3H4F2O2/c1-3(4,5)2(6)7/h1H3,(H,6,7)
InChIKey
PMWGIVRHUIAIII-UHFFFAOYSA-N
SMILES
C(O)(=O)C(F)(F)C
CAS DataBase Reference
373-96-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C
Risk Statements 
34-36
Safety Statements 
26-36/37/39
RIDADR 
3261
WGK Germany 
3
HazardClass 
8
PackingGroup 
III
HS Code 
29159000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
684686
Product name
2,2-Difluoropropionic acid
Purity
97%
Packaging
250mg
Price
$578.55
Updated
2025/07/31
TCI Chemical
Product number
D5531
Product name
2,2-Difluoropropionic Acid
Packaging
1G
Price
$50
Updated
2025/07/31
TRC
Product number
D455898
Product name
2,2-Difluoropropionic Acid
Packaging
500mg
Price
$60
Updated
2021/12/16
TRC
Product number
D455898
Product name
2,2-Difluoropropionic Acid
Packaging
1g
Price
$75
Updated
2021/12/16
TRC
Product number
D455898
Product name
2,2-Difluoropropionic Acid
Packaging
100mg
Price
$45
Updated
2021/12/16
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2,2-Difluoropropionic acid Chemical Properties,Usage,Production

Uses

2,2-Difluoropropionic acid is a useful research chemical.

Application

2,2-Difluoropropionic acid is mainly used in biochemical research.

Chemical Properties

White powder

Synthesis

28781-85-3

373-96-6

The general procedure for synthesizing 2,2-difluoropropionic acid from ethyl 2,2-difluoropropionate was as follows: referring to Example G38, ethyl 2,2-difluoropropionate (1.2 g, 8.8 mmol) was dissolved in ethanol (26 mL), followed by the slow addition of 2N aqueous sodium hydroxide solution (26 mL). The reaction mixture was stirred at 0 °C, then gradually warmed to room temperature and continued stirring for 14 hours. Upon completion of the reaction, the reaction mixture was acidified to pH < 7 with 2N hydrochloric acid and then extracted with ether. The organic phases were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 2,2-difluoropropionic acid (0.90 g, 92% yield). The product was an oil with the following 1H-NMR (CDCl3) data: δ 1.85 (3H, t, J = 19.0 Hz), 6.21 (1H, br s).

References

[1] Patent: EP1402900, 2004, A1
[2] Patent: US2004/53973, 2004, A1
[3] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, p. 1260 - 1263
[4] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 7, p. 1417 - 1420
[5] Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 1597 - 1601

2,2-Difluoropropionic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,2-Difluoropropionic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2,2-Difluoropropionic acid 373-96-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Henan Aochuang Chemical Co.,Ltd.
Product
2,2-Difluoropropionic acid 373-96-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2025-04-01
Zjartschem
Product
2,2-Difluoropropionic acid 373-96-6
Price
US $0.00/kg
Min. Order
100g
Purity
97%
Supply Ability
100kg
Release date
2019-02-13

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