ChemicalBook > CAS DataBase List > 4-Hydroxymethyl-1H-indazole
4-Hydroxymethyl-1H-indazole
- Product Name
- 4-Hydroxymethyl-1H-indazole
- CAS No.
- 709608-85-5
- Chemical Name
- 4-Hydroxymethyl-1H-indazole
- Synonyms
- (1H-Indazol-4-yl);1H-INDAZOLE-4-METHANOL;(1H-indazol-4-yl)methanol;4-Hydroxymethyl-1H-indazole
- CBNumber
- CB12129287
- Molecular Formula
- C8H8N2O
- Formula Weight
- 148.16
- MOL File
- 709608-85-5.mol
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4-Hydroxymethyl-1H-indazole Property
- Boiling point:
- 380.3±17.0 °C(Predicted)
- Density
- 1.360±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 13.92±0.40(Predicted)
- color
- Grey to beige to brown
- CAS DataBase Reference
- 709608-85-5
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Safety
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
AK Scientific
- Product number
- Y5530
- Product name
- 4-(Hydroxymethyl)-1H-indazole
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H01-1-09
- Product name
- 1H-Indazole-4-methanol
- Purity
- 97%
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H01-1-09
- Product name
- 1H-Indazole-4-methanol
- Purity
- 97%
- Packaging
- 5G
- Price
- $215
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 132398
- Product name
- (1H-Indazol-4-yl)methanol
- Purity
- 97%
- Packaging
- 5g
- Price
- $580
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 132398
- Product name
- (1H-Indazol-4-yl)methanol
- Purity
- 97%
- Packaging
- 25g
- Price
- $1625
- Updated
- 2021/12/16
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4-Hydroxymethyl-1H-indazole Chemical Properties,Usage,Production
Synthesis
192945-49-6
709608-85-5
General procedure for the synthesis of 4-(hydroxymethyl)-1H-indazole from methyl indazole-4-carboxylate: synthesis of (1H-indazol-4-yl)-methanol (18b): the ester obtained above (40 mg, 0.23 mmol) was dissolved in 1 mL of tetrahydrofuran (THF) and the solution was cooled to 0°C. A THF solution (1.0 M, 2.3 mL, 2.3 mmol) of diisobutylaluminum hydride (DIBAL) was added slowly and dropwise. The addition of DIBAL was continued until the feedstock was completely consumed. Upon completion of the reaction, the reaction was quenched with saturated sodium potassium tartrate solution and gradually warmed to room temperature. The reaction mixture was extracted using ethyl acetate. The organic phases were combined and dried with anhydrous magnesium sulfate (MgSO4). Subsequently, the solvent was removed by reduced pressure distillation and the residue was purified by column chromatography (75% ethyl acetate/hexane). The final target product (20 mg, 60% yield) was obtained as a white solid. Mass spectrometry (electrospray ionization) analysis showed that the theoretical value of M + H = 149.1 and the measured value = 149.1.
References
[1] Patent: WO2007/51062, 2007, A2. Location in patent: Page/Page column 126-127
4-Hydroxymethyl-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Hydroxymethyl-1H-indazole manufacturers
Career Henan Chemical Co
- Product
- 4-Hydroxymethyl-1H-indazole 709608-85-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2019-12-30
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