6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER
- Product Name
- 6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER
- CAS No.
- 885518-49-0
- Chemical Name
- 6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER
- Synonyms
- Methyl 6-bromo-(1H)-indaz...;6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER;6-BroMo-1H-indazol-4-carboxylic acid Methyl ester;6-BroMo-1H-indazole-4-carboxylic acid Methyl ester;1H-Indazole-4-carboxylic acid, 6-broMo-, Methyl ester;1H-Indazole-4-carboxylic acid, 6-bromo-, methyl ester (9CI, ACI)
- CBNumber
- CB0128102
- Molecular Formula
- C9H7BrN2O2
- Formula Weight
- 255.07
- MOL File
- Mol file
6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER Property
- Boiling point:
- 395.9±22.0 °C(Predicted)
- Density
- 1.709±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.21±0.40(Predicted)
- Appearance
- light yellow solid
- InChI
- InChI=1S/C9H7BrN2O2/c1-14-9(13)6-2-5(10)3-8-7(6)4-11-12-8/h2-4H,1H3,(H,11,12)
- InChIKey
- FEPRHRPOKPTRQZ-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(C(OC)=O)=CC(Br)=C2)C=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- J91322
- Product name
- Methyl6-bromo-1H-indazole-4-carboxylate
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
- Product number
- 4H23-9-04
- Product name
- Methyl 6-bromo-1H-indazole-4-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-B0755
- Product name
- methyl6-bromo-1H-indazole-4-carboxylate
- Packaging
- 5g
- Price
- $62
- Updated
- 2021/12/16
- Product number
- 4H23-9-04
- Product name
- Methyl 6-bromo-1H-indazole-4-carboxylate
- Purity
- 98%
- Packaging
- 5G
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J91322
- Product name
- Methyl6-bromo-1H-indazole-4-carboxylate
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
Methyl 6-bromo-4-indazolecarboxylate is mainly used as an organic synthesis intermediate and is widely used in drug development and chemical research.
Synthesis
1346597-55-4
885518-49-0
Step 6: Synthesis of methyl 6-bromo-1H-indazole-4-carboxylate To a stirred solution of methyl 1-acetyl-6-bromo-1H-indazole-4-carboxylate (18 g, 61.0 mmol) in methanol (350 mL) was slowly added 6N HCl (350 mL). The reaction mixture was stirred at 60 °C for 8 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Subsequently, the reaction mixture was alkalized with saturated NaHCO3 solution to pH 8. The precipitated solid was collected by filtration and dried under vacuum. The dried solid was stirred in ether for 15 min, filtered again and dried to give methyl 6-bromo-1H-indazole-4-carboxylate (11 g, 71.7% yield).
References
[1] Patent: WO2012/118812, 2012, A2. Location in patent: Page/Page column 313
[2] Patent: CN105037360, 2016, B. Location in patent: Paragraph 0400; 0401; 0402
6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER manufacturers
- Product
- 6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER 885518-49-0
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-08-08
- Product
- 6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER 885518-49-0
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-04
- Product
- 6-BroMo-4-indazolecarboxylic acid Methyl ester 885518-49-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-10