METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE
Uses- Product Name
- METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE
- CAS No.
- 65202-50-8
- Chemical Name
- METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE
- Synonyms
- KML-38;CML-037;AKOS 91997;TERT-BUTYL 4-(2-AM...;Methyl 3-chloropyridazine...;6-Chloro-3-(methoxycarbonyl)pyridazine;Methyl 3-chloropyridazine-6-carboxylate;METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE;6-Chloropyridazine-3-carboxylic acid methyl ester;3-Pyridazinecarboxylic acid, 6-chloro-, Methyl ester
- CBNumber
- CB3802007
- Molecular Formula
- C6H5ClN2O2
- Formula Weight
- 172.57
- MOL File
- 65202-50-8.mol
METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE Property
- Melting point:
- 145 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 310.9±22.0 °C(Predicted)
- Density
- 1.372±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder
- pka
- -1.06±0.10(Predicted)
- color
- Grey
- InChI
- InChI=1S/C6H5ClN2O2/c1-11-6(10)4-2-3-5(7)9-8-4/h2-3H,1H3
- InChIKey
- FPKXYXKLOWAIOX-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NN=C(Cl)C=C1
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M295628
- Product name
- Methyl6-chloropyridazine-3-carboxylate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR2978
- Product name
- Methyl6-chloropyridazine-3-carboxylate
- Packaging
- 100mg
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 057947
- Product name
- Methyl 6-chloropyridazine-3-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- OR2978
- Product name
- Methyl6-chloropyridazine-3-carboxylate
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- W7653
- Product name
- Methyl6-chloropyridazine-3-carboxylate
- Packaging
- 5g
- Price
- $143
- Updated
- 2021/12/16
METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE Chemical Properties,Usage,Production
Uses
6-Chlorpyridazine-3-carboxylic acid methyl ester is a carboxylic acid ester compound that can be used as a key intermediate in the synthesis of compounds with lipid-lowering, anti-tumor proliferation activity, and pesticides.
Chemical Properties
Solid
Synthesis
63001-30-9
65202-50-8
B. Methyl 6-hydroxypyridazine-3-carboxylate prepared as described above was mixed with phosphorochloridic acid, slowly heated to reflux temperature and the reaction was maintained for 2.5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the excess phosphoryl chloride was subsequently evaporated under reduced pressure. The residue was carefully decanted into ice water and the precipitated solid was collected by filtration. The precipitate was washed sequentially with saturated sodium bicarbonate solution and deionized water and finally dried in a vacuum drying oven to afford the target product, methyl 6-chloropyridazine-3-carboxylate, as a yellow solid (4.359 g, 79% yield).
References
[1] Patent: EP2316827, 2016, B1. Location in patent: Paragraph 0124
[2] Patent: EP3333157, 2018, A1. Location in patent: Paragraph 0375; 0376; 0394; 0395
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 9, p. 3814 - 3830
METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE manufacturers
- Product
- Methyl 6-chloropyridazine-3-carboxylate 65202-50-8
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-19
- Product
- Methyl 6-chloropyridazine-3-carboxylate 65202-50-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-13
- Product
- METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE 65202-50-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-01