6-Chloro-pyridazine-3-carboxylic acid ethyl ester
- Product Name
- 6-Chloro-pyridazine-3-carboxylic acid ethyl ester
- CAS No.
- 75680-92-1
- Chemical Name
- 6-Chloro-pyridazine-3-carboxylic acid ethyl ester
- Synonyms
- 6-chlorodazine-3-ethyl formate;ethyl 4-chloropyriMidine-2-carboxylate;Ethyl 6-chloropyridazine-3-carboxylate;Ethyl 6-chloro-3-pyridazinecarboxylate;6-Chloro-pyridazine-3-carboxylic acid ethyl ester;3-Pyridazinecarboxylic acid, 6-chloro-, ethyl ester;6-Chloro-pyridazine-3-carboxylic acid ethyl ester ISO 9001：2015 REACH
- CBNumber
- CB31113382
- Molecular Formula
- C7H7ClN2O2
- Formula Weight
- 186.6
- MOL File
- 75680-92-1.mol
6-Chloro-pyridazine-3-carboxylic acid ethyl ester Property
- Melting point:
- 147-149 °C
- Boiling point:
- 320.1±22.0 °C(Predicted)
- Density
- 1.311±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Crystalline Powder
- pka
- -0.94±0.10(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C7H7ClN2O2/c1-2-12-7(11)5-3-4-6(8)10-9-5/h3-4H,2H2,1H3
- InChIKey
- GVSVPKDEHFOXSW-UHFFFAOYSA-N
- SMILES
- C1(C(OCC)=O)=NN=C(Cl)C=C1
Safety
- HS Code
- 29339980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E903558
- Product name
- Ethyl6-chloropyridazine-3-carboxylate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- W8288
- Product name
- Ethyl6-chloro-3-pyridazinecarboxylate
- Packaging
- 1g
- Price
- $141
- Updated
- 2021/12/16
- Product number
- FC59739
- Product name
- 6-Chloro-pyridazine-3-carboxylic acid ethyl ester
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FC59739
- Product name
- 6-Chloro-pyridazine-3-carboxylic acid ethyl ester
- Packaging
- 2g
- Price
- $230
- Updated
- 2021/12/16
- Product number
- W8288
- Product name
- Ethyl6-chloro-3-pyridazinecarboxylate
- Packaging
- 5g
- Price
- $320
- Updated
- 2021/12/16
6-Chloro-pyridazine-3-carboxylic acid ethyl ester Chemical Properties,Usage,Production
Uses
Ethyl 6-Chloropyridazine-3-carboxylate is a useful research chemical compound used in the preparation of hetero-substituted pyridazine derivatives using alkylation of chloropyridazinecarboxylate followed by cross-coupling and heterocyclization.
Synthesis
63001-31-0
75680-92-1
Ethyl 3-pyridazinone-6-carboxylate (1.17 g, 6.96 mmol) was used as a raw material, which was dissolved in phosphoryl chloride (12 mL) and the reaction was heated at 100 °C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to about 3 mL. The concentrated residue was slowly poured into ice water and slowly neutralized with 10% aqueous sodium hydroxide solution under ice bath conditions. The neutralized mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution and subsequently dried with anhydrous magnesium sulfate. The dried organic phase was evaporated under reduced pressure to give the crude product. The crude product was purified by rapid chromatography on silica gel (200-300 mesh, eluent ratio hexane: ethyl acetate = 3:1) to afford ethyl 6-chloropyridazine 3-carboxylate (892 mg, yield 68.7%) as a white solid. The melting point was measured to be 145.6-146.7 °C (literature values 154-155 °C [56]).
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 598 - 611
[2] Patent: CN106187910, 2016, A. Location in patent: Paragraph 0242; 0243
[3] Nippon Kagaku Zasshi, 1957, vol. 78, p. 577,579, 580
[4] Chem.Abstr., 1959, p. 5275
[5] Bulletin de la Societe Chimique de France, 1959, p. 1793,1796
6-Chloro-pyridazine-3-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloro-pyridazine-3-carboxylic acid ethyl ester manufacturers
- Product
- ethyl 6-chloropyridazine-3-carboxylate 75680-92-1
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-19
- Product
- ethyl 6-chloropyridazine-3-carboxylate 75680-92-1
- Price
- US $2.90/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-24
- Product
- 6-Chloro-Pyridazine-3-Carboxylic Acid Ethyl Ester 75680-92-1
- Price
- US $2.90/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2021-09-24