6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
- Product Name
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
- CAS No.
- 35570-68-4
- Chemical Name
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
- Synonyms
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H);6-Chloro-3H-oxazolo[4,5-b]pyridin-2-one;6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one;6-chlorooxazole[4,5-b]pyridine-2(3H)-one;Oxazolo[4,5-b]pyridin-2(3H)-one, 6-chloro-;6-chloro-3H-[1,3]oxazolo[4,5-b]pyridin-2-one;6-chloro[1,3]oxazolo[4,5-b]pyridin-2(3H)-one;6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one （Crizotinib intermediate）
- CBNumber
- CB82484862
- Molecular Formula
- C6H3ClN2O2
- Formula Weight
- 170.55
- MOL File
- 35570-68-4.mol
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one Property
- Melting point:
- 183-186℃
- Density
- 1.80
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C374938
- Product name
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
- Packaging
- 500mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- OR939132
- Product name
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $435
- Updated
- 2021/12/16
- Product number
- OR939132
- Product name
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
- Purity
- 95%
- Packaging
- 250mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 4439AB
- Product name
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
- Packaging
- 5g
- Price
- $232
- Updated
- 2021/12/16
- Product number
- HCH0368023
- Product name
- 6-CHLOROOXAZOLO-[4,5-B]PYRIDIN-2(3H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.11
- Updated
- 2021/12/16
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one Chemical Properties,Usage,Production
Synthesis
60832-72-6
35570-68-4
The general procedure for the synthesis of 6-chloro-oxazolo[4,5-b]pyridin-2(3H)-one using 2,3-dihydropyrido[2,3-d][1,3]oxazol-2-one as starting material was as follows: first, DMF (9 L) was added to a 100 L autoclave, a mechanical stirrer was started, and 2,3-dihydropyrido[2,3-d][1,3]oxazol-2-one ( 10 kg) and stirred until completely dissolved. Subsequently, N-chlorosuccinimide (12.16 kg) was dissolved in DMF (30 L) and slowly added dropwise to the reactor, during which the temperature of the reaction was controlled not to exceed 40 °C (cooled by a circulating condensate pump if necessary). After dropwise addition, the reaction mixture was stirred at room temperature overnight. The reaction progress was monitored by TLC and GC. Upon completion of the reaction, water (39 L) was slowly added under cooling conditions and stirring was continued for 60 minutes before filtration. The filter cake was washed twice with water and subsequently dried under vacuum to give a crude product of 11.8 kg.Finally, the crude product was recrystallized by dichloromethane and ethyl acetate to give the pure product 6-chloroxazolo[4,5-b]pyridin-2(3H)-one (11.1 kg) in 89% yield.
References
[1] Patent: CN103709175, 2016, B. Location in patent: Paragraph 0024-0025
[2] Patent: CN103755627, 2016, B. Location in patent: Paragraph 0022; 0023
[3] Patent: WO2018/37223, 2018, A1. Location in patent: Page/Page column 222
[4] Helvetica Chimica Acta, 1976, vol. 59, p. 1593 - 1612
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one manufacturers
- Product
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 35570-68-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-31
- Product
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 35570-68-4
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04