6-Chloropyridazine-3-carboxylic acid

Product Name: 6-Chloropyridazine-3-carboxylic acid
CAS No.: 5096-73-1
Chemical Name: 6-Chloropyridazine-3-carboxylic acid
Synonyms: KML-37;CML-036;TERT-BUTYL 4-CYANO...;3-Carboxy-6-chloropyridazine;3-Chloropyridazine-6-carb...;6-CHLORO-3-CARBOXY-PYRIDAZINE;6-CHLOROPYRIDAZINE-3-CARBOXYLIC ACID;3-chloropyridazine-6-carboxylic acid;6-CHLORO-3-PYRIDAZINE-CARBOXYLIC ACID;6-Chloropyridazine-3-caSNoxylic acid
CBNumber: CB3480793
Molecular Formula: C5H3ClN2O2
Formula Weight: 158.54
MOL File: 5096-73-1.mol

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6-Chloropyridazine-3-carboxylic acid Property

Melting point:: 146 °C
Boiling point:: 429.0±25.0 °C(Predicted)
Density: 1.579±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 2.68±0.10(Predicted)
form: Crystalline Powder
color: White to cream
InChI: InChI=1S/C5H3ClN2O2/c6-4-2-1-3(5(9)10)7-8-4/h1-2H,(H,9,10)
InChIKey: HHGZQZULOHYEOH-UHFFFAOYSA-N
SMILES: C1(C(O)=O)=NN=C(Cl)C=C1
CAS DataBase Reference: 5096-73-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 29339980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: C380550
Product name: 6-Chloropyridazine-3-carboxylicacid
Packaging: 1g
Price: $140
Updated: 2021/12/16

AK Scientific

Product number: J95023
Product name: 6-Chloro-3-pyridazine-carboxylicacid
Packaging: 25g
Price: $120
Updated: 2021/12/16

Apolloscientific

Product number: OR6298
Product name: 6-Chloropyridazine-3-carboxylicacid
Purity: 97%
Packaging: 5g
Price: $37
Updated: 2021/12/16

Apolloscientific

Product number: OR6298
Product name: 6-Chloropyridazine-3-carboxylicacid
Purity: 97%
Packaging: 500mg
Price: $15
Updated: 2021/12/16

AK Scientific

Product number: J95023
Product name: 6-Chloro-3-pyridazine-carboxylicacid
Packaging: 1g
Price: $15
Updated: 2021/12/16

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6-Chloropyridazine-3-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

6-Chloropyridazine-3-carboxylic acid is Brown green powder

Uses

6-Chloropyridazine-3-carboxylic acid is a pyradazine derivative used in the preparation of stearoyl-CoA desaturase inhibitors.

Synthesis

75680-92-1

5096-73-1

General procedure for the synthesis of 6-chloropyridazine-3-carboxylic acid from ethyl 6-chloropyridazine-3-carboxylate: (Step-1) To a solution of ethyl 6-chloropyridazine-3-carboxylate (1.00 g, 5.36 mmol) in tetrahydrofuran (THF, 10 mL) was added a solution of lithium hydroxide (LiOH, 0.655 g, 26.8 mmol, 5 equiv) in water (10 mL). The reaction mixture was stirred at room temperature for 45 minutes. Upon completion of the reaction, the mixture was poured into 2 M hydrochloric acid and extracted with dichloromethane (DCM). The organic phases were combined and concentrated under reduced pressure to give 6-chloropyridazine-3-carboxylic acid as a white solid (770 mg, 91% yield).LC-MS (positive ESI): m/z 159/161 [M+H]+.

References

[1] Patent: WO2015/67701, 2015, A1. Location in patent: Page/Page column 44

6-Chloropyridazine-3-carboxylic acid Preparation Products And Raw materials

Raw materials

3-Chloro-6-methylpyridazine 2,5-HEPTANEDIONE Hydrazinium hydroxide solution Ethanol Phosphorus oxitrichloride Potassium dichromate Ethyl acetate Hydrochloric acid Potassium permanganate Sodium hydroxide Sulfuric acid

Preparation Products

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6-Chloropyridazine-3-carboxylic acid Suppliers

Canada 1 China 171 Germany 1 India 3 United Kingdom 6 United States 17 Global 199

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View Lastest Price from 6-Chloropyridazine-3-carboxylic acid manufacturers

Dideu Industries Group Limited

Product: 6-Chloropyridazine-3-carboxylic acid 5096-73-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-11-01

Career Henan Chemical Co

Product: 6-Chloropyridazine-3-carboxylic acid 5096-73-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000KG
Release date: 2018-12-16

5096-73-1, 6-Chloropyridazine-3-carboxylic acidRelated Search:

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REF DUPL: 3-Chloropyridazine-6-carboxylic acid

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6-Chloropyridazine-3-carboxylic acid ISO 9001：2015 REACH

KML-37

5096-73-1

C5H2ClN2NaO2

pyridazine

Building Blocks

Carboxylic Acids

Pyrazines, Pyrimidines & Pyridazines

Pyridazine series

Carboxylic Acids

Pyrazines, Pyrimidines & Pyridazines

API