3-Chloro-6-methylpyridazine

Product Name: 3-Chloro-6-methylpyridazine
CAS No.: 1121-79-5
Chemical Name: 3-Chloro-6-methylpyridazine
Synonyms: NSC 18704;AKOS BBS-00001551;3-Chloro-6-Methyl;Chloro-6-methylpyridazine;3-Chloro-6-Methylpridazine;6-Chloro-3-methylpyridazine;3-CHLORO-6-METHYLPYRIDAZINE;3-Chloro-6-methylpyridazi...;3-Chloro-6-methyl-1,2-diazine;pyridazine, 3-chloro-6-methyl-
CBNumber: CB0420800
Molecular Formula: C5H5ClN2
Formula Weight: 128.56
MOL File: 1121-79-5.mol

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3-Chloro-6-methylpyridazine Property

Melting point:: 58-62 °C
Boiling point:: 58 °C
Density: 1.234±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO, Methanol (Slightly)
form: Solid
pka: 1.26±0.10(Predicted)
color: Pale Beige
BRN: 108655
InChI: InChI=1S/C5H5ClN2/c1-4-2-3-5(6)8-7-4/h2-3H,1H3
InChIKey: PRORLQAJNJMGAR-UHFFFAOYSA-N
SMILES: C1(Cl)=NN=C(C)C=C1
CAS DataBase Reference: 1121-79-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38-43-41-38-22
Safety Statements: 26-37/39-36/37-37
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT
HS Code: 29339900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 637637
Product name: 3-Chloro-6-methylpyridazine
Purity: 97%
Packaging: 5g
Price: $53.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 637637
Product name: 3-Chloro-6-methylpyridazine
Purity: 97%
Packaging: 1g
Price: $25
Updated: 2023/06/20

TCI Chemical

Product number: C2274
Product name: 3-Chloro-6-methylpyridazine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $109
Updated: 2025/07/31

TCI Chemical

Product number: C2274
Product name: 3-Chloro-6-methylpyridazine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $385
Updated: 2025/07/31

TRC

Product number: C365550
Product name: 3-Chloro-6-methylpyridazine
Packaging: 25g
Price: $180
Updated: 2021/12/16

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3-Chloro-6-methylpyridazine Chemical Properties,Usage,Production

Chemical Properties

colorless to yellow liquid

Uses

3-Chloro-6-methylpyridazine is used for preparation of heterocyclic compounds as integrase inhibiting antiviral agents.

Reactions

3-Chloro-6-methyl pyridazine can undergo nickel catalyzed cross coupling reaction with aromatic and heteroaromatic halides, to give the corresponding substituted aryl- and heteroaryl pyridazines.

Definition

ChEBI: 3-Chloro-6-methylpyridazine is a member of pyridazines.

Pharmaceutical Applications

3-Chloro-6-methylpyridazine can be used in the synthesis of a p38MAP kinase inhibitor with therapeutic potential in the treatment of autoimmune and inflammatory diseases.

Synthesis

Add 6-methyl-3(2H)-pyridazinone and chlorinating agent to the reaction vessel; POCl₃ can act as solvent if used. Heat to 80–120℃, reflux for 2–6 hours to substitute the hydroxyl group of pyridazinone with chlorine. After reaction, slowly pour the solution into ice water to quench excess chlorinating agent, adjust pH to neutral with sodium carbonate or sodium hydroxide. Extract with dichloromethane, ethyl acetate, etc., dry the extract with anhydrous sodium sulfate, remove solvent by reduced pressure distillation to get crude product. Purify via recrystallization (e.g., ethanol-water solvent) or column chromatography to obtain high-purity 3-chloro-6-methylpyridazine.

3-Chloro-6-methylpyridazine Preparation Products And Raw materials

Raw materials

Preparation Products

6-Chloropyridazine-3-carboxylic acid

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3-Chloro-6-methylpyridazine Suppliers

Americas 1 Belgium 2 Canada 1 China 252 China Hong Kong 1 Europe 3 Germany 9 India 11 Japan 1 Switzerland 3 Ukraine 1 United Kingdom 14 United States 37 Global 336

Shanghai YiWen Pharmaceutical Co., Ltd.

Tel: 13621628489
Email: 1322392736@qq.com
Country: China
ProdList: 263
Advantage: 58

Anhui Shite Pharmaceutical Technology Co., LTD

Tel: 0555-8228058 13621628489
Fax: 0512-63261912
Email: sales1@stepuppharm.com
Country: China
ProdList: 259
Advantage: 55

SiChuang NanBu Honesty Technology Co., Ltd.

Tel: 0838-5675166 15883665058
Fax: 0838-5675535
Email: nbcxkj@126.com
Country: China
ProdList: 933
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Sichuan Ruibo Technology Co., Ltd

Tel: +86-817-5586080
Fax: +86-817-5527378
Country: China
ProdList: 42
Advantage: 69

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

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View Lastest Price from 3-Chloro-6-methylpyridazine manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3-Chloro-6-methylpyridazine 1121-79-5
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-02

Shanghai Rlavie Technology Co ltd

Product: 3-Chloro-6-methylpyridazine 1121-79-5
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%minHPLC
Supply Ability: 100kgs/month
Release date: 2021-11-13

Dideu Industries Group Limited

Product: 3-Chloro-6-methylpyridazine 1121-79-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-11-01

1121-79-5, 3-Chloro-6-methylpyridazineRelated Search:

3-CHLORO-6-PHENYLPYRIDAZINE Hydrochlorothiazide Sulfachloropyridazine sodium Hydralazine Thioridazine Tetramethylpyrazine 6-chloro-N-(propan-2-yl)pyridazin-3-amine 3-chloro-6-(chloroMethyl)pyridazine hydrochloride 3-Chloro-6-trifluoromethyl-pyridazine 3-Chloro-6-chloromethylpyridazine 3-chloro-6-isopropylpyridazine 3-CHLORO-6-PROPYLOXYPYRIDAZINE 3-CHLORO-6-ISOPROPOXYPYRIDAZINE 3-Chloro-6-hydrazinopyridazine 3-Chloro-6-(1H-pyrazol-1-yl)pyridazine 6-Chloro-N-ethylpyridazin-3-amine 3-(TERT-BUTOXY)-6-CHLOROPYRIDAZINE 3-Chloro-6-iodopyridazine

3-CHLORO-6-METHYLPYRIDAZINE

AKOS BBS-00001551

6-Chloro-3-methylpyridazine

Chloro-6-methylpyridazine

3-Chloro-6-Methyl

pyridazine, 3-chloro-6-methyl-

3-Chloro-6-methylpyridazi...

3-Chloro-6-methyl-1,2-diazine

NSC 18704

3-Chloro-6-Methylpridazine

3-Chloro-6-methylpyridazine,97%

3-Chloro-6-methylpyridazine 97%

3-Chloro-6-Methylpyridazine, 98.0%(GC&T

3-Chloro-6-methylpyridazine &gt

3-Chloro-6-methylpyridazine ISO 9001：2015 REACH

1121-79-5

Building Blocks

Pyridazines

Halogenated Heterocycles

Heterocyclic Building Blocks

Building Blocks

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

v

alkyl chloride

Heterocycles

Pyrazines, Pyrimidines & Pyridazines

PyridazinesHeterocyclic Building Blocks

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridazines

Halides

Pyrazines, Pyrimidines & Pyridazines

Pyridazine series