ChemicalBook > CAS DataBase List > 6-Chloropyridazine-3-carboxylic acid

6-Chloropyridazine-3-carboxylic acid

Product Name
6-Chloropyridazine-3-carboxylic acid
CAS No.
5096-73-1
Chemical Name
6-Chloropyridazine-3-carboxylic acid
Synonyms
KML-37;CML-036;TERT-BUTYL 4-CYANO...;3-Carboxy-6-chloropyridazine;3-Chloropyridazine-6-carb...;6-CHLORO-3-CARBOXY-PYRIDAZINE;6-CHLOROPYRIDAZINE-3-CARBOXYLIC ACID;3-chloropyridazine-6-carboxylic acid;6-CHLORO-3-PYRIDAZINE-CARBOXYLIC ACID;6-Chloropyridazine-3-caSNoxylic acid
CBNumber
CB3480793
Molecular Formula
C5H3ClN2O2
Formula Weight
158.54
MOL File
5096-73-1.mol
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6-Chloropyridazine-3-carboxylic acid Property

Melting point:
146 °C
Boiling point:
429.0±25.0 °C(Predicted)
Density 
1.579±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
2.68±0.10(Predicted)
form 
Crystalline Powder
color 
White to cream
InChI
InChI=1S/C5H3ClN2O2/c6-4-2-1-3(5(9)10)7-8-4/h1-2H,(H,9,10)
InChIKey
HHGZQZULOHYEOH-UHFFFAOYSA-N
SMILES
C1(C(O)=O)=NN=C(Cl)C=C1
CAS DataBase Reference
5096-73-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
29339980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
C380550
Product name
6-Chloropyridazine-3-carboxylicacid
Packaging
1g
Price
$140
Updated
2021/12/16
AK Scientific
Product number
J95023
Product name
6-Chloro-3-pyridazine-carboxylicacid
Packaging
25g
Price
$120
Updated
2021/12/16
Apolloscientific
Product number
OR6298
Product name
6-Chloropyridazine-3-carboxylicacid
Purity
97%
Packaging
5g
Price
$37
Updated
2021/12/16
Apolloscientific
Product number
OR6298
Product name
6-Chloropyridazine-3-carboxylicacid
Purity
97%
Packaging
500mg
Price
$15
Updated
2021/12/16
AK Scientific
Product number
J95023
Product name
6-Chloro-3-pyridazine-carboxylicacid
Packaging
1g
Price
$15
Updated
2021/12/16
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6-Chloropyridazine-3-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

6-Chloropyridazine-3-carboxylic acid is Brown green powder

Uses

6-Chloropyridazine-3-carboxylic acid is a pyradazine derivative used in the preparation of stearoyl-CoA desaturase inhibitors.

Synthesis

75680-92-1

5096-73-1

General procedure for the synthesis of 6-chloropyridazine-3-carboxylic acid from ethyl 6-chloropyridazine-3-carboxylate: (Step-1) To a solution of ethyl 6-chloropyridazine-3-carboxylate (1.00 g, 5.36 mmol) in tetrahydrofuran (THF, 10 mL) was added a solution of lithium hydroxide (LiOH, 0.655 g, 26.8 mmol, 5 equiv) in water (10 mL). The reaction mixture was stirred at room temperature for 45 minutes. Upon completion of the reaction, the mixture was poured into 2 M hydrochloric acid and extracted with dichloromethane (DCM). The organic phases were combined and concentrated under reduced pressure to give 6-chloropyridazine-3-carboxylic acid as a white solid (770 mg, 91% yield).LC-MS (positive ESI): m/z 159/161 [M+H]+.

References

[1] Patent: WO2015/67701, 2015, A1. Location in patent: Page/Page column 44

6-Chloropyridazine-3-carboxylic acid Preparation Products And Raw materials

Raw materials

3-Chloro-6-methylpyridazine 2,5-HEPTANEDIONE Hydrazinium hydroxide solution Ethanol Phosphorus oxitrichloride Potassium dichromate Ethyl acetate Hydrochloric acid Potassium permanganate Sodium hydroxide Sulfuric acid

Preparation Products

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View Lastest Price from 6-Chloropyridazine-3-carboxylic acid manufacturers

Dideu Industries Group Limited
Product
6-Chloropyridazine-3-carboxylic acid 5096-73-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-11-01
Career Henan Chemical Co
Product
6-Chloropyridazine-3-carboxylic acid 5096-73-1
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000KG
Release date
2018-12-16

5096-73-1, 6-Chloropyridazine-3-carboxylic acidRelated Search:

6-Chloro-pyridazine-3-carboxylic acid ethyl ester Benzyl chloroformate Thioridazine Sulfachoropyrazine sodium (+)-MENTHYL CHLOROFORMATE Sulfachloropyridazine sodium Allyl chloroformate Hydralazine 3-Chloroperoxybenzoic acid Hydrochlorothiazide 6-Chloropyridazine-3-carboxamide 2-Pyrazinecarboxylic acid, 6-chloro-, ethyl ester 6-Chloropyrazine-2-carboxylic acid 3-Pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester Methyl chloroformate t-butyl chloroformate Ethyl chloroformate 3,6-Dichloropyridazine-4-carboxylic acid

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