METHYL 6-FORMYLNICOTINATE

Product Name: METHYL 6-FORMYLNICOTINATE
CAS No.: 10165-86-3
Chemical Name: METHYL 6-FORMYLNICOTINATE
Synonyms: METHY 6-FORMYLNICOTINATE;METHYL 6-FORMYLNICOTINATE;Methyl 6-formylpyridin-3-carboxylate;Methyl 6-formylpyridine-3-carboxylate;methyl 2-formylpyridine-5-carboxylate;6-Formylpyridine-3-carboxylic acid methyl ester;3-Pyridinecarboxylic acid, 6-forMyl-, Methyl ester
CBNumber: CB2347794
Molecular Formula: C8H7NO3
Formula Weight: 165.15
MOL File: 10165-86-3.mol

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METHYL 6-FORMYLNICOTINATE Property

Melting point:: 115-116.7 °C
Boiling point:: 273℃
Density: 1.249
Flash point:: 119℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 1.68±0.10(Predicted)
color: Yellow to brown
InChI: InChI=1S/C8H7NO3/c1-12-8(11)6-2-3-7(5-10)9-4-6/h2-5H,1H3
InChIKey: BZOWIADSJYMJJJ-UHFFFAOYSA-N
SMILES: C1=NC(C=O)=CC=C1C(OC)=O

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41
Safety Statements: 26-39-36
WGK Germany: WGK 3
HazardClass: IRRITANT
HS Code: 29333990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Dam. 1
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M305403
Product name: Methyl6-formylnicotinate
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 455801
Product name: Methyl 6-formylnicotinate
Packaging: 25mg
Price: $305
Updated: 2021/12/16

Apolloscientific

Product number: OR303729
Product name: Methyl 6-formylnicotinate
Packaging: 1g
Price: $195
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-7X
Product name: Methyl 6-formylnicotinate
Purity: 97%
Packaging: 1g
Price: $231
Updated: 2021/12/16

Apolloscientific

Product number: OR303729
Product name: Methyl 6-formylnicotinate
Packaging: 5g
Price: $582
Updated: 2021/12/16

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METHYL 6-FORMYLNICOTINATE Chemical Properties,Usage,Production

Synthesis Reference(s)

Tetrahedron, 64, p. 688, 2008 DOI: 10.1016/j.tet.2007.11.030

Synthesis

56026-36-9

10165-86-3

General procedure for the synthesis of methyl 6-formylnicotinate from methyl 6-hydroxymethylnicotinate: a mixture of methyl 6-hydroxymethylnicotinate (7 g, 37 mmol) and manganese dioxide (32.3 g, 372 mmol) in dichloromethane (200 mL) was stirred and reacted for 4 hours at 20°C. After completion of the reaction, the mixture was filtered and the filtrate was concentrated. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 5/1) to afford methyl 6-formylnicotinate (6 g, 97% yield). Mass spectral data: MS-ESI (m/z): 166.2 ([M + H]+) (LC-MS method C; retention time: 0.36 min).

References

[1] Patent: WO2014/114185, 2014, A1. Location in patent: Page/Page column 126
[2] Patent: US2014/206681, 2014, A1. Location in patent: Paragraph 0782
[3] Molecules, 2014, vol. 19, # 1, p. 102 - 121
[4] Patent: CN104418811, 2017, B. Location in patent: Paragraph 0234-0236
[5] Tetrahedron Letters, 2006, vol. 47, # 39, p. 7025 - 7029

METHYL 6-FORMYLNICOTINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 6-FORMYLNICOTINATE Suppliers

China 123 Germany 1 India 1 Switzerland 1 United Kingdom 3 United States 11 Global 140

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View Lastest Price from METHYL 6-FORMYLNICOTINATE manufacturers

Career Henan Chemical Co

Product: METHYL 6-FORMYLNICOTINATE 10165-86-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-25

10165-86-3, METHYL 6-FORMYLNICOTINATERelated Search:

Methyl 6-bromonicotinate METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE 6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER 3-Pyridinecarboxylic acid, 6-forMyl-, ethyl ester 6-FORMYL-2-PYRIDINE CARBOXYLIC ACID METHYL ESTER Nicotinic acid, 6-formyl- (8CI) 6-FORMYL-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER methyl 6-chloropyrimidine-4-carboxylate Methyl 6-bromoisoquinoline-1-carboxylate Methyl 6-bromohexanoate Methyl 6-chloronicotinate 6-CHLORO-2-PICOLINIC ACID METHYL ESTER METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE methyl 6-methylpyridine-2-carboxylate 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Methyl 6-bromo-2-naphthoate 6-METHYLPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER 2-Chloro-6-pyrazinecarboxylic acid methyl ester

METHYL 6-FORMYLNICOTINATE

3-Pyridinecarboxylic acid, 6-forMyl-, Methyl ester

methyl 2-formylpyridine-5-carboxylate

Methyl 6-formylpyridine-3-carboxylate

6-Formylpyridine-3-carboxylic acid methyl ester

METHY 6-FORMYLNICOTINATE

Methyl 6-formylpyridin-3-carboxylate

10165-86-3