6-FORMYL-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 6-FORMYL-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 391668-75-0
- Chemical Name
- 6-FORMYL-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- tert-Butyl 6-forMylindoline-1-carboxylate;tert-butyl 6-(hydroxymethyl)indole-1-carboxylate;6-methylolindole-1-carboxylic acid tert-butyl ester;6-(hydroxymethyl)-1-indolecarboxylic acid tert-butyl ester;6-FORMYL-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1H-Indole-1-carboxylic acid, 6-formyl-2,3-dihydro-, 1,1-dimethylethyl ester
- CBNumber
- CB02460983
- Molecular Formula
- C14H17NO3
- Formula Weight
- 247.29
- MOL File
- 391668-75-0.mol
6-FORMYL-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- Boiling point:
- 372.2±41.0 °C(Predicted)
- Density
- 1.186±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.56±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 3548AJ
- Product name
- 6-Formyl-2,3-dihydro-indole-1-carboxylicacidtert-butylester
- Packaging
- 1g
- Price
- $485
- Updated
- 2021/12/16
- Product number
- CHM0151267
- Product name
- 6-FORMYL-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Purity
- 96.00%
- Packaging
- 5G
- Price
- $3811.5
- Updated
- 2021/12/16
- Product number
- A404579
- Product name
- tert-Butyl6-formylindoline-1-carboxylate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $54
- Updated
- 2021/12/16
- Product number
- A404579
- Product name
- tert-Butyl6-formylindoline-1-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- 48R0324
- Product name
- 6-Formyl-2,3-dihydro-indole-1-carboxylicacidtert-butylester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $163
- Updated
- 2021/12/16
6-FORMYL-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Synthesis
214614-98-9
391668-75-0
Tert-butyl 6-(hydroxymethyl)indoline-1-carboxylate (163 mg, 0.654 mmol) was used as a raw material and dissolved in 3.2 mL of anhydrous dichloromethane. To this solution was added Dess-Martin periodinane (290 mg, 0.68 mmol) at room temperature. The reaction mixture was stirred at the same temperature for 30 min before the reaction was terminated by adding saturated aqueous NaHCO3 solution. Subsequently, the reaction mixture was extracted with ethyl acetate and the organic phase was washed with brine and dried with anhydrous MgSO4. After filtration to remove the desiccant, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with an eluent ratio of hexane/ethyl acetate (95/5 to 75/25) to afford tert-butyl 6-formylindoline-1-carboxylate as a white powder (140 mg, 86% yield).
References
[1] Patent: EP2123637, 2009, A1. Location in patent: Page/Page column 80
[2] Patent: US2003/232860, 2003, A1. Location in patent: Page 20
6-FORMYL-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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