(2-amino-3-hydroxy-octadecoxy)phosphonic acid

Product Name: (2-amino-3-hydroxy-octadecoxy)phosphonic acid
CAS No.: 19794-97-9
Chemical Name: (2-amino-3-hydroxy-octadecoxy)phosphonic acid
Synonyms: 2S-amino-1;SPHINGANINE-1-PHOSPHATE;dihydrosphingosine 1-phosphate;(2S,3R)-Sphinganine 1-Phosphate;Sphinganine-1-phosphate (d18:0);D-erythro-sphinganine-1-phosphate;C18-Dihydrosphingosine 1-Phosphate;(2-amino-3-hydroxy-octadecoxy)phosphonic acid;D-erythro-Dihydrosphingosine 1-phosphate;(2S,3R)-2-AMino-1,3-octadecanediol 1-(Dihydrogen Phosphate)
CBNumber: CB12129494
Molecular Formula: C18H40NO5P
Formula Weight: 381.49
MOL File: 19794-97-9.mol

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(2-amino-3-hydroxy-octadecoxy)phosphonic acid Property

Boiling point:: 548.2±60.0 °C(Predicted)
Density: 1.080±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: 0.3 M NaOH: 4 mg/ml; DMF: <50 μg/ml; DMSO: <50 μg/ml; Ethanol: <50 μg/ml; PBS (pH 7.2): <50 μg/ml
form: A crystalline solid
pka: 1.76±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D3439
Product name: <SC>D</SC>-<I>erythro</I>-Dihydrosphingosine 1-phosphate
Purity: ≥98% (TLC), waxy solid
Packaging: 1mg
Price: $282
Updated: 2025/07/31

Cayman Chemical

Product number: 22500
Product name: Sphinganine-1-phosphate (d18:0)
Purity: ≥95%
Packaging: 500μg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 22500
Product name: Sphinganine-1-phosphate (d18:0)
Purity: ≥95%
Packaging: 1mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 22500
Product name: Sphinganine-1-phosphate (d18:0)
Purity: ≥95%
Packaging: 5mg
Price: $419
Updated: 2024/03/01

TRC

Product number: D449500
Product name: D-erythro-Dihydro-D-sphingosine-1-phosphate
Packaging: 2mg
Price: $135
Updated: 2021/12/16

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(2-amino-3-hydroxy-octadecoxy)phosphonic acid Chemical Properties,Usage,Production

Chemical Properties

White to Beige Solid

Uses

(2-amino-3-hydroxy-octadecoxy)phosphonic acid may be used as a negative control for C2 Ceramide.

Definition

ChEBI: A sphingoid 1-phosphate that is the monophosphorylated derivative of sphinganine.

Biochem/physiol Actions

Negative control for sphingosine-1-phosphate.

in vivo

Sphinganine 1-phosphate can enhance wound healing in diabetic mice^[1]. Sphinganine 1-phosphate provides renal and hepatic protection after liver ischemia and reperfusion (IR) injury in mice through selective activation of S1P1 receptors and pertussis toxin-sensitive G-proteins with subsequent activation of ERK and Akt. Sphinganine 1-phosphate (administered 0.1 mg/kg i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion) protects against hepatic and renal injury after liver IR^[2].

Animal Model:	Male C57BL/6 mice (20-25?g)^[2]
Dosage:	0.1?mg/kg
Administration:	Administered i.v. immediately before reperfusion and 0.2?mg/kg s.c. 2 h after reperfusion
Result:	The plasma level of alanine aminotransferase (ALT) and Creatinine (Cr) was 80±6 U/L and 0.46±0.05 mg/dL, respectively. The increases in ALT (7474±557?U/L) and Cr (0.55±0.05?mg/dL) were significantly suppressed at 24?h after reperfusion in mice treated with 0.1?mg/kg i.v. before reperfusion and 0.2?mg/kg s.c. 2?h after reperfusion.

IC 50

Human Endogenous Metabolite

(2-amino-3-hydroxy-octadecoxy)phosphonic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-amino-3-hydroxy-octadecoxy)phosphonic acid Suppliers

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19794-97-9, (2-amino-3-hydroxy-octadecoxy)phosphonic acidRelated Search:

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(2-amino-3-hydroxy-octadecoxy)phosphonic acid

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(2S,3R)-Sphinganine 1-Phosphate

[R-(R*,S*)]-2-AMino-1,3-octadecanediol 1-(Dihydrogen Phosphate)

C18-Dihydrosphingosine 1-Phosphate

Sphinganine-1-phosphate (d18:0)

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2S-amino-1

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<sc>D</sc>-<i>erythro</i>-Dihydrosphingosine 1-phosphate

19794-97-9