Glutathione Ethyl Ester
- Product Name
- Glutathione Ethyl Ester
- CAS No.
- 92614-59-0
- Chemical Name
- Glutathione Ethyl Ester
- Synonyms
- GSH monoethylester;H-γGlu-Cys-Gly-OEt;L-αGlu-L-Cys-Gly-OEt;H-GLU(CYS-GLY-OET)-OH;Glutathione Ethyl Ester;L-αGlu-L-Cys-Gly-Ethyl OH;γ-Glu-Cys-Gly-OEt, GSH-MEE;GLUTATHIONE MON ETHYL ESTER;Glutatione Reduced Ethyl Ester;GLUTATHIONE REDUCED FORM, ETHYL ESTE
- CBNumber
- CB12130580
- Molecular Formula
- C12H21N3O6S
- Formula Weight
- 335.38
- MOL File
- 92614-59-0.mol
Glutathione Ethyl Ester Property
- Boiling point:
- 644.3±55.0 °C(Predicted)
- Density
- 1.314±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- PBS (pH 7.2): 10 mg/ml; Water: 20 mg/ml
- form
- A crystalline solid
- pka
- 2.21±0.10(Predicted)
- color
- White to off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- G1404
- Product name
- Glutathione reduced ethyl ester
- Purity
- ≥90% (TLC)
- Packaging
- 25mg
- Price
- $85.7
- Updated
- 2025/07/31
- Product number
- G1404
- Product name
- Glutathione reduced ethyl ester
- Purity
- ≥90% (TLC)
- Packaging
- 100mg
- Price
- $252
- Updated
- 2025/07/31
- Product number
- 14953
- Product name
- Glutathione ethyl ester
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 14953
- Product name
- Glutathione ethyl ester
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $95
- Updated
- 2024/03/01
- Product number
- 14953
- Product name
- Glutathione ethyl ester
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $350
- Updated
- 2024/03/01
Glutathione Ethyl Ester Chemical Properties,Usage,Production
Description
Glutathione (GSH) serves as a nucleophilic co-
Uses
Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH ethyl ester is a cell permeable derivative of GSH that undergoes hydrolysis by intracellular esterases to release GSH. Effective transport of GSH ethyl ester has been used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals.
Uses
Glutathione reduced ethyl ester has been used:
- to increase intracellular glutathione levels in mouse fibroblast L929 cells
- as a medium supplement in Spodoptera frugiperda (Sf)9 cells
- to evaluate its effect on lipid peroxidation after spinal cord injury
Biochem/physiol Actions
Glutathione reduced ethyl ester (GSH-MEE) is a membrane/lipid permeable derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion. GSH-MEE is hydrolysed by intracellular esterases to release GSH, thereby increases the concentrations of intracellular GSH. It prevents the toxic effects of acetaminophen in animal cells. It protects human lymphoid cells and skin fibroblasts against the damage caused due to radiation.
in vivo
Glutathione ethyl ester (6 mmol/kg; intraperitoneal injection; once; administered 1 h before the experiment) increases the swimming endurance and reduces exercise-induced muscle lipid peroxidation in mice starved for 24 h. However, it has certain metabolic and oxidative stress side effects on the kidney[2]. X
| Animal Model: | Male Swiss-Webster mice (age 2 mo, body wt 25-30 g), a model of exercise-induced oxidative stress[2]. |
| Dosage: | 6 mmol/kg (saline) |
| Administration: | Intraperitoneal injection, once, 1 h before the experiment. |
| Result: | Normalized endurance performance in starved mice. Decreased muscle GSH content and the GSH:GSSG ratio. Also significantly increased endurance time and suppressed exercise-induced muscle lipid peroxidation . |
Glutathione Ethyl Ester Preparation Products And Raw materials
Raw materials
Preparation Products
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