Chemical Properties Background natural source Health Benefits Uses Side effects References
ChemicalBook > CAS DataBase List > Choline bitartrate

Choline bitartrate

Chemical Properties Background natural source Health Benefits Uses Side effects References
Product Name
Choline bitartrate
CAS No.
87-67-2
Chemical Name
Choline bitartrate
Synonyms
CHOLINE BITARTRATE COATED;CHOLINE TARTRATE;CHOLINE HYDROGEN TARTRATE;2-Hydroxy-N,N,N-trimethylethanaminium 3-carboxy-2,3-dihydroxypropanoate;Choline Bitrate;CHOLINE BITARATE;CHOLINE BITARTRATE;Cholini Bitatratis;tanedioicacid(1:1);L-tartrate choline
CBNumber
CB1216550
Molecular Formula
C9H19NO7
Formula Weight
253.25
MOL File
87-67-2.mol
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Choline bitartrate Property

Melting point:
151-153°C
alpha 
[α]D20 +15～+18° (c=4, H2O)
Boiling point:
399.3 °C
Density 
1.47 g/cm3
Flash point:
209.4 °C
storage temp. 
Store at RT.
solubility 
DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
form 
Solid
color 
White to Off-White
Odor
odorless or lt. trimethylamine odor
PH
3.0-4.4 (50g/l, H2O, 20°C)
Water Solubility 
Soluble in alcohol and slightly soluble in water.
Sensitive 
Hygroscopic
InChIKey
QWJSAWXRUVVRLH-UHFFFAOYSA-M
LogP
-1.426 (est)
CAS DataBase Reference
87-67-2(CAS DataBase Reference)
EPA Substance Registry System
Choline tartrate (1:1) (87-67-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
TSCA 
Yes
HS Code 
29231000
Hazardous Substances Data
87-67-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C1629
Product name
Choline bitartrate
Packaging
100g
Price
$64.7
Updated
2025/07/31
Sigma-Aldrich
Product number
1133536
Product name
Choline Bitartrate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$369
Updated
2025/07/31
Sigma-Aldrich
Product number
5.00115
Product name
Choline hydrogen tartrate
Purity
EMPROVE? ESSENTIAL DAB 10,FCC
Packaging
5kg
Price
$692
Updated
2022/05/15
Sigma-Aldrich
Product number
5.00115
Product name
Choline hydrogen tartrate
Purity
EMPROVE? ESSENTIAL DAB 10,FCC
Packaging
25kg
Price
$2396
Updated
2022/05/15
TCI Chemical
Product number
C0553
Product name
Choline Bitartrate
Purity
>98.0%(T)
Packaging
25g
Price
$21
Updated
2025/07/31
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Choline bitartrate Chemical Properties,Usage,Production

Chemical Properties

Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
Choline Bitartrate (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family.
The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body.

Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons.

Background

Choline, a quaternary ammonium compound, is similar to the B vitamins.  It can be made in the liver and found in foods such as liver, muscle meats, fish, nuts, beans, peas, spinach, wheat germ, and eggs. Choline is required to make essential membrane phospholipids. It is an important source of labile methyl groups and a precursor for the biosynthesis of the neurotransmitter acetylcholine which is released by nerve cells to send signals to other cells. Choline is an essential nutrient for humans when excess methionine and folate are not available in the diet. It is used to treat liver diseases, including chronic hepatitis and cirrhosis. It is also used to treat depression, memory loss, Alzheimer-type dementias, Huntington's chorea, Tourette's disease, a brain disorder called cerebellar ataxia, certain types of seizures, and a mental condition called schizophrenia. Athletes use choline for bodybuilding and delaying fatigue in endurance sports. Choline is taken by pregnant women to prevent neural tube defects in their babies and is used as a supplement in infant formulas. Other uses include preventing cancer, lowering cholesterol, and controlling asthma. Choline is often linked together with tartaric acid (also known as bitrate) in many brain vitamin supplement formulas to improve its absorption rate into the body’s nervous system and eventually into the brain. A binding of these two brain vitamins together helps to synthesize compounds that are essential for the optimal health of membranes and nerve endings found in cells in the body.

natural source

natural source of Choline bitartrate: Egg yolk, peanuts, wheat germ, organ meats and legumes.

Health Benefits

Health Benefits of Choline Bitartrate:
Being a product of vitamin, it can be applied to medicine, healthcare product and food.
Choline Bitartrate is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
Influence muscle contractions, movement, coordination and enhance memory.
Involved in higher level brain functions like memory, thought and intellect.
Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
Aid in the treatment of Alzheimer's Disease, manic depression and improve the symptoms of Parkinson's Disease.
Recommended Choline Bitartrate dosage is 500 mg to 3000 mg per day.

Uses

Choline is available as a dietary supplement such as choline chloride or choline bitartrate and lecithin, which usually contains approximately 25 percent phosphatidylcholine or 3 to 4 percent choline by weight. Choline bitartrate and choline chloride are GRAS for use as a nutrient/dietary supplement in animal feed (21 CFR 582.5250, 21 CFR 582.5252). Water-soluble choline salts choline chloride and choline bitartrate are very easily added to virtually any processed food or feed product, liquid, tablet or capsule. They have a long history of safe use and a minimal environmental impact in manufacture and use. Choline chloride could be used as a medicine, dietary supplement, or nutrient. Choline chloride and choline bitartrate deliver a greater bioavailable cation content (74 and 40%, respectively) than do naturally‐occuring forms (e.g. phosphatidylcholine, soybean meal, etc.), and they exhibit excellent stability and high bioavailability in virtually all applications.

Side effects

Choline Bitartrate may be a useful dietary supplement for individuals wishing to increase their daily choline intake.
Choline and Phosphatidylcholine are well tolerated and extremely non-toxic.
Phosphatidylcholine supplementation can worsen depression in some cases.
At higher dosages, Phosphatidylcholine may cause reduced appetite, nausea, abdominal bloating, gastrointestinal pain, and diarrhea. Choline at high dosages (i.e. 20 gms) produces a fish odor.
Choline bitartrate and Choline chloride are also generally recognized as safe forms of Choline supplementation.
Choline is generally regarded as safe and appears to be well-tolerated. High intake of choline may cause low blood pressure, steatorrhea (undigested fat in stool), nausea, vomiting, salivation, diarrhea, constipation, anorexia, dizziness (vertigo), sweating, incomnia and headache. Choline can possibly trigger existing epilepsy. Dosages at the upper limit (UL) intake levels are contraindicated for person suffering from trimethylaminuria, Parkinson's disease, or kidney or liver disease.

References

[1] http://www.brain-smart.net/brain-vitamins-101-what-is-choline-bitartrate/#axzz4eEBgGnNP
[2] S. H. Zeisel, K. A. Da Costa, P. D. Franklin, E. A. Alexander, J. T. Lamont, N. F. Sheard, A. Beiser (1991) Choline, an essential nutrient for humans, 5, 2093-2098

Description

Choline bitartrate is a small molecular weight quaternary amine salt that readily dissociates in water. The benefit of choline salts is the rapid dissolution and availability in the body as free choline as opposed to bound forms, which need to go through several enzymatic steps before the availability of free choline. Choline bitartrate is used in many products, from infant formula to dietary supplements and fortified foods. It dissolves rapidly in the digestive system, providing the free choline needed to meet choline demands.

Chemical Properties

White cryst. powder

Biological Functions

Choline Bitartrate is used by nerve cells to manufacture a chemical called acetylcholine, which effectively allows cells to communicate with each other. Choline is also heavily associated with neurological function and can help improve movement, coordination, and myofibril contraction.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Acyl group acceptor

Choline bitartrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Choline bitartrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Choline bitartrate 87-67-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
500kg/month
Release date
2021-07-23
Hebei Chuanghai Biotechnology Co., Ltd
Product
Choline bitartrate 87-67-2
Price
US $25.00/ASSAYS
Min. Order
100ASSAYS
Purity
99.5%
Supply Ability
100 mt
Release date
2024-11-20
HebeiShuoshengImportandExportco.,Ltd
Product
Choline bitartrate 87-67-2
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-05

87-67-2, Choline bitartrateRelated Search:

Choline chloride Kitasamycin tartrate Choline hydroxide Metoprolol tartrate Potassium Bitartrate L-Carnitine-L-tartrate Metaraminol bitartrate L(+)-Tartaric acid D(-)-Tartaric acid 2-(METHYLSULFONYL)ETHANOL Epinephrine bitartrate (-)-Phenylephrine hydrogentartrate Rivastigmine tartrate Pyridinium dichromate Norepinephrine Bitartrate Choline Bitartrate Tetramethylammonium acetate Tetramethylammonium hydroxide pentahydrate

  • CHOLINE BITARTRATE
  • CHOLINE BITARTRATE SALT
  • CHOLINE HYDROGEN TARTRATE
  • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with (2R,3R)-2,3-dihydroxybutanedioic acid (1:1)
  • CHOLINE BITARTRATE COATED
  • CHOLINE BITARTRATE UNCOATED
  • Cholini Bitatratis
  • 2-Hydroxyethyl-trimethylazanium (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate
  • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with [R-(R*,R*)]-2,3-dihydroxybutanedioic acid (1:1)
  • (2R,3R)-2,3,4-trihydroxy-4-keto-butyrate
  • (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate
  • (2R,3R)-2,3,4-trihydroxy-4-oxo-butanoate
  • Choline bitartrate,2-(Hydroxyethyl)trimethylammonium bitartrate
  • Choline bitartrate, synthesis grade
  • Choline Bitartrate (200 mg)
  • Choline Hydrogen L-(+)-Tartrate
  • Choline Bitrate
  • 2-Hydroxy-N,N,N-trimethylethanaminium 3-carboxy-2,3-dihydroxypropanoate
  • Tartaric acid choline
  • Choline bitartrate in stock Factory
  • CHOLINE TARTRATE
  • (2-HYDROXYETHYL)TRIMETHYLAMMONIUM BITARTRATE
  • [2-HYDROXYETHYL]TRIMETHYLAMMONIUM BITARTRATE SALT
  • 3-dihydroxybutanedioicacid(1:1)
  • choline,tartrate(1:1)salt
  • ethanaminium,2-hydroxy-n,n,n-trimethyl-,saltwith(r-(r+,r+))-2,3-dihydroxybu
  • ethanaminium,2-hydroxy-n,n,n-trimethyl-,saltwith[theta-(theta,theta)]-2,
  • tanedioicacid(1:1)
  • choline bitartrate cell culture tested
  • choline bitartrate crystalline
  • Cholinebitartrate,98%
  • Choline L-(+)-Bitartrate
  • Choline BitartrateUSP/FCC, Coated
  • Choline BitartrateUSP/FCC, Uncoated
  • Choline Bitartrate &gt
  • 2,3,4-trihydroxy-4-oxobutanoate
  • Citicoline Impurity 9
  • Choline bitartrate solution in Methanol，1000μg/mL
  • Choline bitartrate USP/EP/BP
  • CHOLINE BITARATE
  • CHOLINE BITARTRATE Extra Pure
  • Choline Bitartrate (1133536)
  • 2-Hydroxy-N,N,N-trimethylethan-1-aminium (2R,3R)-3-carboxy-2,3-dihydroxypropanoate
  • L-(+)-Choline Bitartrate Uncoated
  • Choline tartrate (6CI)
  • L-acetylcholine tartrate
  • Choline Bitartrate Sulfate
  • Choline bitartrate, 10 mM in DMSO
  • L-tartrate choline
  • 87-67-2
  • C5H14NOC4H5O6
  • C9H19NO7
  • C5H14NOC4H5O6C9H19NO7
  • C5H14NOC4H5O6C9H19NO
  • Quaternary Ammonium Compounds
  • Ammonium Polyhalides, etc. (Quaternary)
  • Food additive and acidulant
  • Ammonium Polyhalides, etc. (Quaternary)