ChemicalBook > CAS DataBase List > (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol

(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol

Appearance

Product Name: (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol
CAS No.: 88930-15-8
Chemical Name: (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol
Synonyms: Mogrol;Mogrol-RM;Mogrol, >98%;Monascus alcohol;Mogrol, 10 mM in DMSO;(24R)-Cucurbit-5-ene-3β,11α,24,25-tetrol;(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol;(10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene;ERK,inhibit,Extracellular signal regulated kinases,STAT,Mogrol,Inhibitor;(3S,8S,9R,10R,11R,13R,14S,17R)-17-((2R,5R)-5,6-Dihydroxy-6-methylheptan-2-yl)-4,4,9,13,14-pentamethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,11-diol
CBNumber: CB12165711
Molecular Formula: C30H52O4
Formula Weight: 476.73
MOL File: 88930-15-8.mol

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(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Property

Boiling point:: 595.6±50.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 14.67±0.29(Predicted)
color: White to off-white
InChIKey: JLYBBRAAICDTIS-AYEHCKLZSA-N
CAS DataBase Reference: 88930-15-8

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL84241
Product name: Mogrol
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $555
Updated: 2025/07/31

ChemScene

Product number: CS-6010
Product name: Mogrol
Purity: 98.06%
Packaging: 1mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-6010
Product name: Mogrol
Purity: 98.06%
Packaging: 5mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-6010
Product name: Mogrol
Purity: 98.06%
Packaging: 10mg
Price: $320
Updated: 2021/12/16

ChemScene

Product number: CS-6010
Product name: Mogrol
Purity: 98.06%
Packaging: 25mg
Price: $640
Updated: 2021/12/16

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(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Chemical Properties,Usage,Production

Appearance

Constit. of Cucurbita foeridissimia (buffalo gourd).Amorph. powder.

Chemical Properties

Off-white powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Momordica grosvenori.

Uses

Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

Definition

ChEBI: Mogrol is a tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii. It has a role as an antineoplastic agent. It is a tetracyclic triterpenoid and a hydroxy seco-steroid. It is functionally related to a cucurbitadienol.

Biochem/physiol Actions

Mogrol is an aglycone of mogrosides from Siraitia grosvenorii that exhibits neuroprotective and anticancer activities. It induces apoptosis in K562 leukemia cells through suppression of ERK1/2 and STAT3 pathways. Mogrol appears to ameliorate the memory impairment caused by Aβ1-42 in mice. Mogrol increases AMPK activity in hepatocytes and suppresses adipocyte differentiation in 3T3-L1 cells.

IC 50

ERK1; ERK2; STAT3

References

[1] Liu C, et al. Mogrol represents a novel leukemia therapeutic, via ERK and STAT3 inhibition. Am J Cancer Res. 2015 Mar 15;5(4):1308-18.
[2] Naoki Harada, et al. Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation. PLoS One. 2

(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Mogrol 88930-15-8
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-25

88930-15-8, (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrolRelated Search:

Crotonic acid Mogroside III A2 Neomogroside MOGROSIDE III Mogroside ⅢA1 Mogroside II B Mogroside I A1 mogroside IV Mogroside II A1 MogrosideIIE Siamenoside I Mogroside IVa Mogroside Ⅲe 11-Oxomogroside I Mogroside V MOGROSIDE IV isoMogroside V Mogroside I E1

(10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene

(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol

(24R)-Cucurbit-5-ene-3β,11α,24,25-tetrol

Mogrol

Mogrol, >98%

ERK,inhibit,Extracellular signal regulated kinases,STAT,Mogrol,Inhibitor

Monascus alcohol

Mogrol-RM

Mogrol, 10 mM in DMSO

(3S,8S,9R,10R,11R,13R,14S,17R)-17-((2R,5R)-5,6-Dihydroxy-6-methylheptan-2-yl)-4,4,9,13,14-pentamethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,11-diol

88930-15-8