ChemicalBook > CAS DataBase List > (R)-2-Phenyl-3-methylbutanoic acid
(R)-2-Phenyl-3-methylbutanoic acid
- Product Name
- (R)-2-Phenyl-3-methylbutanoic acid
- CAS No.
- 13491-13-9
- Chemical Name
- (R)-2-Phenyl-3-methylbutanoic acid
- Synonyms
- (R)-3-Methyl-2-phenylbutanoic acid;(R)-2-Phenyl-3-methylbutanoic acid;[R,(-)]-3-Methyl-2-phenylbutyric acid;(aR)-alpha-(1-Methylethyl)-benzeneacetic acid;Benzeneacetic acid, α-(1-methylethyl)-, (αR)-;(alphaR)-alpha-(1-Methylethyl)benzeneacetic acid;Benzeneacetic acid, .alpha.-(1-methylethyl)-, (.alpha.R)-
- CBNumber
- CB12191237
- Molecular Formula
- C11H14O2
- Formula Weight
- 178.23
- MOL File
- 13491-13-9.mol
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(R)-2-Phenyl-3-methylbutanoic acid Property
- Density
- 1.063
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
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N-Bromosuccinimide Price
AK Scientific
- Product number
- 6254AA
- Product name
- (R)-3-Methyl-2-phenylbutanoicacid
- Packaging
- 250mg
- Price
- $162
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CCH0034478
- Product name
- (R)-3-METHYL-2-PHENYLBUTANOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $433.65
- Updated
- 2021/12/16
ACHEMBLOCK
- Product number
- O34364
- Product name
- (R)-3-Methyl-2-phenyl-butyricacid
- Purity
- 95%
- Packaging
- 5G
- Price
- $495
- Updated
- 2021/12/16
Ambeed
- Product number
- A118938
- Product name
- (R)-3-Methyl-2-phenylbutanoicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $665
- Updated
- 2021/12/16
Acrotein
- Product number
- UT01748
- Product name
- (R)-3-Methyl-2-phenyl-butyricacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $819.49
- Updated
- 2021/12/16
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(R)-2-Phenyl-3-methylbutanoic acid Chemical Properties,Usage,Production
Synthesis
3508-94-9
13491-13-9
General procedure for the synthesis of (R)-3-methyl-2-phenylbutyric acid from 3-methyl-2-phenylbutyric acid: 2-isopropylphenylacetic acid (8.91 g), (+)-α-phenylethylamine (6.45 mL), and 63% aqueous ethanol (193 mL) were mixed, and the reaction was slowed and cooled by reflux. The resulting salt was purified by three recrystallizations from 63% aqueous ethanol solution. Subsequently, the salt was treated with 10% sulfuric acid at 0 °C, the reaction mixture was extracted with ethyl acetate, and the organic phase was dried and concentrated to give 3.52 g of (R)-(-)-2-isopropylphenylacetic acid in 39% yield, [α]25D -58.6° (CHCl3, c = 0.02).
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 140, p. 42 - 51
[2] Chemical Communications, 2006, # 34, p. 3600 - 3602
(R)-2-Phenyl-3-methylbutanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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