N-Methylleukotriene C4
- Product Name
- N-Methylleukotriene C4
- CAS No.
- 131391-65-6
- Chemical Name
- N-Methylleukotriene C4
- Synonyms
- NMLTC4;N-METHYL LTC4;N-Methylleukotriene C4;FPLBRCJNODNRQZ-UYCXAPQFSA-N;N methyl Leukotriene C4,N-methyl Leukotriene C-4,Nmethyl Leukotriene C4;Glycine, N-methyl-L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteinyl-;N-[S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-N-(L-γ-glutamyl)-L-cysteinyl]-N-methylglycine
- CBNumber
- CB12192012
- Molecular Formula
- C31H49N3O9S
- Formula Weight
- 639.81
- MOL File
- 131391-65-6.mol
N-Methylleukotriene C4 Property
- Boiling point:
- 965.7±65.0 °C(Predicted)
- Density
- 1.202±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; Ethanol:H20 (95:5): 2 mg/ml; PBS (pH 7.2): 100 μg/ml
- pka
- 2.23±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 13390
- Product name
- N-methyl Leukotriene C4
- Purity
- ≥97%
- Packaging
- 25μg
- Price
- $165
- Updated
- 2024/03/01
- Product number
- 13390
- Product name
- N-methyl Leukotriene C4
- Purity
- ≥97%
- Packaging
- 50μg
- Price
- $313
- Updated
- 2024/03/01
- Product number
- 13390
- Product name
- N-methyl Leukotriene C4
- Purity
- ≥97%
- Packaging
- 100μg
- Price
- $592
- Updated
- 2024/03/01
- Product number
- L330388
- Product name
- N-methylLeukotrieneC4
- Packaging
- 2.5mg
- Price
- $1235
- Updated
- 2021/12/16
N-Methylleukotriene C4 Chemical Properties,Usage,Production
Uses
Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.
Uses
N-methyl Leukotriene C4 is synthetic analog of LTC4 with decreased binding affinity.
N-Methylleukotriene C4 Preparation Products And Raw materials
Raw materials
Preparation Products
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