ChemicalBook > CAS DataBase List > (R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER

(R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER

Product Name
(R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER
CAS No.
88496-70-2
Chemical Name
(R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER
Synonyms
(R)-4-CHLORO-3-HYDROXYBUTYRATE;(R)-Methyl-4-cloro-3-hydroxybut;(R)-Methyl-4-cloro-3-hydroxybutyrate;(R)-METHYL 4-CHLORO-3-HYDROXYBUTYRATE;METHYL (R)-4-CHLORO-3-HYDROXYBUTYRATE;(R)-Methyl 4-chloro-3-hydroxybutanoate;Methyl (R)-4-Chloro-3-hydroxybutanoate;Methyl(R)-4-Chloro-3-hydroxybutyrate>(R)-4-Chloro-3-hydroxybutyric acid methyl;Methyl (R)-4-Chloro-3-hydroxybutyrate
CBNumber
CB1220490
Molecular Formula
C5H9ClO3
Formula Weight
152.58
MOL File
88496-70-2.mol
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(R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER Property

Boiling point:
248.6±20.0 °C(Predicted)
Density 
1.232±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
12.73±0.20(Predicted)
CAS DataBase Reference
88496-70-2(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36
HS Code 
2918199890
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C381785
Product name
(R)-4-Chloro-3-hydroxybutyricAcidMethylEster
Packaging
50mg
Price
$60
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0009354
Product name
(R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER
Purity
95.00%
Packaging
1G
Price
$619.7
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0009354
Product name
(R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER
Purity
95.00%
Packaging
2.5G
Price
$796.77
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0009354
Product name
(R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER
Purity
95.00%
Packaging
5G
Price
$912.29
Updated
2021/12/16
Matrix Scientific
Product number
095812
Product name
(R)-Methyl 4-chloro-3-hydroxybutanoate
Purity
95+%
Packaging
5g
Price
$168
Updated
2021/12/16
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(R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Synthesis

114819-45-3

88496-70-2

The general procedure for the synthesis of (R)-4-chloro-3-hydroxybutanoic acid methyl ester from the compound (CAS:114819-45-3) is as follows: to a solution of (R)-3-hydroxybutanoic acid methyl ester (125.1 g, 0.93 mol) in methylene chloride (1.8 L) was added triphenylphosphine (244.5 g, 0.93 mol), and under cooling in an ice-water bath, the N- chlorosuccinimide (124.2 g, 0.93 mol) was added slowly under cooling in an ice water bath. The reaction mixture was stirred at 5 °C for 20 min, followed by continued stirring at room temperature for 18 h. The reaction was carried out at room temperature. Upon completion of the reaction, the solvent was removed by evaporation and the residue was purified by column chromatography (petroleum ether/ethyl acetate, 20:1 to 5:1, gradient elution) to afford the target product (R)-methyl (R)-4-chloro-3-hydroxybutanoate (33 g, three-step overall yield 26%). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 4.18-4.25 (m, 1H), 3.68 (s, 3H), 3.55-3.60 (m, 2H), 3.32-3.33 (d, J = 4.2 Hz, 1H), 2.52-2.68 (m, 2H).

References

[1] Patent: WO2007/21982, 2007, A2. Location in patent: Page/Page column 67-68

(R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER Suppliers

Canada 1 China 72 Germany 1 India 3 Japan 3 United Kingdom 9 United States 21 Global 110
Alchem Pharmtech,Inc.
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View Lastest Price from (R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
(R)-4-Chloro-3-hydroxybutyric acid methyl ester 88496-70-2
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-24
Zhuozhou Wenxi import and Export Co., Ltd
Product
(R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER 88496-70-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
(R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER 88496-70-2
Price
US $0.01/KG
Min. Order
500g
Purity
98%; 99%
Supply Ability
500g；1kg； 10kg; 25kg
Release date
2020-01-08

88496-70-2, (R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTERRelated Search:

3-Hydroxybutyric acid Methyl 4-chloro-3-hydroxybutyrate (R)-4-CHLORO-1,3-BUTANEDIOL Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate Methyl 4-chlorobutyrate 4-Chloro-3-hydroxy-butyricacidmethylester (R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER

  • (R)-Methyl-4-cloro-3-hydroxybutyrate
  • METHYL (R)-4-CHLORO-3-HYDROXYBUTYRATE
  • (R)-METHYL 4-CHLORO-3-HYDROXYBUTYRATE
  • (R)-(+)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER
  • (R)-4-CHLORO-3-HYDROXYBUTYRIC ACID METHYL ESTER
  • Methyl (<i>R</i>)-4-Chloro-3-hydroxybutyrate
  • (R/S)4-Chloro-3-hydroxybutyric Acid Methyl ester
  • (R)-Methyl 4-chloro-3-hydroxybutanoate
  • (R)-4-Chloro-3-hydroxybutyric acid methyl
  • (R)-4-CHLORO-3-HYDROXYBUTYRATE
  • (R)-Methyl-4-cloro-3-hydroxybut
  • Methyl(R)-4-Chloro-3-hydroxybutyrate&gt
  • Butanoic acid, 4-chloro-3-hydroxy-, methyl ester, (3R)-
  • Methyl (R)-4-Chloro-3-hydroxybutanoate
  • 88496-70-2
  • Chiral Building Blocks
  • Simple Alcohols (Chiral)
  • Chiral Building Blocks
  • Simple Alcohols (Chiral)
  • Synthetic Organic Chemistry
  • Chiral Compound