6-BROMO-4-IODOQUINOLINE
- Product Name
- 6-BROMO-4-IODOQUINOLINE
- CAS No.
- 927801-23-8
- Chemical Name
- 6-BROMO-4-IODOQUINOLINE
- Synonyms
- 6-BROMO-4-IODOQUINOLINE;4-Iodo-6-bromoquinoline;Quinoline, 6-bromo-4-iodo-;6-Bromo-4-iodoquinoline 97%
- CBNumber
- CB1222641
- Molecular Formula
- C9H5BrIN
- Formula Weight
- 333.95
- MOL File
- Mol file
6-BROMO-4-IODOQUINOLINE Property
- Boiling point:
- 375.5±22.0 °C(Predicted)
- Density
- 2.154±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- solid
- pka
- 2.77±0.16(Predicted)
- color
- Brown
- InChI
- InChI=1S/C9H5BrIN/c10-6-1-2-9-7(5-6)8(11)3-4-12-9/h1-5H
- InChIKey
- BWFLFNVNIISPPK-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(Br)=CC=2)C(I)=CC=1
Safety
- HS Code
- 2933491090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B693718
- Product name
- 6-Bromo-4-iodoquinoline
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR927338
- Product name
- 6-Bromo-4-iodoquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $91
- Updated
- 2021/12/16
- Product number
- FB142388
- Product name
- 6-Bromo-4-iodoquinoline
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- OR927338
- Product name
- 6-Bromo-4-iodoquinoline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 3H32-S-0B
- Product name
- 6-Bromo-4-iodoquinoline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $52
- Updated
- 2021/12/16
6-BROMO-4-IODOQUINOLINE Chemical Properties,Usage,Production
Synthesis
1086062-75-0
927801-23-8
4.1.9 Synthesis of 6-bromo-4-iodoquinoline (12): To an anhydrous ethyl acetate (20 mL) solution of 6-bromo-4-chloroquinoline (11) (3.50 g, 14.46 mmol) was added hydrochloric acid saturated ethyl acetate (40 mL), and the formation of a white precipitate was immediately observed. After stirring for 30 min, the suspension was concentrated under vacuum to give 6-bromo-4-chloroquinoline hydrochloride as an off-white solid (3.91 g, 14.14 mmol). Subsequently, 6-bromo-4-chloroquinoline hydrochloride (3.91 g, 14.14 mmol), anhydrous potassium iodide (9.76 g, 70.70 mmol), and anhydrous acetonitrile (100 mL) were added in a two-neck flask. The resulting slurry was stirred under reflux conditions for 48 hours and then cooled to room temperature. The reaction mixture was treated with saturated aqueous sodium bicarbonate solution (40 mL) and 5% sodium sulfite solution (20 mL). The reaction mixture was extracted with dichloromethane (200 mL x 2), and the combined organic phases were dried over magnesium sulfate and concentrated under vacuum to give the crude product. The crude product was further purified by silica gel column chromatography (25% ethyl acetate/petroleum ether) to afford the target compound 6-bromo-4-iodoquinoline (4.42 g, 13.27 mmol, 94% yield) as an off-white solid. 1H NMR (500 MHz, DMSO-d6) δ 8.51 (d, J = 4.5 Hz, 1H, Ar-H), 8.21 (d, J = 4.5 Hz, 1H, Ar-H), 8.11 (t, J = 1.5 Hz, 1H, Ar-H), 7.97-7.91 (m, 2H, Ar-H). ESI-MS: m/z = 334 [M + H]+.
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 99, p. 36 - 50
[2] RSC Advances, 2017, vol. 7, # 4, p. 2342 - 2350
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 4, p. 1569 - 1574
[4] Patent: WO2014/22128, 2014, A1. Location in patent: Paragraph 0156; 0157
[5] Patent: CN103539777, 2016, B. Location in patent: Paragraph 0276; 0327; 0328
6-BROMO-4-IODOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-BROMO-4-IODOQUINOLINE manufacturers
- Product
- 6-BROMO-4-IODOQUINOLINE 927801-23-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02