Toxicity
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2-Bromoethanol

Toxicity
Product Name
2-Bromoethanol
CAS No.
540-51-2
Chemical Name
2-Bromoethanol
Synonyms
bromoethanol;Ethanol, 2-bromo-;2-Bromethanol;DKFELEX0079;BROMOETHANOL-2;2-BROMOETHANOL;2-Bromorthanol;2-bromo-ethano;2-Bromo Ethenol;2-bromo-1-ethanol
CBNumber
CB3853766
Molecular Formula
C2H5BrO
Formula Weight
124.96
MOL File
540-51-2.mol
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2-Bromoethanol Property

Melting point:
-80 °C
Boiling point:
56-57 °C/20 mmHg (lit.)
Density 
1.763 g/mL at 25 °C (lit.)
vapor density 
4.3 (vs air)
vapor pressure 
2.4 mm Hg ( 20 °C)
refractive index 
n20/D 1.492(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
1-5 g/100 mL at 19°C
form 
Liquid
pka
13.82±0.10(Predicted)
color 
Clear colorless to yellow
Specific Gravity
1.7629 (20/4℃)
Water Solubility 
1-5 g/100 mL at 19 ºC
Sensitive 
Light Sensitive
Merck 
14,3792
BRN 
878140
Stability:
Stable, but probably light sensitive. Hygroscopic. Incompatible with strong oxidizing agents. Flammable. Forms an azeotrope with water.
InChIKey
LDLCZOVUSADOIV-UHFFFAOYSA-N
CAS DataBase Reference
540-51-2(CAS DataBase Reference)
NIST Chemistry Reference
Ethanol, 2-bromo-(540-51-2)
EPA Substance Registry System
2-Bromoethanol (540-51-2)
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Safety

Hazard Codes 
T,T+,Xn,F
Risk Statements 
23/24/25-34-40-36/37/38-26/27/28-10-67-65-48/20-38-11-63
Safety Statements 
26-36/37/39-45-28A-16-62-36/37
RIDADR 
UN 2922 8/PG 2
WGK Germany 
3
RTECS 
KJ8225000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29055900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B65586
Product name
2-Bromoethanol
Purity
95%
Packaging
5g
Price
$55
Updated
2024/03/01
Sigma-Aldrich
Product number
B65586
Product name
2-Bromoethanol
Purity
95%
Packaging
100g
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
48874
Product name
2-Bromoethanol solution
Purity
certified reference material, 2000?μg/mL in toluene
Packaging
1ML
Price
$52.6
Updated
2024/03/01
Sigma-Aldrich
Product number
442334
Product name
2-Bromoethanol
Purity
analytical standard
Packaging
1000mg
Price
$36.9
Updated
2024/03/01
TCI Chemical
Product number
B0590
Product name
2-Bromoethanol
Purity
>95.0%(GC)
Packaging
25g
Price
$22
Updated
2024/03/01
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2-Bromoethanol Chemical Properties,Usage,Production

Toxicity

2-Bromoethanol can damage human body. The invasive ways of 2-bromoethanol include inhalation, ingestion and percutaneous absorption. 2-Bromoethanol has strong irritation to mucosa, upper respiratory tract, eyes and skin. Inhalation of 2-bromoethanol can cause death due to spasm, inflammation and edema of larynx and bronchus, chemical pneumonia and pulmonary edema. The manifestations of 2-bromoethanol poisoning include burning sensation, cough, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting.

Description

2-bromoethanol, a halogenated alipathic hydrocarbon, is a widely used industrial chemical. It is also a contaminant in food such as wheat and flour during treatment with ethylene oxide. 2-Bromoethanol was also found as a metabolite of 1,2-dibromoethane. A known carcinogen in experimental animals. 2-Bromoethanol is highly toxic in vivo and is a potent mutagen. Fatty acid conjugates of 2-bromoethanol that have been identified after 2-bromoethanol administration to rats may explain the long term 2-bromoethanol accumulation and retention in body tissues. Chronic exposure to 2-bromoethanol causes liver and kidney toxicity. 2- Bromoethanol also induces extensive lipid peroxidation in rat liver, kidney and testis slices and inhibits liver mitochondria respiration[1].

Chemical Properties

2-Bromoethanol is a colorless or light yellow hygroscopic liquid with relatively stable and toxic chemical properties. It plays a role in industrial and chemical experiments. It shall be stored in a ventilated, low-temperature and dry warehouse and separated from oxidants, acids and food additives. It is miscible with water and forms an azeotrope with water. The boiling point is 99.1 ℃ (101.35kpa). The aqueous solution has a sweet burning taste. It can be miscible with most organic solvents such as ethanol and ether, but insoluble in petroleum ether. The hydrolysis of aqueous solution can be accelerated when it meets acid, alkali and heating.

Chemical Properties

colourless liquid

Uses

2-Bromoethanol is used in selective reduction of nitroarenes (PcFe(II)/NaBH4/2-bromoethanol catalyst system). It is not used much forany commercial purpose. The risk of exposure to this compound arises when ethylene oxide reacts with hydrobromic acid. It is used as a solvent and organic synthetic raw material. 2-Bromoethanol finds application in the synthesis of 2-piperidin-1-yl-ethanol by reacting with piperidine.

General Description

Colorless to dark brown liquid. Sweet burning taste.

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

2-Bromoethanol forms an azeotrope with water; hydrolysis of aqueous solutions is accelerated by heat, alkalis and acids.

Hazard

Irritant to eyes and mucous membranes.

Health Hazard

The vapors of ethylene bromohydrin are anirritant to the eyes and mucous membranes.It is corrosive to the skin. Ingestion of thiscompound can produce moderate to severetoxic effects. The target organs are the CNS,gastrointestinal tract, and liver. The lethaldose in mice by the intraperitoneal route was80 mg/kg.
Ethylene bromohydrin manifested car cinogenicity in test animals. It caused tumorsin lungs and the gastrointestinal tract in micefrom intraperitoneal (150 mg/kg/8 weeks)and oral (43 mg/kg/80 weeks) dosages,respectively. It is a mutagen, positive to thehistidine reversion–Ames test.

Fire Hazard

2-Bromoethanol is combustible.

Safety Profile

Poison by intraperitoneal route. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Br-. See also

Synthesis

Ethylene gas is washed and passed into an ice-cold solution of 7.2 g of bromine in 500 ml water. After complete absorption of the bromine, a fresh portion of 7.2 g, equal to the first, is added, with frequent and vigorous agitation, until a total weight of 200 g of bromine has reacted. The lower layer of ethylene dibromide, formed during the process, is separated, washed with water, and dried over sodium sulfate. Yield, 88 g. After neutralizing with the sodium carbonate and saturating the aqueous layer with sodium chloride, the 2-bromoethanol is extracted by shaking twice with 100 ml of ether, dried over sodium sulfate; the ether is removed by evaporation yielding 85 g of bulk of the residual liquid, which distils between 145-149° C. 54.4% of the bromine is converted into 2-bromoethanol and 37.5% into ethylene dibromide. The remainder is found as hydrobromic acid.

Waste Disposal

Ethylene bromohydrin is mixed with a combustible solvent and burned in a chemicalincinerator.

References

[1] Sumsullah Khan, Peter J. O’Brien, Christian Sood. “The Involvement of Cytochrome P4502E1 in 2-Bromoethanol-Induced Hepatocyte Cytotoxicity.” Basic Clinical Pharmacology Toxicology 78 4 (1996): 241–248.
[2] L. Jenneskens, J. Ripoll, U. Wiersum. “Flash vacuum thermolysis of 2-bromoethanol. Formation of α-bromoethylethers via 1-bromoethanol.” Tetrahedron Letters 62 1 (1988): 6489–6491.
[3] L. Homanen, J. Murto. “Infrared-induced rotamerization of 2-bromoethanol and 2-iodoethanol in argon matrices.” Chemical Physics Letters 85 1 (1982): 322–324.

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2-Bromoethanol Suppliers

Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5904
Advantage
65
Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd.
Tel
029-88380327 17691182729
Fax
029-88380327
Email
1018@dideu.com
Country
China
ProdList
1993
Advantage
58
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
15523000485
Email
xingcanyaoye@sina.com
Country
China
ProdList
1687
Advantage
58
Qingdao Dexin Chemical Co., Ltd
Tel
17354621915 17354621915
Email
1214127295@qq.com
Country
China
ProdList
77
Advantage
58
Tongling LishidaChem Technology Co., Ltd
Tel
0186-06623089 18606623089
Email
350737036@qq.com
Country
China
ProdList
125
Advantage
58
CHEMBSF (Shanghai) Biomedical Technology Co., Ltd
Tel
18117346937 18117346937
Email
18117346937@163.com
Country
China
ProdList
5026
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
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View Lastest Price from 2-Bromoethanol manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
2-Bromoethanol 540-51-2
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-27
Hebei Mojin Biotechnology Co., Ltd
Product
2-Bromoethanol 540-51-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-07-21
Handan Tongyi New Material Technology Co., Ltd
Product
2-Bromoethanol 540-51-2
Price
US $1.00/Kg
Min. Order
1KG
Purity
99.9%
Supply Ability
800kgs/month
Release date
2021-03-02

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