Benzyl 2-bromoacetate
- Product Name
- Benzyl 2-bromoacetate
- CAS No.
- 5437-45-6
- Chemical Name
- Benzyl 2-bromoacetate
- Synonyms
- BENZYL BROMOACETATE;merbac35;TIMTEC-BB SBB006752;BENZYL 2-BROMOACETATE;Benzyl a-Bromoacetate;BroMine benzyl acetate;Benzylbromoacetate,97%;Benzyl broMoacetate 96%;Bromoacetic acid benzyl;Benzyl Bromoacetate >
- CBNumber
- CB9413740
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 5437-45-6.mol
Benzyl 2-bromoacetate Property
- Melting point:
- 199-201 °C(Solv: water (7732-18-5))
- Boiling point:
- 166-170 °C22 mm Hg(lit.)
- Density
- 1.446 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.544(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol
- form
- Liquid
- Specific Gravity
- 1.446
- color
- Clear colorless to light yellow
- Water Solubility
- Not miscible or difficult to mix in water.
- BRN
- 973658
- LogP
- 2.368 (est)
- CAS DataBase Reference
- 5437-45-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzyl 2-bromoacetate(5437-45-6)
- EPA Substance Registry System
- Benzyl bromoacetate (5437-45-6)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 245631
- Product name
- Benzyl bromoacetate
- Purity
- 96%
- Packaging
- 50g
- Price
- $42.1
- Updated
- 2025/07/31
- Product number
- 245631
- Product name
- Benzyl bromoacetate
- Purity
- 96%
- Packaging
- 250g
- Price
- $140
- Updated
- 2025/07/31
- Product number
- B1674
- Product name
- Benzyl Bromoacetate
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $22
- Updated
- 2025/07/31
- Product number
- B1674
- Product name
- Benzyl Bromoacetate
- Purity
- >96.0%(GC)
- Packaging
- 500g
- Price
- $194
- Updated
- 2025/07/31
- Product number
- B679115
- Product name
- 2-BromoaceticAcidPhenylmethylEster
- Packaging
- 10g
- Price
- $65
- Updated
- 2021/12/16
Benzyl 2-bromoacetate Chemical Properties,Usage,Production
Chemical Properties
Colorless to light yellow liqui
Uses
It is employed in biological research purpose. Benzyl bromoacetate was used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.
Synthesis
79-08-3
100-51-6
103-50-4
5437-45-6
General method: A mixture of acid 2 (0.033 g), 2-bromoacetic acid (3a) (0.137 g, 0.988 mmol) adsorbed on silica gel and benzyl alcohol (4a) (0.108 g, 1.000 mmol) was stirred and reacted at 80°C for 24 h under argon protection. After completion of the reaction, the mixture was cooled to room temperature, ether (5 mL x 5) was added for extraction, and the organic layer was separated by decantation from the silica gel adsorbed acid 2. The organic layer was concentrated under reduced pressure to remove the solvent, and then purified by silica gel column chromatography to afford benzyl 2-bromoacetate (5aa) (0.189 g, 83% yield) using hexane/ethyl acetate (v/v = 10/1) as eluent. The silica gel adsorbed acid 2 was recovered by vacuum drying at room temperature to give a white powder (0.033 g, 99% recovery).
Purification Methods
Dilute the ester with Et2O, wash it with 10% aqueous NaHCO3, H2O, dry (MgSO4) and fractionate it using a Fenske (glass helices packing) column. [Bergmann & Szinai J Chem Soc 1521 1956, Beilstein 6 IV 2265.] LACHRYMATORY.
References
[1] Journal of Molecular Catalysis A: Chemical, 2013, vol. 367, p. 116 - 120
Benzyl 2-bromoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzyl 2-bromoacetate manufacturers
- Product
- Benzyl 2-bromoacetate 5437-45-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- benzyl bromoacetate 5437-45-6
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-22
- Product
- Benzyl 2-bromoacetate 5437-45-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11