Description Mechanism of Action Precautions
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Aceclofenac

Description Mechanism of Action Precautions
Product Name
Aceclofenac
CAS No.
89796-99-6
Chemical Name
Aceclofenac
Synonyms
Zerodol;Preservex;Gerbin;Falcol;Airtal;PR-82/3;Tresquim;Biofenac;Aceclofar;Acelofenac
CBNumber
CB0402570
Molecular Formula
C16H13Cl2NO4
Formula Weight
354.18
MOL File
89796-99-6.mol
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Aceclofenac Property

Melting point:
149-153°C
Boiling point:
486.0±45.0 °C(Predicted)
Density 
1.455±0.06 g/cm3(Predicted)
RTECS 
CY1577900
storage temp. 
2-8°C
solubility 
Soluble in DMSO
form 
powder
pka
2.60±0.10(Predicted)
color 
off-white to light tan
Water Solubility 
32mg/L(32 ºC)
Merck 
14,22
InChIKey
MNIPYSSQXLZQLJ-UHFFFAOYSA-N
CAS DataBase Reference
89796-99-6(CAS DataBase Reference)
EPA Substance Registry System
Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, carboxymethyl ester (89796-99-6)
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Safety

Hazard Codes 
T,N
Risk Statements 
25-36-50/53
Safety Statements 
26-45-60-61
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A8861
Product name
Aceclofenac
Purity
≥98% (HPLC)
Packaging
10mg
Price
$31.12
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR3166
Product name
Aceclofenac
Purity
pharmaceutical secondary standard, certified reference material
Packaging
100MG
Price
$668
Updated
2024/03/01
Sigma-Aldrich
Product number
A8861
Product name
Aceclofenac
Purity
≥98% (HPLC)
Packaging
50mg
Price
$300
Updated
2024/03/01
TCI Chemical
Product number
A2484
Product name
Aceclofenac
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
A2484
Product name
Aceclofenac
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$42
Updated
2024/03/01
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Aceclofenac Chemical Properties,Usage,Production

Description

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAIDs) that is commonly prescribed for people with painful rheumatic conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
The drug should not be given to children, breastfeeding mothers, and people with porphyria. Pregnant women should not also be given aceclofenac as they risk developing patent ductus arteriosus in the neonate.

Mechanism of Action

Aceclofenac acts by inhibiting the effect of natural substances known as cyclooxygenase (COX) enzymes. Notably, these enzymes are responsible for making other chemicals in the body, namely prostaglandins. The prostaglandins are normally produced at sites of damages or injury cause inflammation and pain. By blocking the influence of COX enzymes, production of prostaglandins is minimized, meaning that the swelling and pain is eased.

Precautions

Before taking aceclofenac, it is essential to tell the doctor if one has ever had an allergic reaction to any other NSAID, for instance, diclofenac, aspirin, indomethacin, and naproxen; whether one has allergic disorders such as asthma. It is important to alert the doctor if an individual has a heart condition or problem with circulation or blood vessels. Moreover, inform the physician if one has connective tissue disorder, for instance, lupus erythematosus. One should not take the drug if he/she has high blood pressure or has blood-clotting problems.

Description

Aceclofenac is a nonsteroidal antiinflammatory agent with analgesic and antipyretic properties. It is reported to be useful in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with minor surgical procedures. Compared to ketoprofen in the treatment of rheumatoid arthritis, aceclofenac is substantially faster acting.

Chemical Properties

White Crystalline Solid

Originator

Prodes (Prodesfarma) (Spain)

Uses

Labeled Aceclofenac, intended for use as an internal standard for the quantification of Aceclofenac by GC- or LC-mass spectrometry.

Uses

Aceclofenac is a non-steroidal, anti-inflammatory drug (NSAID) with potent inhibitory activity in several models of inflammation. It is used for the treatment of osteoarthritis and rheumatoid arthritis. It is a Biopharmaceutics classification system class II (BCS class I) drug which has an intermediate half-life of 3-4h and undergoes substantial first pass metabolism. aceclofenac is available either in oral form (tablet) or in topical form (gel).

Definition

ChEBI: Aceclofenac is a monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is a monocarboxylic acid, a carboxylic ester, a secondary amino compound, an amino acid and a dichlorobenzene. It derives from a diclofenac.

brand name

Airtal; Gerbin

Therapeutic Function

Analgesic, Antiinflammatory

Biochem/physiol Actions

Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.

Clinical Use

NSAID and analgesic

Drug interactions

Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists: antagonism of hypotensive effect; increased risk of nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more NSAIDs, including aspirin (increased side effects); avoid with ketorolac (increased risk of side effects and haemorrhage).
Antibacterials: possible increased risk of convulsions with quinolones.
Anticoagulants: effects of coumarins and phenindione enhanced; possibly increased risk of bleeding with heparins, dabigatran and edoxaban - avoid long term use with edoxaban.
Antidepressants: increased risk of bleeding with SSRIs and venlaflaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin concentration.
Antivirals: increased risk of haematological toxicity with zidovudine; concentration possibly increased by ritonavir.
Ciclosporin: may potentiate nephrotoxicity
Cytotoxics: reduced excretion of methotrexate; increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity; antagonism of diuretic effect, hyperkalaemia with potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity.

Metabolism

About two-thirds of a dose is excreted in the urine, mainly as hydroxymetabolites, the principal one being 4-hydroxyaceclofenac. A small amount is converted to diclofenac.

Aceclofenac Preparation Products And Raw materials

Raw materials

Preparation Products

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Aceclofenac Suppliers

Hubei Zhonglong Kangsheng fine chemical Co.,Ltd
Tel
027-027-82752821 18186694582
Fax
027-82752821
Email
323495346@qq.com
Country
China
ProdList
2025
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2341
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9555
Advantage
66
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10194
Advantage
62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
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View Lastest Price from Aceclofenac manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Aceclofenac 89796-99-6
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-29
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Aceclofenac 89796-99-6
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99.0%~101.0%; BP2018
Supply Ability
15tons/month
Release date
2021-06-05
Hebei Mojin Biotechnology Co., Ltd
Product
Aceclofenac 89796-99-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-13

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