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Articaine

Product Name
Articaine
CAS No.
23964-58-1
Chemical Name
Articaine
Synonyms
40045;ARTICAINE;Articaina;Articainum;Carticaine;ARTICAINE HCL;Unii-D3sq406G9x;Articaine (40 mg);Articaine 23964-58-1;Articaine HCl (base)
CBNumber
CB9115297
Molecular Formula
C13H20N2O3S
Formula Weight
284.37
MOL File
23964-58-1.mol
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Articaine Property

Melting point:
175-176 °C
Boiling point:
bp0.3 162-167°
Density 
1.178±0.06 g/cm3(Predicted)
pka
13.46±0.70(Predicted)
CAS DataBase Reference
23964-58-1(CAS DataBase Reference)
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Safety

HS Code 
2934990002
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Hazard and Precautionary Statements (GHS)

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Articaine Chemical Properties,Usage,Production

Description

Articaine [4-methyl-3-(2-propylaminopropionamido) thiophene-2-carboxylic acid methyl ester hydrochloride] has been widely used in dentistry since its approval by the U.S. FDA in the year 2000 because of its quick onset and short duration of action. The structure of articaine differs from those of all other amino amide-type local anesthetics in that it contains a thiophene ring instead of a benzene ring and a carbomethoxy group. This renders the molecule more lipophilic and, thus, easier to cross any lipoidal membranes.
Its local anesthetic potency is approximately 1.5-fold that of lidocaine, even though it has similar pKa (7.8) and plasma protein binding (76%) properties. Articaine also is metabolized primarily by plasma cholinesterases because of the presence of an ester group and, therefore, has a much shorter duration of action than lidocaine (i.e., only approximately one-fourth that of lidocaine). Articaine undergoes rapid hydrolysis of the carbomethoxy group to give articainic acid, which is eliminated either unchanged (75%) or as its glucuronides (25%). Compared with to other shortacting, amino amide-type local anesthetics, such as mepivacaine, lidocaine, or prilocaine, articaine is said to be a much safer drug for regional anesthesia and is the drug of choice for dental procedures.

Originator

Ultracain,Hoechst,W. Germany,1976

Uses

Articaine is an amide based short-acting local anesthetic use for regional anaesthesia in day-case settings such arthroscopy, hand , food surgery and in dentistry.

Manufacturing Process

3-α-Chloropropionylamino-2-carbomethoxy-4-methylthiophene (prepared from 3-amino-2-carbomethoxy-4-methylthiophene and chloropropionyl chloride) was dissolved in toluene and n-propylamine added. The whole mixture was heated to boiling for 6 to 7 hours. After cooling, the propylamine hydrochloride that had formed was removed by washing with water, The toluene phase was dried with sodium sulfate, and then the solvent and excess propylamine were removed by distillation. The oily residue was taken up in ether. The hydrochloride of 3-n-propylamino-α-propionylamino-2- carbomethoxy-4-methylthiophene was obtained by introducing hydrogen chloride gas or by means of methanolic hydrogen chloride. The base boils at 162°C to 167°C under 0.3 mm of mercury pressure and the hydrochloride melts at 177°C to 178°C.

Therapeutic Function

Local anesthetic

Contact allergens

This local amide-type anesthetic is seldom reported as allergenic even in patients sensitized to other amidetype molecules like lidocaine, prilocaine, mepivacaine, or bupivacaine.

Articaine Preparation Products And Raw materials

Raw materials

Preparation Products

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Articaine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19999
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9844
Advantage
79
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
Vientiane Tianjin Hengyuan Technology Co., Ltd.
Tel
15722085254
Fax
022-26358246
Email
phytochemical@126.com
Country
China
ProdList
813
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com
Country
China
ProdList
26607
Advantage
56
Finetech Industry Limited
Tel
027-87465837-
Fax
027-8777-2287
Email
sales@finetechnology-ind.com;
Country
China
ProdList
9375
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432-
Fax
0571-87396431
Email
sales@jhechem.com;
Country
China
ProdList
13965
Advantage
53
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Please Email
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9550
Advantage
50
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View Lastest Price from Articaine manufacturers

Wuhan Aoliqisi New Material Technology Co., Ltd.
Product
Propitocaine HCl 23964-58-1
Price
US $1.00/g
Min. Order
1000g
Purity
99%
Supply Ability
20ton/month
Release date
2021-07-08
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Articaine HCL
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2021-02-20
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Articaine
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2021-01-16

23964-58-1, ArticaineRelated Search:


  • ARTICAINE
  • ARTICAINE HCL
  • methyl 4-methyl-3-(2-propylaminopropanoylamino)thiophene-2-carboxylate
  • 4-Methyl-3-[2-[propylamino] propionamido]-2-thiophenecarboxylic acid, methyl ester
  • Carticaine
  • 40045
  • 4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester
  • 4-Methyl-3-[1-oxo-2-(propylamino)propylamino]-2-thiophenecarboxylic acid methyl ester
  • Articaina
  • Articaina [inn-spanish]
  • Articainum
  • Articainum [inn-latin]
  • Methyl (4-methyl-3-(2-(propylamino)propionamido)-2-thiophencarboxylat)
  • Unii-D3sq406G9x
  • Articaine (40 mg)
  • 2-Thiophenecarboxylicacid, 4-Methyl-3-[[1-oxo-2-(propylaMino)propyl]aMino]-, Methyl ester
  • Aceclofenac EP IMpurity H
  • Articaine HCl (base)
  • articaine:methyl 4-methyl-3-(2-propylaminopropanoylamino)thiophene-2-carboxylate
  • Articaine 23964-58-1
  • Articaine (free base)
  • 23964-58-1
  • 23964-97-0
  • C13H21ClN2O3S
  • C13H20N2O3S