METHYL 4-AMINOSALICYLATE
- Product Name
- METHYL 4-AMINOSALICYLATE
- CAS No.
- 4136-97-4
- Chemical Name
- METHYL 4-AMINOSALICYLATE
- Synonyms
- pasmethylester;4-AMINOSALICYLATE;THYL 4-AMINOSALICYLATE;methylp-aminosalicylate;Methdilazine Impurity 1;METHYL 4-AMINOSALICYLATE;P-AMINO METHYL SALICYLATE;4-AMINOSALICYLICMETHYLESTER;4-AMINOSALICYLIC ACID ESTER;Methyl4-aminosalicylate,97%
- CBNumber
- CB2348357
- Molecular Formula
- C8H9NO3
- Formula Weight
- 167.16
- MOL File
- 4136-97-4.mol
METHYL 4-AMINOSALICYLATE Property
- Melting point:
- 120-123°C
- Boiling point:
- 120 °C
- Density
- 1.305±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 9.81±0.10(Predicted)
- form
- Powder
- color
- White to Pale Beige
- Water Solubility
- Slightly soluble in water.
- λmax
- 254nm(lit.)
- CAS DataBase Reference
- 4136-97-4(CAS DataBase Reference)
Safety
- RTECS
- VO1683000
- HazardClass
- IRRITANT
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- PHR2508
- Product name
- Methyl 4-Amino-2-hydroxybenzoate
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 100 mg
- Price
- $627
- Updated
- 2025/07/31
- Product number
- M2699
- Product name
- Methyl 4-Aminosalicylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $73
- Updated
- 2025/07/31
- Product number
- 455441
- Product name
- Methyl 4-aminosalicylate
- Packaging
- 500mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- M328665
- Product name
- Methyl 4-Aminosalicylate
- Packaging
- 2.5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR8934
- Product name
- Methyl4-amino-2-hydroxybenzoate
- Purity
- 97%
- Packaging
- 25g
- Price
- $73
- Updated
- 2021/12/16
METHYL 4-AMINOSALICYLATE Chemical Properties,Usage,Production
Uses
Methyl 4-aminosalicylate is used as pharmaceutical intermediate.
Definition
ChEBI: P-Aminosalicylic acid methyl ester is an aromatic amine.
Synthesis
13684-28-1
4136-97-4
Step 2: Preparation of methyl 4-amino-2-hydroxybenzoate In a 500 mL Parr reactor, methyl 2-hydroxy-4-nitrobenzoate (1.3 g, 6.59 mmol) was mixed with a suspension formed by 10% Pd/C catalyst (100 mg) in methanol (40 mL). The reaction mixture was shaken for 1 h under hydrogen atmosphere (30 psi). Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. Methyl 4-amino-2-hydroxybenzoate was obtained as a yellow solid (1.08 g, 6.46 mmol, 98% yield). The product was analyzed by UPLC-MS showing 100% purity and the mass spectrum (MS/ESI+) showed a molecular ion peak [MH]+ of 167.9.
References
[1] ACS Catalysis, 2014, vol. 4, # 6, p. 1777 - 1782
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 20, p. 3597 - 3600
[3] Patent: US2014/155391, 2014, A1. Location in patent: Paragraph 0432; 0434
[4] Journal of the Chemical Society, 1949, p. 1498,1502
[5] Proceedings - Indian Academy of Sciences, Section A, 1950, vol. 32, p. 357,362
METHYL 4-AMINOSALICYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 4-AMINOSALICYLATE manufacturers
- Product
- Methyl 4-amino-2-hydroxybenzenecarboxylate 4136-97-4
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1000kg
- Release date
- 2021-09-14
- Product
- METHYL 4-AMINOSALICYLATE 4136-97-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-04
- Product
- METHYL 4-AMINOSALICYLATE 4136-97-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-06-06