Methyl 4-amino-3-methoxybenzoate

Product Name: Methyl 4-amino-3-methoxybenzoate
CAS No.: 41608-64-4
Chemical Name: Methyl 4-amino-3-methoxybenzoate
Synonyms: 4-amino-3-methoxybenzoate;METHYL 3-METHOXY-4-AMINOBENZOATE;METHYL 4-AMINO-3-METHOXYBENZOATE;MEHYL-3-METHOXY-4-AMINO BENZOATE;Methyl4-amino-3-methoxybenzoate98%;Methyl 4-amino-3-methoxybenzoate 98%;4-AMINO-3-METHOXYBENZOIC ACID ETHYL ESTER;3-METHOXY-4-AMINOBENZOIC ACID METHYL ESTER;METHYL 4-AMINO-3-METHOXYBENZENECARBOXYLATE;4-Amino-3-methoxy benzoic acid methyl ester
CBNumber: CB6179106
Molecular Formula: C9H11NO3
Formula Weight: 181.19
MOL File: 41608-64-4.mol

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Methyl 4-amino-3-methoxybenzoate Property

Melting point:: 128-131°
Boiling point:: 332.0±22.0 °C(Predicted)
Density: 1.179±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: solid
pka: 2.41±0.10(Predicted)
color: Red
InChI: InChI=1S/C9H11NO3/c1-12-8-5-6(9(11)13-2)3-4-7(8)10/h3-5H,10H2,1-2H3
InChIKey: DJLFOMMCQBAMAA-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(N)C(OC)=C1
CAS DataBase Reference: 41608-64-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3716
Product name: Methyl 4-Amino-3-methoxybenzoate
Purity: min. 98.0 %
Packaging: 5G
Price: $101
Updated: 2025/07/31

TCI Chemical

Product number: A3716
Product name: Methyl 4-Amino-3-methoxybenzoate
Purity: min. 98.0 %
Packaging: 25G
Price: $303
Updated: 2025/07/31

TRC

Product number: M328663
Product name: Methyl4-amino-3-methoxybenzoate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M328663
Product name: Methyl4-amino-3-methoxybenzoate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA70673
Product name: 4-Amino-3-methoxybenzoic acid methyl ester
Packaging: 50g
Price: $82.5
Updated: 2021/12/16

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Methyl 4-amino-3-methoxybenzoate Chemical Properties,Usage,Production

Uses

Methyl 4-amino-3-methoxybenzoate is mainly used in the preparation of other organic heterocyclic compounds or pharmaceutical small molecule inhibitors.

Synthesis

5081-37-8

41608-64-4

The general procedure for the synthesis of methyl 4-amino-3-methoxybenzoate from methyl 3-methoxy-4-nitrobenzoate was as follows: methyl 3-methoxybenzoate (83.0 g, 500 mmol) was added drop-wise to a mixture of acids consisting of HNO3 (65% by weight, 40 ml) and H2SO4 (70% by weight, 200 ml) at 0 °C. The reaction mixture was stirred overnight and poured into ice water. The mixture was filtered and the solid filter cake was washed with water (3 x 300 ml) to give 84.4 g of methyl 4-nitro-3-methoxybenzoate as a yellow solid in 80% yield. Next, an ethanol (1500 ml) solution of methyl 4-nitro-3-methoxybenzoate (84.4 g, 400 mmol) was stirred with Pd/C (10% Pd, 5.35 g) catalyst for 5 h under H2 atmosphere. After completion of the reaction, the catalyst was removed by Celite? filtration. The solvent was evaporated in vacuum to give an off-white solid. Finally, the off-white solid was recrystallized from methanol to give methyl 4-amino-3-methoxybenzoate (70.95 g, 392 mmol) in 98% yield.

References

[1] Patent: WO2010/56722, 2010, A1. Location in patent: Page/Page column 360
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 19, p. 7035 - 7047
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 5, p. 1843 - 1852
[4] Australian Journal of Chemistry, 1988, vol. 41, # 7, p. 1087 - 1097
[5] Patent: CN107698598, 2018, A. Location in patent: Paragraph 0065-0068

Methyl 4-amino-3-methoxybenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-amino-3-methoxybenzoate Suppliers

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View Lastest Price from Methyl 4-amino-3-methoxybenzoate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Methyl 4-amino-3-methoxybenzoate 41608-64-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-05

Henan Aochuang Chemical Co.,Ltd.

Product: Methyl 4-amino-3-methoxybenzoate 41608-64-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

LY Global chemicals co.,ltd .

Product: Methyl 4-amino-3-methoxybenzoate 41608-64-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2023-03-19

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41608-64-4

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