Methyl 4-amino-3-methoxybenzoate
- Product Name
- Methyl 4-amino-3-methoxybenzoate
- CAS No.
- 41608-64-4
- Chemical Name
- Methyl 4-amino-3-methoxybenzoate
- Synonyms
- 4-amino-3-methoxybenzoate;METHYL 3-METHOXY-4-AMINOBENZOATE;METHYL 4-AMINO-3-METHOXYBENZOATE;MEHYL-3-METHOXY-4-AMINO BENZOATE;Methyl4-amino-3-methoxybenzoate98%;Methyl 4-amino-3-methoxybenzoate 98%;4-AMINO-3-METHOXYBENZOIC ACID ETHYL ESTER;3-METHOXY-4-AMINOBENZOIC ACID METHYL ESTER;METHYL 4-AMINO-3-METHOXYBENZENECARBOXYLATE;4-Amino-3-methoxy benzoic acid methyl ester
- CBNumber
- CB6179106
- Molecular Formula
- C9H11NO3
- Formula Weight
- 181.19
- MOL File
- 41608-64-4.mol
Methyl 4-amino-3-methoxybenzoate Property
- Melting point:
- 128-131°
- Boiling point:
- 332.0±22.0 °C(Predicted)
- Density
- 1.179±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- solid
- pka
- 2.41±0.10(Predicted)
- color
- Red
- InChI
- InChI=1S/C9H11NO3/c1-12-8-5-6(9(11)13-2)3-4-7(8)10/h3-5H,10H2,1-2H3
- InChIKey
- DJLFOMMCQBAMAA-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(N)C(OC)=C1
- CAS DataBase Reference
- 41608-64-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A3716
- Product name
- Methyl 4-Amino-3-methoxybenzoate
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $101
- Updated
- 2025/07/31
- Product number
- A3716
- Product name
- Methyl 4-Amino-3-methoxybenzoate
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $303
- Updated
- 2025/07/31
- Product number
- M328663
- Product name
- Methyl4-amino-3-methoxybenzoate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M328663
- Product name
- Methyl4-amino-3-methoxybenzoate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FA70673
- Product name
- 4-Amino-3-methoxybenzoic acid methyl ester
- Packaging
- 50g
- Price
- $82.5
- Updated
- 2021/12/16
Methyl 4-amino-3-methoxybenzoate Chemical Properties,Usage,Production
Uses
Methyl 4-amino-3-methoxybenzoate is mainly used in the preparation of other organic heterocyclic compounds or pharmaceutical small molecule inhibitors.
Synthesis
5081-37-8
41608-64-4
The general procedure for the synthesis of methyl 4-amino-3-methoxybenzoate from methyl 3-methoxy-4-nitrobenzoate was as follows: methyl 3-methoxybenzoate (83.0 g, 500 mmol) was added drop-wise to a mixture of acids consisting of HNO3 (65% by weight, 40 ml) and H2SO4 (70% by weight, 200 ml) at 0 °C. The reaction mixture was stirred overnight and poured into ice water. The mixture was filtered and the solid filter cake was washed with water (3 x 300 ml) to give 84.4 g of methyl 4-nitro-3-methoxybenzoate as a yellow solid in 80% yield. Next, an ethanol (1500 ml) solution of methyl 4-nitro-3-methoxybenzoate (84.4 g, 400 mmol) was stirred with Pd/C (10% Pd, 5.35 g) catalyst for 5 h under H2 atmosphere. After completion of the reaction, the catalyst was removed by Celite? filtration. The solvent was evaporated in vacuum to give an off-white solid. Finally, the off-white solid was recrystallized from methanol to give methyl 4-amino-3-methoxybenzoate (70.95 g, 392 mmol) in 98% yield.
References
[1] Patent: WO2010/56722, 2010, A1. Location in patent: Page/Page column 360
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 19, p. 7035 - 7047
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 5, p. 1843 - 1852
[4] Australian Journal of Chemistry, 1988, vol. 41, # 7, p. 1087 - 1097
[5] Patent: CN107698598, 2018, A. Location in patent: Paragraph 0065-0068
Methyl 4-amino-3-methoxybenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 4-amino-3-methoxybenzoate Suppliers
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- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
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View Lastest Price from Methyl 4-amino-3-methoxybenzoate manufacturers
- Product
- Methyl 4-amino-3-methoxybenzoate 41608-64-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-05
- Product
- Methyl 4-amino-3-methoxybenzoate 41608-64-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- Methyl 4-amino-3-methoxybenzoate 41608-64-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2023-03-19